mRNA vaccine-6

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Types of mRNA vaccine Non replicating mRNA Encoding the antigen of interest and contains 5′ and 3′ untranslated regions (UTRs) https://www.creative-biolabs.com/vaccine/mrna-vaccine-platform.htm

Health & Medicine

Types of mRNA vaccine
 Non-replicating mRNA
 Self-amplifying mRNA
Regulatory elements in 5'U T R and 3'U T R stabilize
mRNA and increase antigen protein translation.
5’-G
Cap enables mRNA to
translate in the right
direction.
Poly A can increase the mRNA
stability and the expression of antigen
protein, playing an important role in
the translation and stability of mRNA.
P P P UTR SP ORF UTR AAAAAA(140-150)-3’
CAP 5‘Untranslated Region 3‘Untranslated Region Poly A Tail
Open Reading Frame
Open reading frame is a nucleic acid
sequence that encodes antigens.

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While conventional cancer therapies (surgery, chemo therapy, and radiation therapy) have shown some success in the battle again cancer, they are often accompanied by complex and sometimes, severe side-effects due to the lack of target specificity. To circumvent this flaw and improve the efficacy and safety of cancer treatment, targeted cancer therapies, especially antibody-drug conjugates (ADCs), have been actively exploited and they are gaining a significant amount of attention during the recent years.https://www.creative-biolabs.com/adc/adc-antibody-screening.htm

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The elegant design of an antibody-drug conjugate is designated to achieve targeted delivery of the conjugated cytotoxic agents to tumor cells and drug release upon antigen binding and internalization, thus maximizing the antitumor effects while minimizing cytotoxicity to normal tissues. The efficacy of an ADC greatly depends on the specific antigen binding activities of the monoclonal antibody (mAb) portion of the molecule.https://www.creative-biolabs.com/adc/adc-affinity-measurement.htm

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Development of 5T4-based Bispecific ADCs A bispecific antibody can bind two different targets or two distinct epitopes on the same target. 5T4, specifically overexpressed on the cell surface of various tumors and internalized rapidly when bound to antibody, may be used as an attractive target to develop effective immunotherapy such as bispecific antibody-drug conjugate (ADC). https://www.creative-biolabs.com/adc/development-of-5t4-based-bispecific-adcs.htm

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✔ Clinical overviews (eCTD Module 2.5) including literature review and references ✔ Clinical summaries (eCTD Module 2.7) including clinical pharmacology, efficacy, and safety ✔ Clinical study report preparation and review (eCTD Module 5) ✔ Clinical justification documents for EU, US and other emerging Regulatory markets ✔ Gap analysis for dossiers in clinical module ✔ Clinical and nonclinical document support, handling queries during HA meetings and responding to them ✔ Technical review dossiers ✔ Biowaiver support and justification document services https://www.creative-biolabs.com/immuno-oncology/medical-writing-and-translation.htm

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Drug discovery and development pathway is a long journey, and complications and inefficiencies at the late stage can create costly delays. Therefore, safety and efficacy profiles assessments of drug candidates prior to clinical trials are critical stages to avoid unnecessary loss. Preclinical testing in animal models can help to foreseen potential risks of drug candidates before exposure to humans, and hence reduce the cost for pharmaceutical industries and help to make the appropriate choice.https://www.creative-biolabs.com/immuno-oncology/preclinical-testing.htm

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Drug stability studies are an important part of the drug development and life cycle, especially in support of development and IND submission activities. The stability test assesses how the quality of the drug substance or drug product or its packaging changes over time under the influence of environmental factors including temperature, humidity and light.https://www.creative-biolabs.com/immuno-oncology/stability-analysis.htm

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