For patients who are pregnant, the NIPT is a simple, safe and noninvasive way to screen for common chromosomal conditions. https://goo.gl/LrbTnp

1. a new life. well planned.
non-invasive
prenatal test
Provide the best clarity and reassurance
to your patients.

2. Claria
From MedGenome
MedGenome is driven to enable clinicians to deliver the bes t outcomes to
their patients. Our passion to deliver actionable insights to clinicians has
resulted in the development of “Claria” - a suite of NGS (Next-Generation
Sequencing) technology-bas ed solutions for reproductive testing.
Claria offers the most accurate Non-Invasive Prenatal Screening Test (NIPT),
the Genetic Carrier Screening Test and the Preimplantation Genetic
Screening/Diagnosis (PGS/PGD).
Additionally, Claria offers an absolutely free, on-demand pre and post-test
genetic counselling to all your patients.
Carrier Screening
Test
Preimplantation
Genetic Screening
Non-Invasive
Prenatal Screening
test

3. Claria NIPT now screens for microdeletions
Chromosomal abnormalities in India
Claria NIPT
MedGenome Claria NIPT is a simple, safe and non-invasive prenatal screening test that
provides assurance to expectant parents with accurate genetic information about their baby.
This screening test can be performed from as early as the 9th week of a pregnancy. Compared
higher sensitivity and lower false positive rate for the conditions screened.
Claria NIPT now covers clinically relevant microdeletions that occur in 1-1.7% of all
deletion exceeds the risk for Down syndrome. These sub-chromosomal abnormalities
which collectively have a population incidence of approximately 1 in 1000 will result in
severe physical and /or intellectual impairments.
A woman’s risk of having a term pregnancy with certain chromosomal abnormalities
increases with age.
risk for Down syndrome
• High prevalence of chromosomal abnormalities: 1 in 200 births
• Over 25 million births every year in India
• Over 130,000 births with chromosomal abnormalities in India
every year
• Incidence of Down Syndrome is 1 in 850 live births in India
• 1 in 1000 is the population incidence for microdeletions, the
disorders included are 22q11.2 deletion syndrome, 1p36 deletion
syndrome, Cri du chat syndrome, Prader-Willi syndrome,
Angel man syndrome*
* Combined prevalence using higher end of published ranges from Gross et al. Prenatal Diagnosis
2011; 39, 259-266; and www.genetests.org. Total prevalence may range from 1/1071 - 1/2206.

4. The risk of having a baby with Down Syndrome*
For a 26 yr old woman:1 in 1300
For a 36 yr old woman:1 in 270
The risk factor increases by almost5x
However, the incidence of microdeletions is independent of maternal age.
Incidence of microdeletions at birth
Maternal Age
Down Syndrome1
Panorama Microdeletions Panel2
1/250
1/500
1/1000
1/2000
20 24 28 3222 26 30 34
syndrome live births. Prenat Diagn. 2003 Mar;23(3):252-8.
1 Snijders, et al. Ultrasound Obstet Gynecol 1999; 13: 167-170.
2 Combined prevalence using higher end of published ranges from Gross et al. Prenatal Diagnosis
2011; 39, 259-266; and www.genetests.org. Total prevalence may range from 1/1071 - 1/2206.

5. Why screening is important
Claria NIPT does not test for the gender of the foetus.
Aneuploidy Microdeletions
What are the chromosomal and structural
anomalies detected by Claria NIPT?
Common aneuploidies T21, T18, T13, Sex Chromosomes abnormalities, triploidy and
5 common microdeletion syndromes from fetal DNA obtained from maternal blood.
Unlike other tests, Claria NIPT also tests for triploidy and vanishing twin. It is the only test
that differentiates between maternal and fetal DNA, which helps avoid false positives.
• Trisomy 21 (Down Syndrome)
• Trisomy 18 (Edwards’ Syndrome)
• Trisomy 13 (Patau syndrome)
• Triploidy
• Monosomy X (Turner Syndrome)
• Klinefelter Syndrome, Triple X
Syndrome, Jacob’s Syndrome
• 22q11.2 Deletion Syndrome
• 1p36 Deletion Syndrome
• Prader-Willi Syndrome
• Angelman Syndrome
• Cri-du-chat Syndrome
• Reassurance for expecting parents
• Early information for better management
• Preparation for the birth and early
intervention wherever possible

6. Why Claria NIPT?
Over 99.9% accuracy
Can be screened from as early as the 9th
week
of a pregnancy.
A simple, and safe blood draw from mothers arm,
posing no risk to the foetus
The only SNP technology based NIPT in India
Reports foetal fraction in each case
FREE Pre & Post test genetic counseling for all patients
The only lab to process NIPT samples in India, enabling for
accurate and faster reporting.

7. Who is Claria NIPT for?
• The woman is above 30 years of age
• An abnormal ultrasound report
• Couples with a family history of chromosomal conditions
or birth defects
• Couples who have had a child with a chromosomal disorder
• Couples with a history of infertility or pregnancy loss
(miscarriages or stillbirths)
All pregnant women who need insight into their baby’s development can avail the test,
regardless of their age. Claria NIPT is recommended for all pregnancies.
-
nancies, irrespective of the risk. For physicians, it is important to recommend
this test for pregnancies where:

8. Test accuracy: 75-90% Test accuracy: >99.9%
False positives: 5% False positives: <0.1%
Affected, undetected
cases: 10-15%
Affected, undetected
cases: <0.1%
Can only be done from the
11th
week onwards and
within certain gestational
time frames
Can be done from as
early as the 9th
week
of pregnancy
Traditional screening test Claria NIPT
Traditional screening
test vs. Claria NIPT

9. Claria NIPT in 5 simple steps
1. Ask about Claria NIPT
2. Quick and simple blood draw
3. Receive highly accurate reports
4. Review the test results
5. Get in touch with us for counselling
To book the test, dial 1800 -1037590 or visit www.medgenomeclaria.com and we will
help you locate the sample collection centre closest to your patient.
A small sample of blood is drawn from the mother’s arm. This is a non-invasive proce-
dure and poses no risk to the baby.
Medgenome is the only lab enabled to process NIPT samples in India. This ability allows
for high accuracy and faster reporting.3. Receive highly accurate reports
Our Genetic Counsellor and Scientists will help you understand the detailed report and guide you accordingly.
session with one of our genetic counselling experts.

10. The Claria NIPT advantage for your patients
Order now
The CLARIA NIPT ADVANTAGE for your patients:
• Over 99.9% accuracy
• Can be screened from as early as 9th week of a pregnancy
• A simple, and safe blood draw from mothers arm, posing
no risk to the foetus
• The only SNP technology based NIPT in India
• Reports foetal fraction in each case
• FREE Pre & Post test genetic counseling for all patients
• The only lab to process NIPT samples in India, enabling for
accurate and faster reportingv
MedGenome Labs Pvt. Ltd.
3rd Floor, Narayana Netralaya Building,
Narayana Health City, #258/A,
Bommasandra, Hosur Road,
Bangalore – 560099
Toll free no: 1800-1037590 | SMS ‘CLARIA’ to 56767
www.medgenomeclaria.com | doctorsupport@medgenomeclaria.com