Dr. Tana Joseph (Founder of AstroComms and South African Astronomer) slide presentation on Career opportunities that young Africans can discover in Science at large.
This was in commemoration of the Global Astronomy Month, 2020 on the 25th of April 2020.
#STEM #Astronomy #science #GAM2020 #technology #scicomm
Integrating Science, Bridging Africa and Inspiring the future.STEMi Makers Africa
A Presentation done by Dr. Brenda Namumba (a Post-doctorate Fellow at the Rhodes University, South Africa and the First Zambian to hold a PhD in Astrophysics) discussing about Integrating Science, Bridging Africa and Inspiring the Future.
Find images online for your class papers and projects using the subscription database ARTstor. You can also try non-art databases like JSTOR and open access sources like Flickr. Created by J. Rinalducci.
Library resources and advanced search tips for your dissertation. Please also visit your library subject guide at http://libguides.ncl.ac.uk/hca/archclassics
Searching and Creating Open Educational ResourcesCEMCA
Searching and Creating Open Educational Resources: Presentation by Dr Sanjaya Mishra during the Workshop on OER for Librarians held at NIFT, New Delhi on 26 November 2014
Integrating Science, Bridging Africa and Inspiring the future.STEMi Makers Africa
A Presentation done by Dr. Brenda Namumba (a Post-doctorate Fellow at the Rhodes University, South Africa and the First Zambian to hold a PhD in Astrophysics) discussing about Integrating Science, Bridging Africa and Inspiring the Future.
Find images online for your class papers and projects using the subscription database ARTstor. You can also try non-art databases like JSTOR and open access sources like Flickr. Created by J. Rinalducci.
Library resources and advanced search tips for your dissertation. Please also visit your library subject guide at http://libguides.ncl.ac.uk/hca/archclassics
Searching and Creating Open Educational ResourcesCEMCA
Searching and Creating Open Educational Resources: Presentation by Dr Sanjaya Mishra during the Workshop on OER for Librarians held at NIFT, New Delhi on 26 November 2014
ILOA Galaxy Forum Southeast Asia 2014 - Steve Durst, ILOAILOAHawaii
ILOA is an interglobal enterprise incorporated in Hawaii as a 501(c)(3) non-profit to advance human knowledge of the Cosmos through observation from our Moon, and to participate in internationally cooperative lunar base build-out. The ILOA co-sponsors with its Space Age Publishing Company affiliate an international series of Galaxy Forums to advance 21st Century Education. Galaxy Forums, designed to provide greater global awareness, capabilities and action in Galaxy science, exploration and enterprise, are held in Hawaii, Silicon Valley, Canada, China, India, Japan, Europe, Africa, Brazil, Chile, Southeast Asia, Kansas and New York. Current plans are for expansion to Antarctica in 2014. For more information visit www.iloa.org.
Please join us as representatives from NASA, the Jet Propulsion Laboratory, Space Telescope Science Institute and the Astronomical Society of the Pacific share resources from their organizations that are easy to use and highly relevant for a library audience. These include everything from 3D printable moon-scapes, to how to get a NASA expert to your library! Get a head start on Summer Reading 2019 programming with this broad overview of NASA resources, and let us know after the webinar who you’d like to hear more from!
Out-of-this-World Activities - Part 1 WebinarNCIL - STAR_Net
Join STAR_Net and the Lunar and Planetary Institute to learn tips and tricks from LPI’s Explore program for engaging children, tweens, and families in space science with games, activities, and events.
ILOA Galaxy Forum Hawaii 2015 -- Steve Durst ILOAHawaii
International Lunar Observatory-1: Making Moon South Pole Astronomy and Communications a Reality – Steve Durst, Founding Director, International Lunar Observatory Association, Editor and Publisher of Space Age Publishing Co.
ILO-1 Moon South Pole: A new frontier as exciting and enriching as Humans on Mars or trillion dollar asteroids, and much closer in space and time.
Pursuing a series of Moon-based observatory missions to complement Earth-based and Space-based astronomy, ILOA seeks to advance Galaxy Imaging for 21st century astronomy education with its ILO-1 primary mission 2-meter radio antenna to Malapert Mt. 86°S 2.7°E near the Moon’s South Pole, with an ILO-X precursor mission aboard a GLXP lander, and with a Human Service Mission to the ILO-1 / robotic village new world frontier.
ILOA is also collaborating with the National Astronomical Observatories – Chinese Academy of Sciences (NAOC) Lunar Ultraviolet Telescope (LUT) at Mare Imbrium 44°N 20°W aboard the China Chang’e-3 Moon Lander, the first spacecraft to land on the Moon in almost 40 years and the only spacecraft operating on the lunar surface. Conducting science-driven and education-based Astronomy from the Moon via LUT is a foundational success of international cooperation on which the ILOA intends to build.
More than 40 years since the Far Ultraviolet Camera / Spectrograph operated on the Descartes Highlands by NASA Apollo 16 Commander and ILOA Board of Director Emeritus John Young in April 1972, ILOA is drawing together resources from across the planet to reclaim the cosmic revolution of Humanity as a Multi World Species.
The 7th Edition of ILOA’s stellar “Galaxy Map” is now being distributed to high school teachers and other educators around the world, designed for use in every class with maps of the world and Solar System
As libraries across the country prepare to implement space science-themed programs in summer 2019, the Space Science Institute and Lunar and Planetary Institute are partnering with state libraries to deliver training on NASA science learning experiences.
This effort is part of the SMD Science Activation program and the STAR Library Network-Collaborative Summer Library Program partnership.
ILOA Galaxy Forum Southeast Asia 2014 - Steve Durst, ILOAILOAHawaii
ILOA is an interglobal enterprise incorporated in Hawaii as a 501(c)(3) non-profit to advance human knowledge of the Cosmos through observation from our Moon, and to participate in internationally cooperative lunar base build-out. The ILOA co-sponsors with its Space Age Publishing Company affiliate an international series of Galaxy Forums to advance 21st Century Education. Galaxy Forums, designed to provide greater global awareness, capabilities and action in Galaxy science, exploration and enterprise, are held in Hawaii, Silicon Valley, Canada, China, India, Japan, Europe, Africa, Brazil, Chile, Southeast Asia, Kansas and New York. Current plans are for expansion to Antarctica in 2014. For more information visit www.iloa.org.
Please join us as representatives from NASA, the Jet Propulsion Laboratory, Space Telescope Science Institute and the Astronomical Society of the Pacific share resources from their organizations that are easy to use and highly relevant for a library audience. These include everything from 3D printable moon-scapes, to how to get a NASA expert to your library! Get a head start on Summer Reading 2019 programming with this broad overview of NASA resources, and let us know after the webinar who you’d like to hear more from!
Out-of-this-World Activities - Part 1 WebinarNCIL - STAR_Net
Join STAR_Net and the Lunar and Planetary Institute to learn tips and tricks from LPI’s Explore program for engaging children, tweens, and families in space science with games, activities, and events.
ILOA Galaxy Forum Hawaii 2015 -- Steve Durst ILOAHawaii
International Lunar Observatory-1: Making Moon South Pole Astronomy and Communications a Reality – Steve Durst, Founding Director, International Lunar Observatory Association, Editor and Publisher of Space Age Publishing Co.
ILO-1 Moon South Pole: A new frontier as exciting and enriching as Humans on Mars or trillion dollar asteroids, and much closer in space and time.
Pursuing a series of Moon-based observatory missions to complement Earth-based and Space-based astronomy, ILOA seeks to advance Galaxy Imaging for 21st century astronomy education with its ILO-1 primary mission 2-meter radio antenna to Malapert Mt. 86°S 2.7°E near the Moon’s South Pole, with an ILO-X precursor mission aboard a GLXP lander, and with a Human Service Mission to the ILO-1 / robotic village new world frontier.
ILOA is also collaborating with the National Astronomical Observatories – Chinese Academy of Sciences (NAOC) Lunar Ultraviolet Telescope (LUT) at Mare Imbrium 44°N 20°W aboard the China Chang’e-3 Moon Lander, the first spacecraft to land on the Moon in almost 40 years and the only spacecraft operating on the lunar surface. Conducting science-driven and education-based Astronomy from the Moon via LUT is a foundational success of international cooperation on which the ILOA intends to build.
More than 40 years since the Far Ultraviolet Camera / Spectrograph operated on the Descartes Highlands by NASA Apollo 16 Commander and ILOA Board of Director Emeritus John Young in April 1972, ILOA is drawing together resources from across the planet to reclaim the cosmic revolution of Humanity as a Multi World Species.
The 7th Edition of ILOA’s stellar “Galaxy Map” is now being distributed to high school teachers and other educators around the world, designed for use in every class with maps of the world and Solar System
As libraries across the country prepare to implement space science-themed programs in summer 2019, the Space Science Institute and Lunar and Planetary Institute are partnering with state libraries to deliver training on NASA science learning experiences.
This effort is part of the SMD Science Activation program and the STAR Library Network-Collaborative Summer Library Program partnership.
Similar to Opportunities for Africans to discover in Science. (20)
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
3. Studying the Universe and the objects inside it, like stars, galaxies,
planets, moons, comets, asteroids, clouds of gas. Using telescopes and
detectors that measure light, particles and waves and space debris
coming from these objects
Credit: Katz & Spiering (2011)
Credit: NASA Credit: Institute of Gravitational Research/ University of Glasgow.
Image: Christie's
4. About me
Decided to become an astronomer in the mid 90s
after seeing the incredible images
taken with the Hubble Space Telescope
5. About me
No roles models, no sci comm, few facilities and v. little public awareness
… But, We started building SALT in 2002
6. About me
By the time I finished my BSc in Physics in 2005, SALT was complete
7. About me
By the time I finished my PhD in 2013,
SA had been chosen as joint host of SKA and KAT-7 was complete
8. SKA in Africa
SKA SA Human Capital Development
(HCD)
9( 14( 28( 47( 54( 62(
88( 108( 86( 103( 122( 113( 109(
943(
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100(
200(
300(
400(
500(
600(
700(
800(
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2005( 2006( 2007( 2008( 2009( 2010( 2011( 2012( 2013( 2014( 2015( 2016( 2017( TOTAL(
Total(Number(of(Bursaries,(Fellowships(and(Grants(by(Year(
Credit: SKA
Credit: www.ska.ac.za – Rob Adam
9. How to get involved in astronomy in
Africa and around the world
• Attend webinars like this one
• Attend public events, e.g. NASA’s Observe the
Moon
https://moon.nasa.gov/observe-the-moon/annual-event/overview/
10. How to get involved in astronomy in
Africa and around the world
Citizen science!
Help astronomers (and other researchers) around
the world to analyse their data
A list of some citizen science projects can be found
on the SKA website
https://www.skatelescope.org/outreachandeducat
ion/outreach-resources/citizen-science/
11. “In the field of observations, chance favours the prepared
mind.”
- Louis Pasteur, referring to seemingly serendipitous discoveries
Wellcome Collection
12. Your studies
• Start prepping early
– Check deadlines, etc.
• Make contacts - social media is a good way to
get in touch with people
13. Funding opportunities
• Check local and international funding opps
• Best way is to follow funding bodies on social
media
• e.g. South Africa’s National Research Foundation
(NRF) regularly posts funding announcements
and calls for applications on Twitter
14. Be brave!
• Be brave and apply!
• Ask for advice and support from peers or more
senior students/colleagues/mentors
15. Be brave!
• Make use of training opps at your institution
– Speaker training
– Attend hacks to learn skills
– Writing courses
– Online courses
16. Non-academic opportunities
• Science communication (Scicomm)
– Maybe you have a gift for communicating with the
public
• Other careers, e.g. data science, teaching, etc.
– http://www.jobsforastronomers.com/careers
18. Some resources
• Resources for opportunities
• NRF https://www.nrf.ac.za/funding
• Office of Astronomy for Development http://www.astro4dev.org/aboutiauoad/oadteam/
• Organisation for Women in Science for the Developing World https://owsd.net/
• Royal Society
https://royalsociety.org/grants-schemes-awards/
• SKA
https://www.sarao.ac.za/students/funding/
• DARA
https://www.dara-project.org/, https://www.darabigdata.com/
• African Academy of Sciences
https://www.aasciences.africa/
• The World Academy of Sciences
https://twas.org/
Fulbright Programme
https://foreign.fulbrightonline.org/about/foreign-fulbright