Oligonucleotides are short DNA or RNA molecules and have specific sequence of nucleotide residue, which makes an entire molecule. Oligonucleotides readily bind in specific sequencing manner to their respective DNA-RNA oligonucleotide to form duplex chain.

1. Oligonucleotide Synthesis Market - Global Industry
Insights, Trends, Outlook, and Opportunity Analysis, 2020
- 2027
Oligonucleotides are short DNA or RNA molecules and have specific sequence of nucleotide
residue, which makes an entire molecule. Oligonucleotides readily bind in specific sequencing
manner to their respective DNA-RNA oligonucleotide to form duplex chain. Oligonucleotides are
chemically synthesized molecular chains with phosphoramidite components of natural or chemically
modified nucleosides and have wide range of applications in generic testing, research, and forensic.
The global oligonucleotide synthesis market is estimated to be valued at US$ 2,874.1 Million in
2020 and is expected to exhibit a CAGR of 11.3% during the forecast period (2020-2027).
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Increasing research and development activities in the field of genomics and genetics is expected to
propel the market growth during the forecast period
Research institutes and diagnostic centers have shifted their focus on genomics and genetics due,
which has increased demand for high quality synthesized oligonucleotides in the market over the
past few years. For instance, in July 2020, researchers of Rosalind Franklin University of
Medicine and Science initiated a new therapeutic approach for treating Batten disease, a fatal
neurodegenerative disease in children with the help of antisense oligonucleotides. These factors are
expected to drive the global oligonucleotide synthesis market growth over the forecast period.

2. Expansion of manufacturing facilities by market players is expected to drive the market growth
during the forecast period
Biotechnological companies are focusing on expanding their manufacturing facilities due to
increasing demand for oligonucleotides from pharmaceutical companies. For instance, in March
2020, STA pharmaceuticals, a subsidiary of WuXi AppTech, announced inauguration of its large
scale oligonucleotide active pharmaceutical ingredient manufacturing facility in China.
Global Oligonucleotide Synthesis Market – Impact of Coronavirus (COVID-19) Pandemic
The coronavirus disease (COVID-19) outbreak was first reported on December 31, 2019, in
Wuhan, China. The World Health Organization declared COVID-19 as pandemic on March 11,
2020.
According to the Coronavirus Disease (COVID-19) Weekly Epidemiological Update by the World
Health Organization, over 61.8 million cases and 1.4 million deaths due to coronavirus disease
(COVID-19) were reported up till November 29, 2020 across the globe.
In order to deal with the COVID-19 pandemic, market players and government authorities are
collaborating, in order to explore the oligonucleotide platform for the development of COVID-19
treatment. For instance, on April 28, 2020, Sarepta Therapeutics, Inc., and the U.S. Army Medical
Research Institute of Infectious Diseases (USAMRIID), a department of defense’s lead laboratory
for medical biological defense research entered into a cooperative research and development
agreement (CRADA) to identify antisense oligonucleotides against SARS-CoV-2 for the potential
treatment of COVID-19.
Global Oligonucleotide Synthesis Market: Restraints
Natural oligonucleotides are composed of ribose or deoxyribose sugar phosphate as a base, which
are quickly degraded in the body by nucleus. Moreover in generic testing, oligo-degradation can
affect cell growth and cell proliferation. Furthermore, low quality of microarray generated
oligonucleotide sequence is a major challenge in adopting microarray technology for oligonucleotide
synthesis. These factors are expected to restrain the global oligonucleotide synthesis market growth.
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Key Players
Major players operating in the global oligonucleotide synthesis market include Thermo Fisher
Scientific, Sigma-Aldrich Corporation, GE Healthcare, Integrated DNA Technologies, Inc., TriLink
BioTechnologies, Inc, BioAutomation Corporation, Twist Bioscience, Shanghai SynTheAll
Pharmaceutical Co., CUSABIO Technology LLC, Synbio Technologies, GENEWIZ, Eurofins
Scientific, Agilent Technologies, Kaneka Eurogentec S.A., and LGC, Biosearch Technologies
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