The document discusses microcirculation and microcirculation microscopy. It describes how the AVACEN 100 device temporarily increases microcirculation through mild heat therapy. It then discusses nailfold capillary microscopy and how to observe capillaries under a microscope. Several aspects of microcirculation, nail growth, and capillary observation are examined.

1. microcirculation microscope and its parts is What?
microcirculation microscope and its parts is What?

2. [caption id="attachment_808" align="alignnone" width="630"]
nailfold capillary microscopy in scleroderm
a[/caption]
What is microcirculation microscope Overview
The AVACEN 100, Class-IIa, OTC medical device has been awarded the European Union CE (Conformité Européenne) Mark and is app
roved by Health Canada for the temporary increase of microcirculation.
AVACEN 100 U.S. FDA-Clearance: A heat therapy system indicated for the temporary relief of minor muscle and joint pain and stiffne
ss; the temporary relief of joint pain associated with arthritis; muscle spasms; minor strains and sprains; muscular relaxation; and th
e temporary increase of local circulation where applied.
NOTICE: The AVACEN 100 is not for sale in the U.S. for any FDA non-cleared indication mentioned in this document including MICROC
IRCULATION.
The AVACEN-100 uses the AVACEN Treatment Method to temporarily increase microcirculation to aid in the relief of minor muscle an
d joint pain and stiffness and the temporary relief of joint pain associated with conditions such as arthritis and fibromyalgia.
Getting your exercise and increasing your heart rate on a regular basis are obviously very good for your body.
One of the reasons increased circulation is so good for you has to do with a lesser talked about subject of naturally increased microci
rculation.
While circulation refers to blood flow to and from vital organs, microcirculation refers to blood flow in the smallest blood vessels in th
e body – capillaries, arterioles, and other such blood vessels. These blood vessels are often embedded in the organs, including the sk
in, and interact directly with muscle tissue.
Poor microcirculation is one of the single biggest contributing factors to almost all health problems: Diabetes, hypertension, vascular
disease, atherosclerosis, kidney disease, Alzheimer’s, early aging and others. It is estimated that 80% of the population over the age
of 40 may have moderately to extremely serious microcirculation problems and almost every non-injury related pain can be traced t
o a compromised microcirculation issue.
Until recently, there has never really been an increase in a body’s microcirculation without a proportionally larger increase in the bo
dy’s circulation. Meaning, you couldn’t really get the benefits of increased microcirculation without exercising, doing yoga, working o
ut, going in a sauna or jacuzzi, stretching, water aerobics, or other activities that might get the blood flowing.

3. Reading and you will quickly see why increased microcirculation just may be exactly what your body needs to reduce pain and swelli
ng on a daily basis.
[caption id="attachment_812" align="alignnone" width="731"]
nailfold capillary microscopy
scleroderma[/caption]

4. How to Installation and use the nailfold microcirculation microscope?
Insert the Monitor into the microscope.
Plug in 110Vto220 V power supply, and turn on the switch.
Spread a little fragrant pitch on the nail fold of the third finger on left hand and put it in the finger seat, adjust the vertical-horizon
tal platform to make the nail fold under the objective lens, use the structure of ascent and descent adjustment to adjust the focus un
til the image become clear.
Horizontally move the Light source to adjust the direction or angle of image on the monitor.
What is The distribution model diagram of nail fold capillaries:
nail plate
nail fold
Inframammillary venous plexus (deep layer)
Inframammillary venous plexus(superficial layer)
Capillary ansa
Flexible branch
Afferent branch
Efferent branch
Papilla
Perivascular spaces
Epiderm
Dermis
Hypodermic tissue
Small vein
Glomeriform arteriovenous shunt
Small artery
Inframammillary venous plexus
Thin vein
Thin artery
Arteriovenous shunt
What is Fingernail Growth and Microcirculation

5. Fingernails reach their peak growth in the second and third decades, with a slight decline thereafter. A possible reason, is decreased
blood flow and medical conditions that can affect it — like Raynaud’s phenomenon, which causes a spasmodic constriction of blood fl
ow.
As the nail receives nutrition from blood flow, new nail plate cells are made. They push older nail plate cells forward extending the le
ngth of the nail. In humans, nails grow at an average rate of 3 mm (0.12 in) a month.
Using the AVACEN 100 has been shown to increase projected fingernail growth by approximately 400% of normal expected growth o
n both the treatment hand and the opposite hand. This is attributed to the increased microvascular circulation and nutrition initiated
by the device.*
A 56 year old female was used in the pictures below. Only the left hand was used in the AVACEN 100 for a 6 day period. Using recog
nized nail growth calculations; the average age adjusted nail growth should be approximately 1/10th of an inch for an entire month .
The pictures below shows the nail growth on the right hand to be approximately 1/10th of an inch in only 6 days.
What is Microcirculation Capillary Observation
Introduction: The AVACEN 100 continues to warm the blood passing through the treatment palm, which then circulates throughout t
he entire body increasing core body temperature. When core body temperature rises, pre-capillary arterioles dilate causing normally
collapsed capillaries to open further improving microcirculation throughout the body. This allows excess heat to be dissipated by con
vection and radiation into the cooler ambient environment until the blood becomes cooler.

6. Hypothesis: If the AVACEN 100 is effecting the entire body, then distant capillaries from the AVACEN treatment hand should exhibit i
ncreased blood flow (microcirculation) after treatment.
Materials and Methods: A microcirculation microscope (Shenzhen GH Biotechnology Development Co. model 380, with Cargille imme
rsion oil type A), was used to observe capillary blood flow on the right hand ring finger in an area just below the finger nail (“Before”
figure). The left hand was then treated using the AVACEN 100 medical device to infuse heat into the circulatory system for 20 minut
es. Immediately following the AVACEN 100 treatment of the left hand, the same capillary area on the right hand was observed (“Afte
r” figure). To make sure the same capillaries were observed pre and post treatment, the finger was inserted into the stationary finge
r holder up to the point where a stop secured to the bottom side of the finger preventing further forward movement. All focusing and
platform adjusters remained in the identical setting.
Results: A significant increase in capillary blood flow in the right hand immediately after AVACEN 100 treatment of the left hand pal
m was observed.
What is Capillaroscopy ?
The capillaroscopy is a non-invasive technique at nailfold level, making it possible to assess the characteristics of the nailfold distal c
apillaries, thanks to a lens and a light that shines on said spot.
The information it provides us with helps to complete the diagnosis of the vasculitic autoimmune process of the patient; it does not p
ermit a diagnosis or specific therapeutic approach on its own.
For its correct visualisation, the patient is recommended:
Not to wear nail varnish and to avoid external harm (bumps, wounds, nail biting)
Not to smoke in the 2 hours prior to the test
To remain in the a room with a temperature of between 22ºC and 25ºC to avoid vasoconstriction episodes due to exogenous facto
rs.

7. WHAT ARE ITS USES?
The capillaroscopy allows us to know the extent of the distal vascularisation, which is very important in systemic sclerosis and other
connective pathologies, as well as to rule out systemic involvement in patients with Raynaud's phenomenon with no other associate
d clinical involvement.
RAYNAUD IS PHENOMENON
The capillaroscopy of the nail bed is a simple, bloodless, economical method which is very useful for studying Raynaud's phenomeno
n and other rheumatological conditions. Raynaud's phenomenon can be defined as the change in the colouring of the fingers and/or
toes in response to cold or stress. It traditionally progresses through three stages: paleness (vasospasm), cyanosis (due to increased
carboxyhemoglobin) and erythema (reactive hiperemia).
Raynaud's phenomenon can be primary (Raynaud's disease) or secondary, associated with a connective tissue disease. Primary Ray
naud's phenomenon is responsible for around 60% of all new cases. 15-20% of cases of Raynaud's phenomenon are due to a series
of non- immunological processes, such as drugs, occupational diseases, neoplasms, etc. The remaining 15-20% are associated with c
onnective tissue diseases.

8. Raynaud's is present in over 90% of patients with scleroderma and in 70% of cases it is the first symptom. Although it seems imposs
ible to predict that a patient with Raynaud's will develop scleroderma, the presence of antinuclear antibodies (ANA) indicates a great
er risk of onset.
SCLERODERMA
The nail bed capillaroscopy shows morphological alterations at an early stage in some connective tissue diseases of maximum rheu
matological interest, particularly capillaroscopy. In these cases, the capillaroscopy traditionally shows the "sclerodermic pattern" cha
racterised by: reduction or absence of capillaries in patches, capillary dilation, and sometimes mega-capillaries and splinter haemorr
hages. This "sclerodermic pattern" appears early and when it is observed in patients with Raynaud's phenomenon, even if it is not ve
ry obvious, it should lead to the search for sclerodermic manifestations in internal organs, which can be present without causing any
symptoms. The combination of Raynaud's phenomenon and a "sclerodermic pattern" in a capillaroscopy can precede and therefore
predict the onset of scleroderma.

10. CAPILLAROSCOPY AND RHEUMATOLOGICAL CONDITIONS
In dermatomyositis, the capillaroscopy is similar and sometimes indistinguishable from that found in scleroderma. These patients
generally present the other clinical, enzymatic or electromyographic manifestations of dermatomyositis that enable its recognition a
nd diagnosis.
In mixed connective tissue disease (MCTD) or overlap syndromes that a sclerodermic component, the findings of the capillaroscop
y can be similar although rarely are large capillary dilations and mega-capillaries observed. These capillaroscopies must be analysed
by an expert.
In systemic lupus erythematosus, the alterations in the capillaroscopy are non-specific, and it is possible to find focal capillary red
uction, albeit not very strong. The capillaries can be somewhat dilated and tortuous, sometimes with criss-crossing of the arterial an
d venous components (ringlets), the latter being the most characteristic finding in the capillaroscopy.
In primary Raynaud's phenomenon, the most striking characteristic is the elongated capillaries with undulations throughout the ar
terial and venous components. Little or no reduction or dilation of the capillaries can be observed. Splinter haemorrhages are scarce
and small.
Ultimately, this is an auxiliary diagnostic technique with great value in rheumatology and vascular disease.
Where and who need the nailfold microcirculation microscope?
The microcirculation microscope is widely used in the field of hospitals, school laboratories, clinics, etc., as the best auxiliary testing
equipment. And it is also used in health food industry, as a communication platform for product promotion when, making money equ
ipment, beauty industry.
For it is non-invasive, only to observe the end of the finger armor section, you can do the blood microcirculation review. You can obs
erve microcirculation pipe loop patterns, the number of pipe loop, blood flow, bleeding, etc., help determine the sub-health status an
d blood stasis and brain / cardiovascular related diseases.
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11. [caption id="attachment_848" align="alignnone" width="730"]
microcirculation microscope
and its parts[/caption][caption id="attachment_849" align="alignnone" width="731"]
microcirculation microscope
and its parts[/caption]