Prostate cancer diagnoses and deaths remain high, with unmet needs in early detection, locally advanced and metastatic treatment. A new therapeutic approach is being developed through the PRO-NET Consortium to address these needs using a multi-marker diagnostic and combination therapy targeting multiple pathways. Forming an independent company is seen as essential to securing intellectual property and pursuing venture capital funding to support clinical trials and market entry, with forecasts of substantial revenues and market share within 5 years if successful.