Nepal has successfully reduced under-five mortality and neonatal mortality through various programs. About two in five neonatal deaths occur on the first day of life, and over eight in ten in the first week. The most common causes of neonatal death are sepsis, birth asphyxia, hypothermia, low birth weight, and prematurity. National programs addressing maternal and child health include the Safe Motherhood Program, Integrated Management of Childhood Illness, bi-annual vitamin A supplementation, and immunization. Strategies to further reduce mortality focus on birth preparedness, institutional delivery, and expanding emergency obstetric care. Major challenges include inadequate skilled birth attendants, poor quality of care, and lack of funding and infrastructure especially for