Radiochemical Methods of Analysis: Origin and nature of radioactive isotopes, natural and induced radioactivity, radioactive decay, different type of radiation, radiation detection and their measurement, principles of Geiger-Muller, Scintillation and proportion counters, radio- activation analysis, isotope dilution analysis, characterization, methodology and use of radiometric titrations in pharmaceutical research.
Radiochemical Methods of Analysis: Origin and nature of radioactive isotopes, natural and induced radioactivity, radioactive decay, different type of radiation, radiation detection and their measurement, principles of Geiger-Muller, Scintillation and proportion counters, radio- activation analysis, isotope dilution analysis, characterization, methodology and use of radiometric titrations in pharmaceutical research.
Polarography: Principle, component of polarogram, Ilkovic equation, diffusion current factor affection affusion current and half wave potential, quantitative analysis and applications. plarographic maxima supprissor, oxygen wave, supporting electrolyte.
4. Drug Clearance:
a) Theoretical aspects of drug elimination, excretion and biotransformation.
b) Renal Elimination: Glomerular filtration, active tubular secretion, tubular reabsorption. Determination of renal clearance.
c) Biotransformation of Drugs: Definition, drug biotransformation reactions, pharmacokinetics of drugs and metabolites (Michelis Menten equation), hepatic elimination, first pass effect, liver excretion ratio, relation between absolute bioavailability and liver excretion, hepatic clearance- relationship between blood flow, intrinsic clearance and hepatic clearance, hepatic clearance of a protein bound drug (effect of protein binding on hepatic clearance).
d) Biliary excretion of drug.
Define topology and explain different types of topologies of the network?
Explain error detection and error correction techniques?
Explain the flow control mechanism?
Polarography: Principle, component of polarogram, Ilkovic equation, diffusion current factor affection affusion current and half wave potential, quantitative analysis and applications. plarographic maxima supprissor, oxygen wave, supporting electrolyte.
4. Drug Clearance:
a) Theoretical aspects of drug elimination, excretion and biotransformation.
b) Renal Elimination: Glomerular filtration, active tubular secretion, tubular reabsorption. Determination of renal clearance.
c) Biotransformation of Drugs: Definition, drug biotransformation reactions, pharmacokinetics of drugs and metabolites (Michelis Menten equation), hepatic elimination, first pass effect, liver excretion ratio, relation between absolute bioavailability and liver excretion, hepatic clearance- relationship between blood flow, intrinsic clearance and hepatic clearance, hepatic clearance of a protein bound drug (effect of protein binding on hepatic clearance).
d) Biliary excretion of drug.
Define topology and explain different types of topologies of the network?
Explain error detection and error correction techniques?
Explain the flow control mechanism?
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