I'm preparing for friends to visit. They will be arriving soon and I want to make sure everything is ready to welcome them and have a good time together.
The document is a scanned receipt from a grocery store purchase on January 15th, 2023 for $58.46. It lists the items bought which include milk, eggs, bread, cereal, orange juice, bananas, and ground beef. The payment was made with a credit card ending in 4321.
Ecological Risk Assessment Considerations for in planta Expressed and Exogeno...OECD Environment
10-12 April 2019: The OECD Conference on RNAi based pesticides provided an overview on the current status and future possibilities for the regulation of externally applied dsRNA-based products that are proposed for use as pesticides. The event facilitated exchanges between policy makers, academia, industry on their implications in health, environment, and regulation.
This document discusses AlphaFold 2, a new artificial intelligence system developed by DeepMind for protein structure prediction. It summarizes the challenges of studying protein structures due to complexity, time, money and other resources required. It notes that AlphaFold 2 represents a major breakthrough in protein structure prediction, achieving human-level accuracy in predicting protein structures from amino acid sequences alone. The potential impact of this new technology on fields like genomics and proteomics is phenomenal.
ClinVar: Aggregating Data to Improve Variant Interpretation - Melissa LandrumHuman Variome Project
The rate of variant discovery continues to surpass the rate of clinicalgrade interpretation. This is a challenge for precision medicine, because fast, reliable access to variant interpretations is necessary to provide well-informed and timely interpretations of test results to patients. ClinVar is a public repository for interpretations of clinical significance and functional effects of variants in any gene and for any disease. Interpretations are submitted by many sources, including clinical testing laboratories, research laboratories, locus-specific databases, expert panels, practice guidelines, as well as OMIM® and GeneReviews™. Collecting variant interpretations in ClinVar depends on integrating data from these different sources, which has several benefits. First, data integration requires standardizing the data from each source. This improves the quality of the data in ClinVar as well as in each of the individual datasets. ClinVar staff validate HGVS expressions as a routine part of ClinVar submission processing. Submitters are encouraged to use standard terms in MedGen for diseases and phenotypes. Standard terms for clinical significance are used in ClinVar when available; for example, ClinVar uses the terms recommended by ACMG to classify variants for Mendelian diseases. Secondly, ClinVar aggregates all data for a variant defined by its genomic location. Therefore, HGVS descriptions on different transcripts or on different genomic sequences can be recognized as the same variant. Thirdly, integrating data from multiple submitters allows the evidence from all sources to be pooled together. This larger collection of evidence aids the re-evaluation of variant classifications, and is especially valuable for rare variants and novel gene-disease relationships. Fourthly, data integration means that variant interpretations from different sources can be viewed together and compared. Thus a ClinVar user has access to interpretations outside any internal system and knows when there is consensus in the interpretation or not. Submitting laboratories use reports of conflicting interpretations in ClinVar to prioritize variants that they should re-evaluate. ClinVar receives data from many data providers, and therefore provides clear attribution to each contributing group, including links to records in LSDBs. Each source may update their submission to ClinVar at any time. For example, a record may be updated when a variant is re-classified or when additional evidence is available to support the interpretation. Submitters may consider providing regular updates to ClinVar to prevent their interpretations from becoming out of date. Submissions to ClinVar describe variants that range in complexity from simple alleles with explicit sequence locations through copy number changes and cytogenetic rearrangements with fuzzy boundaries.
OECD Global Forum on the Environment dedicated to Per- and Polyfluoroalkyl Su...OECD Environment
PFAS, which stands for per- and polyfluoroalkyl substances, are a diverse group of chemicals that include PFCAs, PFOA, PFSAs, PFHxS, and thousands of others. These chemicals have been in commercial production since the 1950s and are now widely used in consumer and industrial applications. One characteristic of PFAS is their persistence in the environment, as they are extremely resistant to degradation. PFAS have emerged as contaminants of global concern because of their potential to accumulate in the human body and food chains.
On 12-13 February 2024, a wide range of stakeholders, including governments, industry, non-governmental organisations (NGOs), and academics came together to discuss various topics related to PFAS. These topics covered areas such as country risk management approaches, innovation challenges for finding safer alternatives, effective risk communication strategies, monitoring techniques, waste management, and approaches to managing contamination.
This document discusses protein structure prediction and molecular modeling. It begins with an overview of the druggable genome and protein structure prediction approaches such as ab initio modeling, threading, and homology modeling. It then provides details on homology modeling steps including searching databases, selecting templates, aligning sequences, building models, and model evaluation. The document also discusses protein-ligand docking, scoring functions, assessing docking performance, and practical aspects of docking such as protein and ligand preparation.
Genome editing uses engineered nucleases to make targeted changes to DNA. There are several methods for engineered nucleases: zinc finger nucleases (ZFNs) use zinc finger proteins fused to FokI nuclease; transcription activator-like effector nucleases (TALENs) use transcription activator-like effector proteins fused to FokI; meganucleases are naturally occurring enzymes; and CRISPR/Cas uses a bacterial adaptive immune system. These nucleases make double-stranded breaks that are repaired through non-homologous end joining or homology-directed repair, allowing changes like gene knockouts, insertions, or replacements. Examples showed using these methods in plants and animals. Each method
This is a presentation slide about cellular RNA interference process and RNA interference technology. Contains basic information about biology of cellular RNA interference processes and its discovery, and RNA interference technology. Also gives you the history and development of in-vitro and in-vivo technologies for applicability of RNA interference technology.
siRNA synthesis, siRNA libraries, siRNA delivering techniques, Electroporation, viral transfection methods, Advantages and disadvantages of RNA interference technology.
details about the preliminary and pre-clinical experiments of RNA interference as well as clinical trials of RNA interference.
The document is a scanned receipt from a grocery store purchase on January 15th, 2023 for $58.46. It lists the items bought which include milk, eggs, bread, cereal, orange juice, bananas, and ground beef. The payment was made with a credit card ending in 4321.
Ecological Risk Assessment Considerations for in planta Expressed and Exogeno...OECD Environment
10-12 April 2019: The OECD Conference on RNAi based pesticides provided an overview on the current status and future possibilities for the regulation of externally applied dsRNA-based products that are proposed for use as pesticides. The event facilitated exchanges between policy makers, academia, industry on their implications in health, environment, and regulation.
This document discusses AlphaFold 2, a new artificial intelligence system developed by DeepMind for protein structure prediction. It summarizes the challenges of studying protein structures due to complexity, time, money and other resources required. It notes that AlphaFold 2 represents a major breakthrough in protein structure prediction, achieving human-level accuracy in predicting protein structures from amino acid sequences alone. The potential impact of this new technology on fields like genomics and proteomics is phenomenal.
ClinVar: Aggregating Data to Improve Variant Interpretation - Melissa LandrumHuman Variome Project
The rate of variant discovery continues to surpass the rate of clinicalgrade interpretation. This is a challenge for precision medicine, because fast, reliable access to variant interpretations is necessary to provide well-informed and timely interpretations of test results to patients. ClinVar is a public repository for interpretations of clinical significance and functional effects of variants in any gene and for any disease. Interpretations are submitted by many sources, including clinical testing laboratories, research laboratories, locus-specific databases, expert panels, practice guidelines, as well as OMIM® and GeneReviews™. Collecting variant interpretations in ClinVar depends on integrating data from these different sources, which has several benefits. First, data integration requires standardizing the data from each source. This improves the quality of the data in ClinVar as well as in each of the individual datasets. ClinVar staff validate HGVS expressions as a routine part of ClinVar submission processing. Submitters are encouraged to use standard terms in MedGen for diseases and phenotypes. Standard terms for clinical significance are used in ClinVar when available; for example, ClinVar uses the terms recommended by ACMG to classify variants for Mendelian diseases. Secondly, ClinVar aggregates all data for a variant defined by its genomic location. Therefore, HGVS descriptions on different transcripts or on different genomic sequences can be recognized as the same variant. Thirdly, integrating data from multiple submitters allows the evidence from all sources to be pooled together. This larger collection of evidence aids the re-evaluation of variant classifications, and is especially valuable for rare variants and novel gene-disease relationships. Fourthly, data integration means that variant interpretations from different sources can be viewed together and compared. Thus a ClinVar user has access to interpretations outside any internal system and knows when there is consensus in the interpretation or not. Submitting laboratories use reports of conflicting interpretations in ClinVar to prioritize variants that they should re-evaluate. ClinVar receives data from many data providers, and therefore provides clear attribution to each contributing group, including links to records in LSDBs. Each source may update their submission to ClinVar at any time. For example, a record may be updated when a variant is re-classified or when additional evidence is available to support the interpretation. Submitters may consider providing regular updates to ClinVar to prevent their interpretations from becoming out of date. Submissions to ClinVar describe variants that range in complexity from simple alleles with explicit sequence locations through copy number changes and cytogenetic rearrangements with fuzzy boundaries.
OECD Global Forum on the Environment dedicated to Per- and Polyfluoroalkyl Su...OECD Environment
PFAS, which stands for per- and polyfluoroalkyl substances, are a diverse group of chemicals that include PFCAs, PFOA, PFSAs, PFHxS, and thousands of others. These chemicals have been in commercial production since the 1950s and are now widely used in consumer and industrial applications. One characteristic of PFAS is their persistence in the environment, as they are extremely resistant to degradation. PFAS have emerged as contaminants of global concern because of their potential to accumulate in the human body and food chains.
On 12-13 February 2024, a wide range of stakeholders, including governments, industry, non-governmental organisations (NGOs), and academics came together to discuss various topics related to PFAS. These topics covered areas such as country risk management approaches, innovation challenges for finding safer alternatives, effective risk communication strategies, monitoring techniques, waste management, and approaches to managing contamination.
This document discusses protein structure prediction and molecular modeling. It begins with an overview of the druggable genome and protein structure prediction approaches such as ab initio modeling, threading, and homology modeling. It then provides details on homology modeling steps including searching databases, selecting templates, aligning sequences, building models, and model evaluation. The document also discusses protein-ligand docking, scoring functions, assessing docking performance, and practical aspects of docking such as protein and ligand preparation.
Genome editing uses engineered nucleases to make targeted changes to DNA. There are several methods for engineered nucleases: zinc finger nucleases (ZFNs) use zinc finger proteins fused to FokI nuclease; transcription activator-like effector nucleases (TALENs) use transcription activator-like effector proteins fused to FokI; meganucleases are naturally occurring enzymes; and CRISPR/Cas uses a bacterial adaptive immune system. These nucleases make double-stranded breaks that are repaired through non-homologous end joining or homology-directed repair, allowing changes like gene knockouts, insertions, or replacements. Examples showed using these methods in plants and animals. Each method
This is a presentation slide about cellular RNA interference process and RNA interference technology. Contains basic information about biology of cellular RNA interference processes and its discovery, and RNA interference technology. Also gives you the history and development of in-vitro and in-vivo technologies for applicability of RNA interference technology.
siRNA synthesis, siRNA libraries, siRNA delivering techniques, Electroporation, viral transfection methods, Advantages and disadvantages of RNA interference technology.
details about the preliminary and pre-clinical experiments of RNA interference as well as clinical trials of RNA interference.
This document provides a grammar lesson on comparative and superlative adjectives. It explains that comparative adjectives compare two items using -er or more, while superlative adjectives compare three or more items using -est or most. It lists rules for forming regular and irregular comparative and superlative forms and examples like strange, stranger, strangest and good, better, best. The document concludes with notes not to use more or most with -er or -est forms.
The document describes a journey to the center of the Earth and details a spelling lesson for the 55th date. It provides information about a particular plan or intention to project and describes giving an account in words of someone or something, including all the relevant characteristics, qualities, or events.
Journey to the center of the earth vocabulary lessonamac24
This vocabulary lesson introduces 6 words from Journey to the Center of the Earth: armor which means any kind of protective covering, encases which means to cover completely or enclose, extinct which means no longer existing, hideous which means very ugly or frightful, plunged which means to fall or move suddenly downward or forward, and serpent which means a snake, especially a big snake.
Adjectives describe nouns and pronouns by indicating kind, number, or identity. Articles like "a", "an", and "the" precede nouns and adjectives, with "a" used before consonant sounds, "an" before vowel sounds or silent h's, and "the" before any letter. Adjectives formed from proper nouns are called proper adjectives and are capitalized, such as referring to a ship as "British".
This document contains spelling lessons on various words related to music, signals, speed, protection, magic, jobs, and electricity. Some of the words included are music, musician, select, signal, part, haste, protect, protection, magic, magician, resign, resignation, electric, and electrician. The document provides definitions for each word in list format.
This document contains a vocabulary lesson about terms related to the Titanic shipwreck. It defines 10 words - robotic, interior, cramped, ooze, sediment, sonar, and debris - that describe features of the Titanic wreck site on the ocean floor or tools used to explore it.
This document provides a grammar lesson on comparative and superlative adjectives. It explains that comparative adjectives compare two items using -er or more, while superlative adjectives compare three or more items using -est or most. It lists rules for forming regular and irregular comparative and superlative forms and examples like strange, stranger, strangest and good, better, best. The document concludes with notes not to use more or most with -er or -est forms.
The document describes a journey to the center of the Earth and details a spelling lesson for the 55th date. It provides information about a particular plan or intention to project and describes giving an account in words of someone or something, including all the relevant characteristics, qualities, or events.
Journey to the center of the earth vocabulary lessonamac24
This vocabulary lesson introduces 6 words from Journey to the Center of the Earth: armor which means any kind of protective covering, encases which means to cover completely or enclose, extinct which means no longer existing, hideous which means very ugly or frightful, plunged which means to fall or move suddenly downward or forward, and serpent which means a snake, especially a big snake.
Adjectives describe nouns and pronouns by indicating kind, number, or identity. Articles like "a", "an", and "the" precede nouns and adjectives, with "a" used before consonant sounds, "an" before vowel sounds or silent h's, and "the" before any letter. Adjectives formed from proper nouns are called proper adjectives and are capitalized, such as referring to a ship as "British".
This document contains spelling lessons on various words related to music, signals, speed, protection, magic, jobs, and electricity. Some of the words included are music, musician, select, signal, part, haste, protect, protection, magic, magician, resign, resignation, electric, and electrician. The document provides definitions for each word in list format.
This document contains a vocabulary lesson about terms related to the Titanic shipwreck. It defines 10 words - robotic, interior, cramped, ooze, sediment, sonar, and debris - that describe features of the Titanic wreck site on the ocean floor or tools used to explore it.