This document discusses multiple myeloma and related plasma cell disorders including their typical age of onset, affected populations, mortality rate, pathogenesis involving certain proteins and molecular pathologies such as chromosomal deletions and translocations. Plasmacytoma, heavy chain disease, and primary amyloidosis are also mentioned.

2.  Multiple Myeloma
 Plasmacytoma
 Heavy Chain Disease
 Waldenstroms Macrogloblinemia
 Monoclonal Gammapathy Of Unsignificance
 Primary Amyloidosis

3.  50-60 yrs.
 Men
 1% death
Pathogenesis:
IL 6,-proliferation and survival of plasma cells
MIP1alpha and RANKL -osteolysis
Molecular pathology
Deletions of 13q,translocations on 14q32,
Derangements of cyclin D1 and D3.

12. Plasmacytoma

14. Heavy Chain Disesase

15. Primary Immunocyte Associated
Amyloidosis