OncoPrime - Drug screening platform using patient derived cells
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OncoPrime is Saarum Sciences platform utilizing patient derived cells in various culture formats, phenotypes and genotypes for drug screening assays. Key advantage is testing your compounds/ molecules against the DIVERSITY that will be met in Clinics !!
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OncoPrime - Drug screening platform using patient derived cells
- 1. Adopt cutting edge approaches in Phenotypic Drug Discovery What can be a better model than diseased cells... when that's what we intend to treat !“ Organotypic, 3D cell culture Spheroid, Monolayers & Co-culture Diseased cells from patient samples Cell lines with aberrant mutations not found in primary tumor Target based assays ignore the big picture Will your screening assay system translate to clinics ? Introducing...“ Highly complex More clinically relevant Less physiological Simple Early passage >30 passages SAARUM SCIENCES Phenotypic Platforms for Drug & Biomarker Discovery Do you really know what cells you are working with ? Recent studies suggest that only 40% of established cell lines are useful for drug discovery. Historically most drugs were discovered by phenotypic screens only Primary cell based phenotypic screening is the way to go... OncoPrime TM OncoPrime TM https://www.facebook.com/saarumsciences https://www.linkedin.com/company/saarum-sciences http://twitter.com/saarumsciences
- 2. “ We have a wide range of technology platforms available... “ We Offer Comprehensive Drug Discovery Services... Multicolor Flow cytometry Fluorescent microscopy Confocal microscopy FACS cell sorting Magnetic beads SNP genotyping / SNP arrays Next Generation Sequencing Bioinformatics Pathway / Network Systems biology Biacore CD HPLC GCMS LC-MALDI-TOF X-Ray diffraction FISH IHC IHC-Fr ELISA Karyotyping Sterile fresh cancer tissues are obtained at the biobank after EC approvals and informed consent Customized Primary Cell Phenotypic Assays with complete OMICs data ready for research Explants or Primary Cells are derived from the tissues to obtain a heterogeneous culture Cells are characterized for required parameters including complete pathology reports and used for desired assay(s) 1 2 3 4 OncoPrime TM Screen new chemical or biological entities for optimal efficacy Systematically screen cancers prevalent in India against a 'pill box' Repurpose drugs / combinations to derive novel IP and get to market faster Investigate unique tumor characteristics of Indian patients by gene profiling Generate patient response data by combining in vitro assays with clinical outcomes Saarum Sciences Capabilities 0 20 40 60 80 100 Target identification and selection HTS Preclinical and Phase I studies Phase II studies Phase III studies Disease relevant biological hit Lead optimization in in vitro clinical trials RequiredR&Dprogrammesandresources(US$) Phenotypic drug discovery using patient derived samples Impact of One approved drug
- 3. can be used in multitude of ways... Use our platforms to accelerate your drug discovery pipeline... “ “ In vitro phenotypic assays Derivation of cell lines, engineered platforms Generation of tissue arrays, gene, protein arrays Generation of mouse & zebrafish xenografts Tumor Milieu - with CAFs - with Immune cells - Tumor explants EMT & MET Cancer Stem cells Radiation resistant tumor cells Radiation sensitive tumor cells Chemoresistant tumor cells Novel Biomarker Targets Identify resistance mechanisms The cells are well characterized including morphology, cell surface markers and mutation profile Functional assays like migration, invasion, sphere forming assays etc. can be performed Your molecules could be screened across these phenotypes for target discovery, MOA eludication or in vitro effcacy asessment or drug repurposing or indication selection Versatile phenotypes on offer OncoPrime TM OncoPrime TM Primary cell phenotypic screening assays for phenotypic drug discovery (PDD) Disease modeling & MoA studies using normal and diseased primary cells, CSCs/CTCs, hESCs/iPSCs etc Novel disease models engineered from primary cells (EMT/MET - available; others in pipeline) Toxicology assessment using hESCs and hiPSCs Fresh tissues available across variety of indications & pathologies; Oncology, CNS, CVS, hematology, immunology, dermatology etc FFPE tissue collection for retrospective studies e.g. disease recurrence Overview of fresh tissue collection @ 1 site / 1 yr Breast - Malignant Uterus - Normal Prostate Colon Thyroid Brain - Malignant Breast - Malignant Brain Malignant Uterus - Normal Prostate Colon Thyroid Central Nervous System Respiratory System Immunology Hematology Breast Normal Gastrointestinal System Genitourinary System
- 4. Fast track your drug development process with Primary Cell Based Phenotypic Assays Primary cell panels derived from patient samples for various tumor types Short term cultures retaining clinically relevant features of the disease including tissue heterogeneity, proliferation rate and gene expression profiles Address clinical variability such as different disease stages spanning from pre-cancerous, benign lesions to metastatic cancer Well characterized for driver mutations relevant to patient population Associated medical records (EMR) of the patient for additional information Why choose Saarum Sciences... “ Advantages of using “ Saarum Sciences is an innovative biotech company developing & employing novel primary cell based platforms for phenotypic drug & biomarker discovery applications We have several decades of proven global drug discovery and cell biology expertise across all major therapeutic areas Ongoing collaborations with a wide variety of clientele such as scientific organizations, pharmaceutical & biotech sector, research institutes and CROs Saarum Sciences Pvt. Ltd., Indian Institute for Chemical Technologies Tarnaka, Hyderabad 500007, India. Tel: +91-9704600283, +91-40-20084362 Email: info@saarum.com Website: http://www.saarum.com SAARUM SCIENCES Phenotypic Platforms for Drug & Biomarker Discovery Saarum has a steady inflow of freshly procured & well-annotated patient-derived primary samples through its sister concern Sapien Biosciences Sapien Biosciences, in partnership with Apollo Hospitals (India's largest healthcare provider), has set up India's largest state-of-the-art bio-repository that is systematically acquiring & archiving patient samples under appropriate ethical consent & regulatory approvals OncoPrime TM Request for information: