This article aims to demonstrate that neofascism and neoimperialism are manifestations of the final crisis of capitalism from the mid-21st century onwards. These two political phenomena are caused by the structural crisis of capitalism in its final stage. Neofascism is a political response at the domestic level of each country, and neoimperialism is a geopolitical response at the global level to the final crisis of the world capitalist system. Several scholars of capitalism, such as Karl Marx, Vladimir Lenin, Immanuel Wallerstein, Giovanni Arrighi, David Harvey, Samir Amin, István Mészáros, Ellen Wood, among others, argue that capitalism has experienced structural contradictions from the end of the 19th century to the contemporary era, such as the tendency of the rate of profit to fall, the shift of investments from the productive sector to the financial sector, the overaccumulation of capital in the growing search for new frontiers of exploitation, the increasing and explosive social inequality within central and peripheral capitalist countries, the erosion of the post-1945 liberal order, the current environmental crisis that sets limits to unlimited economic growth, and the competition between the great powers for world hegemony. These events created the historical context in which imperialism emerged in the mid-19th century and fascism and Nazism in the first half of the 20th century, as well as neo-fascism and neo-imperialism in the contemporary era. This article demonstrates that the final crisis of capitalism will occur from the mid-21st century onwards, that neofascism is the political response in each country to the final crisis of capitalism from the mid-21st century onwards, and that neoimperialism is the geopolitical response at the global level to the final crisis of capitalism from the mid-21st century onwards.