Wilt Chamberlain holds the records for most points scored in a single NBA game with 100 points and also scored 78, 73, and 72 points in other games, demonstrating his ability to score at an exceptionally high level throughout his career. Kobe Bryant is second on the list with 81 points scored in a single game, underscoring his tremendous scoring talent, though he did not surpass Wilt Chamberlain's record-setting performance.