THERE IS a strong relation and bidirectional relation between oral health state and systemic health .chronic microbial diseases like periodontitis contrbute into bacteremia which play a major role in propagate an inflamatory casacade of event that is finalise by resultant systemic diseases. Most systemic diseases have oral manifestation and viceversa.
oral health state is a gate for systemic health indicator. there is a strong relation between oral health and systemic health. the pathogenesis is due to sub clinical response from periodontal diseases propagate inflammatory event progress to produce systemic diseases.
Presentation made by Patricial Bonwell on the 29th of August, 2014 at the live webinar hosted by AlzPossible: http://alzpossible.org/webinars-2/hands-on/oral-health-and-dementia/
oral health state is a gate for systemic health indicator. there is a strong relation between oral health and systemic health. the pathogenesis is due to sub clinical response from periodontal diseases propagate inflammatory event progress to produce systemic diseases.
Presentation made by Patricial Bonwell on the 29th of August, 2014 at the live webinar hosted by AlzPossible: http://alzpossible.org/webinars-2/hands-on/oral-health-and-dementia/
Fortunately we are not alone and we provide residence to numerous microbial
communities comprising of bacterial species. The human body is made up of 10 14 cells of which
only 10% are mammalian and the remainder is contributed by the microorganisms that make up
the resident micro flora of the host. Normal microbial flora is a term that denotes the population
of microorganism that inhabit the skin and mucous membranes of healthy normal persons.
Numerous bacterial species colonize the mouth, upper airways, skin, vagina and intestinal tract
of humans where each one have a unique site specific fingerprint made of distinct microbe with
high level of diversity which is still unexplained.These microorganism are inhabit in the oral
cavity and their unavoidable interrelationships are essential component in maintaining
homeostasis between health and disease moreover the skin and mucous membrane always harbor
variety of organisms and they can be further categorized into two groups. One is the resident
flora which consists of relatively fixed type of microorganisms regularly found in given area at a
given age, and promptly gathers and re-establishes itself even if it is disturbed. The other one is
the transient flora, consist of non-pathogenic or potentially pathogenic microorganisms that
inhabit skin or mucous membrane for hours, days or week and it is derived from the environment
that does not produce disease and does not have the capacity to reestablish permanently on the
surface. However if the resident flora is disturbed, transient microorganisms may get colonized,
proliferate and produce disease. This indigenous microbiota plays an important role in health and
diseases of humans and contributing to the development of the immune system and provides
resistance to colonization by pathogenic microorganisms. Thereby the presentation is intended to
review on the importance and thrust areas of oral microbiome in health and disease.
The primary goal of the present book is to produce a comprehensive text that fully integrates the latest concepts and techniques in management of odontogenic infections. The main aim is to provide the readers with an update information regarding pathophysiology, clinical and radiographic presentation, microbiology, diagnosis, management, and complications of odontogenic infections. Accordingly, the text has been divided into six chapters. Chapter one is concerned with oral microbiology and immunology. Chapter two is dealing with the pathophysiology of odontogenic infections. In chapter three, management of odontogenic infections is presented. In chapter four, antibiotic therapy of odontogenic infections is given. Chapter five deals with life-threatening complications. In chapter six osteomyelitis of the jaws is discussed.
PERIODONTAL MEDICINE 1.pptx DIABETES DIABENitika588942
The term periodontal medicine, as first suggested by Offenbacher, that defines a rapidly emerging branch of periodontology focusing on the wealth of new data establishing a strong relationship between periodontal health or disease and systemic health or disease.
This means a two-way relationship in which periodontal disease in an individual may be a powerful influence on an individual’s systemic health or disease as well as the more customarily understood role that systemic disease may have in influencing an individual’s periodontal health or disease.It would be new diagnostic and treatment strategies that recognize the relationship between periodontal disease and systemic disease.
William Hunter, attesting to the influence of oral sepsis on systemic health and disease.
Recently scientists and clinicians have begun to provide an increasing body of scientific evidence suggesting that moderate untreated periodontitis may affect an individual systemically, and may contribute to cardiovascular disease, diabetes and pre-term low birth weight.This is important new information indeed. It appears that not just teeth are at stake in maintaining good oral health.
Rather, oral health is an important component of general health, and individuals with periodontitis may be at risk for other diseases as well.
Evidence has also shed light on the converse side of the relationship between systemic health and oral health: the potential effects of inflammatory periodontal diseases on a wide range of organ systems.Pathogenesis of periodontitis has changed remarkably over last 30 years.
The non-specific accumulation of bacterial plaque was once thought to be the cause of periodontal destruction, but it is now recognized that periodontitis is an infectious disease associated with a small number of predominantly gram-negative microorganisms that exist in a subgingival biofilm.
Furthermore, the importance of the host in disease initiation and progression is clearly recognized.
Although pathogenic bacteria are necessary for periodontal disease, they are not sufficient alone to cause the disease.
A susceptible host is also imperative. In a host who has relatively low susceptibility to disease, bacterial pathogens may have no clinical effect.
This may be due to a particularly effective host immunoinflammatory response that eliminates pathogenic organisms while minimizing destruction of native tissues.
Conversely, in a host with relatively high disease susceptibility, marked destruction of periodontal tissues may result.Acc. To William Hunter in 1900,
Oral microorganism- responsible for systemic conditions
Restoration instead of extraction, trapping of infectious agents
Gingivitis & periodontitis- foci of infection .Acc. To William Hunter in 1900,
Oral microorganism- responsible for systemic conditions
Restoration instead of extraction, trapping of infectious agents
Gingivitis & periodontitis- foci of infection
Acc. To William Hunter in 1900,
Oral microorganism
Essentials of Periodontal Medicine in Preventive MedicineMinkle Gulati
Influence of systemic disorders on periodontal diseases is well established. However, of growing interest is the effect of periodontal diseases on numerous systemic diseases or conditions like cardiovascular disease, cerebrovascular disease, diabetes, pre‑term low birth weight babies, preeclampsia, respiratory infections and others including osteoporosis, cancer, rheumatoid arthritis, erectile dysfunction, Alzheimer’s disease, gastrointestinal
disease, prostatitis, renal diseases, which has also been scientifically validated. This side of the oral‑systemic link has been termed Periodontal Medicine and is potentially of great public health significance, as periodontal disease is largely preventable and in many instances readily treatable, hence, providing many new opportunities for preventing and improving prognosis of several systemic pathologic conditions. This review article highlights the importance of prevention and treatment of periodontal diseases as an essential part of preventive medicine to circumvent its deleterious effects on general health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Fortunately we are not alone and we provide residence to numerous microbial
communities comprising of bacterial species. The human body is made up of 10 14 cells of which
only 10% are mammalian and the remainder is contributed by the microorganisms that make up
the resident micro flora of the host. Normal microbial flora is a term that denotes the population
of microorganism that inhabit the skin and mucous membranes of healthy normal persons.
Numerous bacterial species colonize the mouth, upper airways, skin, vagina and intestinal tract
of humans where each one have a unique site specific fingerprint made of distinct microbe with
high level of diversity which is still unexplained.These microorganism are inhabit in the oral
cavity and their unavoidable interrelationships are essential component in maintaining
homeostasis between health and disease moreover the skin and mucous membrane always harbor
variety of organisms and they can be further categorized into two groups. One is the resident
flora which consists of relatively fixed type of microorganisms regularly found in given area at a
given age, and promptly gathers and re-establishes itself even if it is disturbed. The other one is
the transient flora, consist of non-pathogenic or potentially pathogenic microorganisms that
inhabit skin or mucous membrane for hours, days or week and it is derived from the environment
that does not produce disease and does not have the capacity to reestablish permanently on the
surface. However if the resident flora is disturbed, transient microorganisms may get colonized,
proliferate and produce disease. This indigenous microbiota plays an important role in health and
diseases of humans and contributing to the development of the immune system and provides
resistance to colonization by pathogenic microorganisms. Thereby the presentation is intended to
review on the importance and thrust areas of oral microbiome in health and disease.
The primary goal of the present book is to produce a comprehensive text that fully integrates the latest concepts and techniques in management of odontogenic infections. The main aim is to provide the readers with an update information regarding pathophysiology, clinical and radiographic presentation, microbiology, diagnosis, management, and complications of odontogenic infections. Accordingly, the text has been divided into six chapters. Chapter one is concerned with oral microbiology and immunology. Chapter two is dealing with the pathophysiology of odontogenic infections. In chapter three, management of odontogenic infections is presented. In chapter four, antibiotic therapy of odontogenic infections is given. Chapter five deals with life-threatening complications. In chapter six osteomyelitis of the jaws is discussed.
PERIODONTAL MEDICINE 1.pptx DIABETES DIABENitika588942
The term periodontal medicine, as first suggested by Offenbacher, that defines a rapidly emerging branch of periodontology focusing on the wealth of new data establishing a strong relationship between periodontal health or disease and systemic health or disease.
This means a two-way relationship in which periodontal disease in an individual may be a powerful influence on an individual’s systemic health or disease as well as the more customarily understood role that systemic disease may have in influencing an individual’s periodontal health or disease.It would be new diagnostic and treatment strategies that recognize the relationship between periodontal disease and systemic disease.
William Hunter, attesting to the influence of oral sepsis on systemic health and disease.
Recently scientists and clinicians have begun to provide an increasing body of scientific evidence suggesting that moderate untreated periodontitis may affect an individual systemically, and may contribute to cardiovascular disease, diabetes and pre-term low birth weight.This is important new information indeed. It appears that not just teeth are at stake in maintaining good oral health.
Rather, oral health is an important component of general health, and individuals with periodontitis may be at risk for other diseases as well.
Evidence has also shed light on the converse side of the relationship between systemic health and oral health: the potential effects of inflammatory periodontal diseases on a wide range of organ systems.Pathogenesis of periodontitis has changed remarkably over last 30 years.
The non-specific accumulation of bacterial plaque was once thought to be the cause of periodontal destruction, but it is now recognized that periodontitis is an infectious disease associated with a small number of predominantly gram-negative microorganisms that exist in a subgingival biofilm.
Furthermore, the importance of the host in disease initiation and progression is clearly recognized.
Although pathogenic bacteria are necessary for periodontal disease, they are not sufficient alone to cause the disease.
A susceptible host is also imperative. In a host who has relatively low susceptibility to disease, bacterial pathogens may have no clinical effect.
This may be due to a particularly effective host immunoinflammatory response that eliminates pathogenic organisms while minimizing destruction of native tissues.
Conversely, in a host with relatively high disease susceptibility, marked destruction of periodontal tissues may result.Acc. To William Hunter in 1900,
Oral microorganism- responsible for systemic conditions
Restoration instead of extraction, trapping of infectious agents
Gingivitis & periodontitis- foci of infection .Acc. To William Hunter in 1900,
Oral microorganism- responsible for systemic conditions
Restoration instead of extraction, trapping of infectious agents
Gingivitis & periodontitis- foci of infection
Acc. To William Hunter in 1900,
Oral microorganism
Essentials of Periodontal Medicine in Preventive MedicineMinkle Gulati
Influence of systemic disorders on periodontal diseases is well established. However, of growing interest is the effect of periodontal diseases on numerous systemic diseases or conditions like cardiovascular disease, cerebrovascular disease, diabetes, pre‑term low birth weight babies, preeclampsia, respiratory infections and others including osteoporosis, cancer, rheumatoid arthritis, erectile dysfunction, Alzheimer’s disease, gastrointestinal
disease, prostatitis, renal diseases, which has also been scientifically validated. This side of the oral‑systemic link has been termed Periodontal Medicine and is potentially of great public health significance, as periodontal disease is largely preventable and in many instances readily treatable, hence, providing many new opportunities for preventing and improving prognosis of several systemic pathologic conditions. This review article highlights the importance of prevention and treatment of periodontal diseases as an essential part of preventive medicine to circumvent its deleterious effects on general health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Oral health is a gate for systemic health [Autosaved].pptx
1. Oral Health as a public health
indicator
Marina Sameh
Yassmen Hesham
Zead Hossam
Muhanad Ehab Rady
Under Supervision
Dr. Shimaa Hussein
2. Mouth is a mirror of the internal
secrets of systemic health
Sample Footer Text
2
3. Oral Health An integral part of general
health and well-being
1/2/2024
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3
4. Oral cavity
Is intersection of medicine and dentistry.
Is a window into the general health of a
patient.
1/2/2024
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4
5. Importance of Oral Health
oral health and general health should not
be interpreted as a separate entities.
Oral health means more than a healthy
teeth.
No one can be healthy without oral health
1/2/2024
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5
6. What happens if oral health problems
are ignored?
pain and suffering
Devastating health complications , with
financial and social costs
Diminish the quality of life and burdens
society
1/2/2024
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6
7. Oral Diseases
is a “Silent epidemic” condition .
Affect all populations:
Children
Elderly
No gender difference (male like female)
1/2/2024
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7
8. Oral health means much more
than healthy teeth
It means free from :
chronic oral-facial pain conditions
oral and pharyngeal diseases
oral soft tissue lesions
birth defects such as cleft lip and palate.oral, dental, and
craniofacial tissues (craniofacial complex)
1/2/2024
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8
9. The mouth is a mirror of
systemic health
A thorough oral examination can detect:
signs of nutritional deficiencies
microbial infections
immune disorders
injuries
some cancer
1/2/2024
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9
10. What is the relationship between oral health
and general health and well-being?
1/2/2024
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10
11. What is the relationship between oral health
and general health and well-being?
Many systemic diseases have initial signs of
oral manifestations.
Oral cavity is a portal of entry of microbial
disease infections that affect general health
state.
Oral cavity adversely affected by
pharmaceuticals therapies used for treating
systemic conditions. 1/2/2024
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11
12. Oral and craniofacial diseases contribute to :
compromised ability to
bite, chew and swallow
foods.
limitations in food
selection.
poor nutrition.
1/2/2024
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12
13. Oral manifestations of systemic disease
Periodontal diseases
ORAL ULCERS
Xerostomia
Root caries
Allergy and Mucosal changes due to drug therapy
Benign soft tissue lesions and keratotic lesions, chiefly local
Retarded eruption
Psychic disorders
1/2/2024
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13
14. Separate Medical/Dental Education Systems
Medical Education System
does not help put oral health
on phyisician’s Radars!
1/2/2024
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14
15. Mechanisms that mediate the connection
between oral and systemic health
Gene polymorphisms
Environmental factors (stress, habits—such as
smoking and high‐fat diets/consumption of highly
processed foods)
Medications
Microbial dysbiosis that altered host immune
response. 1/2/2024
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15
16. Microbial dysbiosis
More than 400 species
of bacteria create an
exquisite microbial
ecological system in
the form of a biofilm
1/2/2024
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16
17. Oral infections
17
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periodontal
diseases :
are the most
common chronic
microbial diseases
in the world.
18. Gingival and periodontal diseases
is the most widespread
chronic inflammatory
response to oral
microbes’
1/2/2024
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18
19. Role of Oral biofilm in systemic diseases
1/2/2024
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19
21. How Oral Microbes Cause Systemic
Disease?
Oral – infection – associated
bacteremias can contributes
to the risk of acute events.
1/2/2024
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21
22. The Emerging Connection between Oral
infection & Systemic diseases
1/2/2024
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22
24. Oral infections are associated with a number of
systemic diseases and disorders
Bidirection relation between periodontal
disease and :
Heart diseases
Diabetes mellitus
H,pylori
respiratory diseases
Preterm baby
other diseases in immunocompromised
patients especially those with cancer.
1/2/2024
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24
25. There is a strong association between
periodontitis and ……
1/2/2024
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25
26. The effects of oral Disease
on Systemic Disease
• The periodontium serve as a
reservoir of bacteria, bacterial
products, inflammation and
immune mediators.
• These factors can interact with
other organ systems remote from
the oral cavity.
1/2/2024
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26
44. Conclusions
44
1/2/2024
One should never underestimate oral
disorders as always curable.
People should take utmost care of the
oral condition seriously to prevent
significant complications.
Dental health should never be considered
a distinct, remote, and lower significant
part from general health
Oral health affects overall health
45. References
Makkar, H.; Reynolds, M.A.; Wadhawan, A.; Dagdag, A.;
Merchant, A.T.; Postolache, T.T. Periodontal, metabolic, and
cardiovascular disease: Exploring the role of inflammation and
mental health. Pteridines 2018, 29, 124–163
FDI World Dental Federation. Global periodontal health. Int.
Dent. J. 2019.
Botelho, J., Mascarenhas, P., Viana, J. et al. An umbrella review
of the evidence linking oral health and systemic
noncommunicable diseases. Nat Commun (2022); 13, 7614.
1/2/2024
Sample Footer Text
45