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SIMON N. MUCHOHI
Ph.D. MPH, M.Sc., B.Sc., CSP, CHMM
LIST OF PUBLICATIONS IN PEER-REVIEWED SCIENTIFIC JOURNALS
1. Gwer, S.A., Idro, R.I., Fegan. G., Chengo, E.M., Mpoya, A., Kivaya, E., Crawley, J., MUCHOHI, S.N.,
Kihara, M., Ogutu, B.R., Kirkham, F.J., CR Newton, C.R. (2013). “Fosphenytoin for seizure prevention in
childhood coma in Africa: a randomized clinical.” Journal of Critical Care; 28 (6), 1086-1092.
2. Mbuba, C.K., Ngugi, A.K. Greg Fegan, G. Fredrick Ibinda, F., MUCHOHI, S.N., Nyundo, C., Odhiambo,
R., Edwards, T., Odermatt, P. Carter, J.A., Newton, C.R. (2012). Risk factors associated with the epilepsy
treatment gap in Kilifi, Kenya: a cross-sectional study. The Lancet Neurology; 11(8): 688-696.
3. Chilengi, R., Juma, R., Abdallah, A.M., Bashraheil, M., Lodenyo, H., Nyakundi, P., Anabwani, E., Salim,
A., Mwambingu, G., Wenwa, E., Jemutai, J., Kipkeu, C., Oyoo, G.O., MUCHOHI, S.N., Kokwaro, G.,
Niehues, T., Lang, T. and Nzila, A. (2011). A phase I trial to evaluate the safety and pharmacokinetics of
low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers. Malaria Journal 10:
63.
4. Mbuba, CK; Ngugi, AK; MUCHOHI, SN; Edwards, T.; Odermatt, P.; Carter, JA; Newton, CR (2011). The risk factors
for epilepsy treatment gap and non-adherence to antiepileptic drugs in Kilifi, Kenya. Epliepsia; 52: 13 – 13.
5. Thuo, N., Ungphakorn, W., Karisa, J., MUCHOHI, S., Muturi, A., Kokwaro, G., Thomson, A.H. and
Maitland, K. (2011). Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a
population pharmacokinetic study with Monte Carlo simulation. Journal of Antimicrobial Chemotherapy
66(10): 2336-2345.
6. MUCHOHI, S.N., Thuo, N., Karisa, J., Muturi, A., Kokwaro, G.O. and Maitland, K. (2010). Determination
of ciprofloxacin in human plasma using high-performance liquid chromatography coupled with
fluorescence detection: application to a population pharmacokinetics study in children with severe
malnutrition. Journal of Chromatography B Analytical Technology Biomedical Life Science 879(2): 146-
152.
7. Ikumi, M., MUCHOHI, S., Ohuma, E., Kokwaro, G. and Newton, C. (2009). Outcome of the Management
of Acute Seizures in Children Admitted to A District Hospital in Sub-Saharan Africa. Epilepsia 50 (Suppl.
10): 158-159.
8. Ikumi, M.L., MUCHOHI, S.N., Ohuma, E.O., Kokwaro, G.O. and Newton, C.R. (2008). Response to
diazepam in children with malaria-induced seizures. Epilepsy Research 82(2-3): 215-218.
9. MUCHOHI, S.N., Kokwaro, G.O., Ogutu, B.R., Edwards, G., Ward, S.A. and Newton, C.R. (2008).
"Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions."
British Journal of Clinical Pharmacology 66(4): 529-538.
10. MUCHOHI, S.N., Obiero, K., Newton, C.R., Ogutu, B.R., Edwards, G. and Kokwaro, G.O. (2008).
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.
British Journal of Clinical Pharmacology 65(1): 12-21.
11. Teka, H., Petros, B., Yamuah, L., Tesfaye, G., Elhassan, I., MUCHOHI, S., Kokwaro, G., Aseffa, A. and
Engers, H. (2008). Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia. Malaria
Journal 7: 220.
12. Seaton, C., Ignas, J., MUCHOHI, S., Kokwaro, G., Maitland, K. and Thomson, A.H. (2007). Population
pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition.
Journal of Antimicrobial Chemotherapy 59(4): 681-689.
13. Kokwaro, G.O., MUCHOHI, S.N., Ogutu, B.R. and Newton, C.R. (2006). Chloramphenicol
pharmacokinetics in African children with severe malaria. Journal of Tropical Pediatrics 52(4): 239-243.
14. MUCHOHI, S.N., Obiero, K., Kokwaro, G.O., Ogutu, B.R., Edwards, G. and Ward, S.A. (2006).
Pharmacokinetics and clinical efficacy of midazolam and lorazepam in Kenyan children. 27th African
Health Sciences Congress, 3-6 December 2006, Durban, South Africa.
15. MUCHOHI, S.N., Obiero, K., Kokwaro, G.O., Ogutu, B.R., Githiga, I.M., Edwards, G. and Newton, C.R.
(2005). Determination of lorazepam in plasma from children by high-performance liquid chromatography

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with UV detection. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life
Sciences 824(1-2): 333-340.
16. MUCHOHI, S.N., Ward, S.A., Preston, L., Newton, C.R., Edwards, G. and Kokwaro, G.O. (2005).
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid
chromatography-electrospray mass spectrometry in plasma from children. Journal of Chromatography B,
Analytical Technologies in the Biomedical and Life Sciences 821(1): 1-7.
17. Kokwaro, G.O., Ogutu, B.R., MUCHOHI, S.N., Otieno, G.O. and Newton, C.R. (2003). Pharmacokinetics
and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions. British
Journal of Clinical Pharmacology 56(4): 453-457.
18. Ogutu, B.R., Newton, C.R., MUCHOHI, S.N., Otieno, G.O., Edwards, G., Watkins, W.M. and Kokwaro,
G.O. (2003). Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe
malaria and status epilepticus. British Journal of Clinical Pharmacology 56(1): 112-119.
19. Thomson, A.H., Kokwaro, G.O., MUCHOHI, S.N., English, M., Mohammed, S. and Edwards, G. (2003).
Population pharmacokinetics of intramuscular gentamicin administered to young infants with suspected
severe sepsis in Kenya. British Journal of Clinical Pharmacology 56(1): 25-31.
20. MUCHOHI, S.N., Kokwaro, G.O., Maitho, T.E., Munenge, R.W., Watkins, W.M. and Edwards, G. (2002).
Pharmacokinetics of phenytoin following intravenous and intramuscular administration of fosphenytoin
and phenytoin sodium in the rabbit." European Journal of Drug Metabolism and Pharmacokinetics 27(2):
83-89.
21. Ogutu, B.R., Newton, C.R., Crawley, J., MUCHOHI, S.N., Otieno, G.O., Edwards, G., Marsh, K. and
Kokwaro, G.O. (2002). Pharmacokinetics and anticonvulsant effects of diazepam in children with severe
falciparum malaria and convulsions. British Journal of Clinical Pharmacology 53(1): 49-57.
22. Muchohi, SN; Kokwaro, GO; Maitho, TE; Munenge, RW; Watkins, WM; Edwards, G. (2002).
Pharmacokinetics of phenytoin following intravenous and intramuscular administration of fosphenytoin
and phenytoin sodium in the rabbit. European. Journal of Drug Metabolism and Pharmacokinetics; 27(2):
83-89.
23. Ogutu, B.R.; Newton, C.R.J.C.; Muchohi, S.N.; Otieno, G.O.; Kokwaro, G.O. (2002). Phenytoin
pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol
coadministration. British Journal of Clinical Pharmacology; 54(6): 635
24. Muchohi, SN; Ogutu, BR; Newton, C.; Kokwaro, GO (2001). High-performance liquid chromatographic
determination of diazepam in plasma of children with severe malaria. Journal of Chromatography B:
Biomedical Sciences and Applications; 761(2): 255-259.
25. Ungphakorn, W.; Thuo, N.; Muturi, N.; Karisa, J.; Muchohi, S.; Kokwaro, G.; Thomson, AH; Maitland, K.
IV-31 Wanchana Ungphakorn Population Pharmacokinetics and Use of Monte Carlo Simulation to
Determine Optimal Dosing Regimen of Oral Ciprofloxacin in Paediatric Patients with Severe Malnutrition.
Abstracts of the Annual Meeting of the Population Approach Group in Europe. PAGE 20 (2011) Abstract
2080.
SELECTED PRESENTATIONS AT CONFERENCES/WORKSHOPS
1. MUCHOHI SN, Kortok MM, Morpeth S, Lowe B, and Peshu N (2010). Establishing Occupational Health
and Safety Management System in a Biomedical Research Setting in Kenya. 1st African Biological
Safety Association Conference, 8-12th March 2010. KEMRI Training Centre, Nairobi, Kenya.
2. MUCHOHI SN, Njuguna PW, Kokwaro GO, Edwards G, and Newton CRJC (2009). Pharmacokinetics of
paracetamol in children with fever associated with severe malaria. Presented at the Fifth Multilateral
Initiative on Malaria (MIM) Pan-African Malaria Conference, Kenyatta International Conference
Centre, Nairobi, Kenya (November 02–06, 2009).
3. MUCHOHI SN, Obiero KO, Kokwaro GO, Ogutu BR, Edwards G, Ward SA, Newton CR (2006).
Pharmacokinetics and clinical efficacy of midazolam and lorazepam in Kenyan children. Presented at the
27th African Health Sciences Congress, 3rd-7th Dec 2006, Durban, South Africa.
4. MUCHOHI S, Obiero K, Kokwaro G, Ogutu B, Ward S, Edwards G, & Newton C (2005).
Pharmacokinetics of midazolam and lorazepam in Kenyan children with severe malaria and convulsions.
Presented as a poster at the Fourth Multilateral Initiative on Malaria (MIM) Pan-African Malaria
Conference, Yaounde, Cameroon [13-18 Nov 2005]. Presented as a poster [MIM-MN-175440; Poster
221B]. Abstract published in Acta Tropica (2005) Suppl 95S: S225.