MEASURING HEALTH RELATED QUALITY OF LIFE IN DIABETES: THE VALIDATION OF THE DIABETES HEALTH PROFILE (DHP-18) AND THE DEVELOPMENT OF A BRIEF MEASURE OF DIABETES RELATED HRQL (DHP-12)
This study aimed to validate the Diabetes Health Profile (DHP-18), a patient-reported outcome measure with three domains (psychological distress, barriers to activity, disinhibited eating), and develop a shorter 12-item version (DHP-12). Factor and Rasch analyses were conducted on data from over 1,500 patients to validate the domain structure and assess item performance. Based on these analyses, four items were selected from each domain to create the DHP-12. Initial comparisons found the DHP-12 scores were highly correlated with the DHP-18 and had comparable psychometric properties, though the barriers to activity domain showed lower internal consistency.
Exploring LIS practitioner engagement with research: lessons from a UK case s...ScHARR HEDS
More Related Content
Similar to MEASURING HEALTH RELATED QUALITY OF LIFE IN DIABETES: THE VALIDATION OF THE DIABETES HEALTH PROFILE (DHP-18) AND THE DEVELOPMENT OF A BRIEF MEASURE OF DIABETES RELATED HRQL (DHP-12)
Similar to MEASURING HEALTH RELATED QUALITY OF LIFE IN DIABETES: THE VALIDATION OF THE DIABETES HEALTH PROFILE (DHP-18) AND THE DEVELOPMENT OF A BRIEF MEASURE OF DIABETES RELATED HRQL (DHP-12) (20)
VIP Call Girls Noida Jhanvi 9711199171 Best VIP Call Girls Near Me
MEASURING HEALTH RELATED QUALITY OF LIFE IN DIABETES: THE VALIDATION OF THE DIABETES HEALTH PROFILE (DHP-18) AND THE DEVELOPMENT OF A BRIEF MEASURE OF DIABETES RELATED HRQL (DHP-12)
1. There is a need to validate existing patient reported outcome measures (PROMS) to
provide evidence on their validity. Subsequently, short measures can be developed from
validated PROMS to lessen respondent burden. The aim of this study was to:
•Validate the three domain conceptual framework of the Diabetes Health Profile (DHP-18)
•Apply Rasch analysis to investigate the performance of the DHP-18 and develop a short
12 item version (DHP-12).
Introduction
MEASURING HEALTH RELATED QUALITY OF LIFE IN DIABETES:
THE VALIDATION OF THE DIABETES HEALTH PROFILE (DHP-18) AND THE DEVELOPMENT
OF A BRIEF MEASURE OF DIABETES RELATED HRQL (DHP-12)
Brendan Mulhern1
& Keith Meadows2
1
Health Economics and Decision Science, University of Sheffield; 2 DHP Research and Consultancy Ltd
The DHP-18 (Meadows et al., 2000):
•Assesses psychosocial functioning in Type 2 diabetes across three domains:
Psychological Distress; Barriers to Activity; Disinhibited Eating (scored on a 0-100 scale)
•Is the diabetes-specific outcome measure selected for the UK Department of Health
Patient Reported Outcome Measures Pilot for Long Term Conditions in Primary Care.
The Diabetes Health Profile (www.diabeteshealthprofile.com)
DHP-18 validation:
•Exploratory factor analysis was used to investigate the factor structure of the DHP-18
Rasch analysis:
•Rasch analysis was used to investigate the performance of the DHP-18 and select items
for the DHP-12. Rasch assesses the performance of individual items in relation to the
underlying trait measured by the dimension level model.
•Rasch assesses:
•The ordering of item response categories (disordered items are rescored )
•Differential item functioning (DIF) across different background characteristics
•The fit of each item to the overall model
•The position of each item on the underlying severity (latent) scale (negative
values cover the severe end of the scale, zero is the average, positive values
cover the mild end of the scale
Rasch was applied to each of the DHP-18 dimensions across two data subsets
DHP-18/DHP-12 comparison:
•The correlations between the measures were assessed
•Internal consistency for each domain was assessed using Cronbach’s alpha
•A separate comparison sample was used for this analysis
Sample:
Methods
Facto r and Ras ch analys is (DHP-1 2 ite m s hig hlig hte d in g re e n)
DHP-1 2
•Four items from each domain have been selected.
•Responses to 10 items are disordered so have been rescored (raw score range is 0-26).
•One item (depression due to diabetes) displays DIF by gender. This item has been retained
as depression in diabetes has been found to be higher in females (Lustman et al, 1988).
DHP-1 8 /DHP-1 2 co m paris o n:
Results
•The three domain structure of the Diabetes Health Profile was confirmed.
•Rasch analysis indicates that the DHP-18 has satisfactory performance overall. This means
that the measure provides a valid basis for the development of a new short diabetes specific
PROM.
•A variety of Rasch analysis criteria have been used to develop a12 item version of the
Diabetes Health Profile (DHP-12) that includes four items in each domain.
•Initial psychometric analysis demonstrates evidence for the comparability of the DHP-12 and
DHP-18, but the internal consistency of the Barriers to Activity domain is low. Further analysis
Discussion
Factor and Rasch analysis Comparison sample
S1: Development S2: Validation
n 771 810 2953
Aged above 65 57.6% 57.9% 52.42%
Gender Male 59.4% 62.2% 53.90%
DHP-18 scores
Psychological Distress 19.07 18.21 19.26
Barriers to Activity 22.33 21.11 23.30
Factor loading Rasch analysis
Item Ordered? No DIF? Fit? Location DHP-12? Scoring
PD BA DE 1 2 1 2 1 2 1 2
Psychological distress domain
6. Lose temper if people nag 0.54 √ √ n/a n/a n/a
15. Lose temper or shout due to diabetes 0.86 √ √ n/a n/a n/a
14. Depression due to diabetes 0.62 √ √ -0.96 -0.73 √ 0-2
16. Lose temper over small things 0.8 √ √ √ √ √ -0.52 -0.19 √ 0-2
17. Moody about diabetes 0.69 √ √ √ √ √ 0.5 0.14 √ 0-2
18. More arguments at due to diabetes 0.68 √ √ √ √ √ 0.97 0.79 √ 0-2
Barriers to activity domain
2. Difficult staying out late 0.62 √ √ √ n/a n/a n/a
3. Days tied to meal times 0.72 √ √ √ √ n/a n/a n/a
12. Worry about busy shops 0.44 √ √ n/a n/a n/a
1. Food control life 0.47 √ √ √ √ √ -0.96 -1.03 √ 0-2
4. Avoid going out if sugars low 0.63 √ √ √ √ 0.24 0.16 √ 0-2
10. Worry about colds/flu 0.44 √ √ √ √ -0.07 0.02 √ 0-2
13. Edgy when out and nowhere to eat 0.56 √ √ √ √ 0.26 0.26 √ 0-2
Disinhibited eating domain
11. Wish not so many nice things to eat 0.5
0 √ √ √
n/a n/a n/a
5. Eat to cheer yourself up 0.7
7 √ √ √
√ √ 0.87 0.35 √ 0-2
7. Hard to say no to food you like 0.7
5 √ √ √
√ √ -0.04 0.08 √ 0-2
8. Easy to stop eating 0.6
3 √ √ √ √
√ √ 0.33 0.57 √ 0-3
9. Eat extra when bored/fed up 0.6
7 √ √ √ √
√ √ -1.61 -1.00 √ 0-3
Mean (sd) Range Correlation % floor % ceiling Alpha
PD factor 0.95
DHP-18 19.26 (18.69) 0-100 17.6 0.2 0.83
DHP-12 27.19 (23.93) 0-100 20.3 1.2 0.76
BA factor 0.86
DHP-18 23.30 (17.94) 0-100 8.8 0.1 0.68
DHP-12 24.68 (18.68) 0-100 16.1 0.1 0.48
DE factor 0.96
DHP-18 33.45 (23.85) 0-100 10.3 1.0 0.76
DHP-12 38.11 (26.90) 0-100 14.5 2.3 0.71