1. C E L L D E A T H I N P A R K I N S O N ’ S
D I S E A S E

2. T H E B A S I C S

3. S Y M P T O M S

4. P A R T O N E : T H E M I T O C H O N D R I A
• we are all aware that the mitochondria takes simpler
molecules of nutrition and processes them to produce
charged molecules. These charged molecules combine
with oxygen and produce ATP molecules.
• however, the mitochondria also has other functions that
(when malfunction) cause significant damage to the
cell and may even cause cell death.

5. O T H E R F U N C T I O N S O F T H E
M I T O C H O N D R I A

6. M I T O C H O N D R I A L M O R P H O L O G Y A N D
C E L L D E A T H

7. P I N K 1 D E G R A D A T I O N

8. A L P H A - S Y N U C L E I N

9. L E W Y B O D I E S

10. A - S Y N R O L E O N C E L L D E A T H

11. E X C I T O T O X I C I T Y

12. O X I D A T I V E S T R E S S

13. S U M M A R Y
• parkinson’s disease causes motor and non-motor
symptoms.
• there is significant interplay between protein
degradation pathways and the pathogenesis of PD
• the dysfunction of mitochondria and a-syn work hand in
hand in the progression of PD and cell death.