The document compares the MEAN and MERN stacks, highlighting their advantages for web and mobile application development, with MEAN being recognized for its open-source capabilities and minimal development costs, while MERN excels in user interface development and security features. It also discusses developer preferences, noting that businesses often lean towards MERN due to the versatility of React developers. Ultimately, it emphasizes the importance of selecting the right stack based on the specific needs for functionality, security, and development experience.