The document outlines the mission, management team, board of directors, and marketing solutions of an organization called Entrepinoy MPC. Its mission is to help Filipinos achieve economic independence through business opportunities. It provides a financial assistance program and cash incentive program to help members start businesses. The program utilizes a multi-level structure where members can earn unilevel income from recruiting others and benefits increase as more levels are added to their network.
ENTREPINOY MULTI-PURPOSE COOPERATIVE
Creating trends in cooperative in the Philippines.
Guaranteed 100% loan Approval....Offering zero interest, No Collateral, No Co-maker, No CI & NO PDC,livelihood & Cash Assistance Programs.
Join us!
The document describes a cooperative marketing company that aims to help Filipinos achieve financial independence through business opportunities and loan assistance programs. It provides entrepreneurial training and business kits to members. The company's management team is led by an experienced board of directors. It offers a loan program through a multi-level cash incentive and product sales program that provides rebates, cash rewards, and bonuses to members as their business networks grow. The goal is to create a sustainable cycle of business and cooperative income sharing.
This document summarizes an opportunity plan seminar that provides insurance benefits and cash bonuses or assistance to members. It outlines 17 types of bonuses earned through recruitment including weekly unlimited P500 bonuses and bonuses from P20,000 to P1,000,000 for recruiting multiple members. It also details medical funds, reimbursements, and cash assistance programs that require a certain number of recruits to qualify for loans from P5,000 to P100,000. Overall, the document promotes joining the opportunity plan for insurance coverage and the ability to earn bonuses and cash through recruiting others.
This document outlines the marketing plan and income opportunities for eSky2u.com. There are starter packages priced from $20-100 that provide various benefits and bonuses. The income plan includes fast start bonuses, daily pairing bonuses, and leadership matching bonuses calculated based on package purchases and referrals. The plan also details maintenance product packages, qualification criteria for different bonus levels, and stockist franchise programs for mobile and city top up centers.
The document outlines the mission, management team, board of directors, and marketing solutions of an organization called Entrepinoy MPC. Its mission is to help Filipinos achieve economic independence through business opportunities. It provides a financial assistance program and cash incentive program to help members start businesses. The program utilizes a multi-level structure where members can earn unilevel income from recruiting others and benefits increase as more levels are added to their network.
ENTREPINOY MULTI-PURPOSE COOPERATIVE
Creating trends in cooperative in the Philippines.
Guaranteed 100% loan Approval....Offering zero interest, No Collateral, No Co-maker, No CI & NO PDC,livelihood & Cash Assistance Programs.
Join us!
The document describes a cooperative marketing company that aims to help Filipinos achieve financial independence through business opportunities and loan assistance programs. It provides entrepreneurial training and business kits to members. The company's management team is led by an experienced board of directors. It offers a loan program through a multi-level cash incentive and product sales program that provides rebates, cash rewards, and bonuses to members as their business networks grow. The goal is to create a sustainable cycle of business and cooperative income sharing.
This document summarizes an opportunity plan seminar that provides insurance benefits and cash bonuses or assistance to members. It outlines 17 types of bonuses earned through recruitment including weekly unlimited P500 bonuses and bonuses from P20,000 to P1,000,000 for recruiting multiple members. It also details medical funds, reimbursements, and cash assistance programs that require a certain number of recruits to qualify for loans from P5,000 to P100,000. Overall, the document promotes joining the opportunity plan for insurance coverage and the ability to earn bonuses and cash through recruiting others.
This document outlines the marketing plan and income opportunities for eSky2u.com. There are starter packages priced from $20-100 that provide various benefits and bonuses. The income plan includes fast start bonuses, daily pairing bonuses, and leadership matching bonuses calculated based on package purchases and referrals. The plan also details maintenance product packages, qualification criteria for different bonus levels, and stockist franchise programs for mobile and city top up centers.
Parallel mechanisms of epigenetic reprogramming in the germlineLoki Stormbringer
Germ cells possess the extraordinary and unique capacity to give rise to a new organism and create an enduring link between all generations. To acquire this property, primordial germ cells (PGCs) transit through an unprecedented programme of sequential epigenetic events that culminates in an epigenomic basal state that is the foundation of totipotency. This process is underpinned by genome-wide DNA demethylation, which may occur through several overlapping pathways, including conversion to 5-hydroxymethylcytosine. We propose that the epigenetic programme in PGCs operates through multiple parallel mechanisms to ensure robustness at the level of individual cells while also being flexible through functional redundancy to guarantee high fidelity of the process. Gaining a better understanding of the molecular mechanisms that direct epigenetic reprogramming in PGCs will enhance our ability to manipulate epigenetic memory, cell-fate decisions and applications in regenerative medicine.
Metabolic depression in hibernation and major depression: an explanatory theo...Loki Stormbringer
1) The document proposes that metabolic depression, an adaptive process of energy preservation seen in hibernation, is responsible for major depression in humans.
2) It suggests bears are a good animal model for studying depression because they hibernate with only mild hypothermia, unlike other hibernating animals.
3) Many similarities are seen between hibernation in bears and major depression in humans, including neurobiological changes, symptoms, and the underlying metabolic processes. This supports the theory that metabolic depression underlies both.
A presentation given to PSCP executive committee providing an overview of the 4 major social media sites (facebook, Google+, LinkedIn and Twitter) and describing next steps in an adoption.
This document contains an agenda for a SQL Saturday session on .NET fundamentals by Mike Huguet. The session will cover generics, extension methods, lambda expressions, and LINQ. It will introduce these concepts and enhance attendees' knowledge of them. The document provides definitions and examples of each concept. It also outlines the timeline of when they were introduced in the .NET framework and how they can increase developer productivity.
CTC1 deletion results in defective telomere replication, leading to catastrop...Loki Stormbringer
The proper maintenance of telomeres is essential for genome stability. Mammalian telomere maintenance is governed by a number of telomere binding proteins, including the newly identified CTC1–STN1–TEN1 (CST) complex. However, the in vivo functions of mammalian CST remain unclear. To address this question, we conditionally deleted CTC1 from mice. We report here that CTC1 null mice experience rapid onset of global cellular proliferative defects and die prematurely from complete bone marrow failure due to the activation of an ATR-dependent G2/M checkpoint. Acute deletion of CTC1 does not result in telomere deprotection, suggesting that mammalian CST is not involved in capping telomeres. Rather, CTC1 facilitates telomere replication by promoting efficient restart of stalled replication forks. CTC1 deletion results in increased loss of leading C-strand telomeres, catastrophic telomere loss and accumulation of excessive ss telomere DNA. Our data demonstrate an essential role for CTC1 in promoting efficient replication and length maintenance of telomeres.
Mechanisms of white matter changes induced by meditationLoki Stormbringer
Using diffusion tensor imaging, several recent studies have shown that training results in changes in white matter efficiency as measured by fractional anisotropy (FA). In our work, we found that a form of mindfulness meditation, integrative body–mind training (IBMT), improved FA in areas surrounding the anterior cingulate cortex after 4-wk training more than controls given relaxation training. Reductions in radial diffusivity (RD) have been interpreted as improved myelin but reductions in axial diffusivity (AD) involve other mechanisms, such as axonal density. We now report that after 4-wk training with IBMT, both RD and AD decrease accompanied by increased FA, indicating improved efficiency of white matter involves increased myelin as well as other axonal changes. However, 2-wk IBMT reduced AD, but not RD or FA, and improved moods. Our results demonstrate the time-course of white matter neuroplasticity in short-term meditation. This dynamic pattern of white matter change involving the anterior cingulate cortex, a part of the brain network related to self-regulation, could provide a means for intervention to improve or prevent mental disorders.
Meta analysis of genome-wide association studies for personalityLoki Stormbringer
Personality can be thought of as a set of characteristics that influence people’s thoughts,
feelings and behavior across a variety of settings. Variation in personality is predictive of many
outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide
association (GWA) data for personality in 10 discovery samples (17 375 adults) and five
in silico replication samples (3294 adults).
This document provides strategies for effectively handling difficult conversations and arguments. It recommends softening nonverbal communication, maintaining objectivity, controlling the environment, and preventing escalation to resolve conflicts without directly engaging or being cornered. Historical quotes are referenced to emphasize the value of preventative measures over corrective actions once a situation has intensified.
Anatomical plasticity of adult brain is titrated by nogo receptor 1 (06 March...Loki Stormbringer
Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1−/− mice. Adolescent anatomical plasticity can be restored to 1-year-old mice by conditional deletion of ngr1. Suppression of anatomical dynamics by NgR1 is cell autonomous and is phenocopied by deletion of Nogo-A ligand. Whisker removal deprives the somatosensory cortex of experience-dependent input and reduces dendritic spine turnover in adult ngr1−/− mice to control levels, while an acutely enriched environment increases dendritic spine dynamics in control mice to the level of ngr1−/− mice in a standard environment. Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex.
Appeal from the united states district court for the eastern district of wisc...Loki Stormbringer
This is a case about how a court may dispose of a copyright infringement action based on the fair use affirmative defense while avoiding the burdens of discovery and trial. This case also poses the interesting question of whether the incorporation-byreference doctrine applies to audio-visual works.
"We noted during oral argument that such a broad discovery request, surely entailing expensive e-discovery of emails or other internal communications, gives Brownmark the appearance of a “copyright troll.” We are confident that the district court would have refused to grant such expansive demands."
Matrix rigidity controls endothelial differentiation and morphogenesis of car...Loki Stormbringer
Tissue development and regeneration involve tightly coordinated and integrated processes: selective proliferation of resident stem and precursor cells, differentiation into target somatic cell type, and spatial morphological organization. The role of the mechanical environment in the coordination of these processes is poorly understood. We show that multipotent cells derived from native cardiac tissue continually monitored cell substratum rigidity and showed enhanced proliferation, endothelial differentiation, and morphogenesis when the cell substratum rigidity closely matched that of myocardium. Mechanoregulation of these diverse processes required p190RhoGAP, a guanosine triphosphatase–activating protein for RhoA, acting through RhoA-dependent and -independent mechanisms. Natural or induced decreases in the abundance of p190RhoGAP triggered a series of developmental events by coupling cell-cell and cell-substratum interactions to genetic circuits controlling differentiation.
It is unclear where plate boundary thrusts generate giant rather than great earthquakes. Along the Himalayas, the source
sizes and recurrence times of large seismic events are particularly uncertain, since no surface signatures were found for those
that shook the range in the twentieth century. Here we challenge the consensus that these events remained blind and did not
rupture the surface.We use geomorphological mapping of fluvial deposits, palaeo-seismological logging of river-cut cliffs and
trench walls, and modelling of calibrated 14C ages, to show that the Mw 8.2 Bihar–Nepal earthquake on 15 January 1934 did
break the surface: traces of the rupture are clear along at least 150 km of the Main Frontal Thrust fault in Nepal, between
85 500 and 87 200 E. Furthermore, we date collapse wedges in the Sir Valley and find that the 7 June AD 1255 earthquake,
an event that devastated Kathmandu and mortally wounded the Nepalese King Abhaya Malla, also ruptured the surface along
this stretch of the mega-thrust. Thus, in the past 1,000 years, two great earthquakes, 679 years apart, rather than one giant
eleventh-century AD event, contributed to the frontal uplift of young river terraces in eastern Nepal. The rare surface expression
of these earthquakes implies that surface ruptures of other reputedly blind great Himalayan events might exist.
Metal protein attenuating compounds for the treatment of alzheimer's dementiaLoki Stormbringer
The protein amyloid-β (Aß) is strongly implicated in the development of Alzheimer's dementia, where it aggregates in clumps causing damage and death of brain cells. This clumping is encouraged by copper and zinc (metal ions) in the brain. Metal protein attenuating compounds (MPACS) bind strongly to copper and zinc (this is known as chelation), both preventing the clumping together of Aß and promoting processes which may cause it to dissolve and so be cleared from brain cells. Therefore MPACS may be a potential therapy for Alzheimer's dementia. Two different types of MPAC have been used in clinical trials and the drugs are known as PBT1 and PBT2. The trial of PBT1 compared with placebo (in 36 patients) showed no statistically significant difference in cognition or memory between the active treatment and placebo groups at 36 weeks. We therefore conclude that there is no current evidence that treatment with clioquinol (PBT1) has any significant effect on cognition and in particular memory (as measured by the ADAS-Cog scale) in patients with Alzheimer's dementia. This drug has now been withdrawn from development. The trial of PBT2 showed it was safe after 12 weeks of treatment but demonstrated no overall significant effect on cognition or memory.
The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and ...Loki Stormbringer
For some, glioma biomarkers have been expected to solve common diagnostic problems in routine neuropathology service caused by insufficient material, technical shortcomings or lack of experience. Further, biomarkers should predict patient outcome and direct optimal therapy for the individual patient. Unfortunately, current biomarkers still fall somewhat short of these grand expectations. While there has been some progress, it has generally been slow and in small steps. In this review, the newest set of glioma biomarkers: O(6) -methylguanine-DNA methyltransferase (MGMT) methylation, BRAF fusion and IDH1 mutation are discussed. MGMT methylation is well established as a prognostic/predictive marker for glioblastoma; however, technical questions regarding testing remain, it is not currently utilized widely in guiding patient management, and it has proven to be of no assistance in diagnostics. In contrast, BRAF fusion and IDH1 mutation analyses promise to be very helpful for classifying and grading gliomas, while their potential predictive value has yet to be established.
Interventions to Improve Cognitive Functioning After TBILoki Stormbringer
This document discusses interventions to improve cognitive functioning after traumatic brain injury (TBI). It begins by introducing a case study of a veteran experiencing cognitive issues after multiple blast exposures during deployment. It then provides an overview of TBI, noting that while injuries are acute, cognitive deficits can persist chronically and impact individuals, families, and society. It discusses the importance of recognizing and treating chronic cognitive dysfunction, and how a combination of physical and psychological trauma from combat experiences could result in a complex "combined combat neurotrauma syndrome." The document advocates considering multiple levels of brain functioning and integrating behavioral and pharmacological therapies to effectively improve post-TBI cognitive functioning.
DGAINS Group is a global enterprise with diversified business interests including IT solutions, engineering, imports/exports, trading, marketing and direct selling. One of its divisions is D Health N Fame & D-ZONE International, which operates the DHNF business. DHNF sells 100% natural and organic personal care products through a direct selling model. Distributors can purchase products at a distributor price to use personally and resell, earning instant retail profit. The business plan includes income from building a binary team, spillover placements, consultancy income, and generation team bonuses based on group turnover points. Higher ranks provide additional rewards like cars and advisory roles. The goal is to share health, wealth, fun and fame globally through
This document introduces a new multi-level marketing business system called Speedy Independent Distributor (SID). It has various business packages including MyStarter, MyPrivilege, and MyBinary that provide different income benefits through retail profit, bonuses, and leadership bonuses. It also has retirement, speedy rider, and rewards plans that generate long term residual income. Individuals can become customers, mobile stockists, business centers, or SIDs. The marketing plan incentivizes recruitment through direct sponsor bonuses, repeat purchase bonuses, and a binary compensation structure.
This document summarizes the packages, bonuses, and benefits offered by Powerline. The Powerline Package costs 1,250 pesos and includes SIMONE products, an ATM card, and online back office access. Members can earn a daily profit share bonus of up to 1,500 pesos by having two direct recruits. Additional bonuses are offered for leadership, recruiting six members within seven days, and recruiting 50 members within 30 or 60 days to qualify for a new car. The Damayan program provides 10 pesos per active member to assist those experiencing grief.
This document summarizes the compensation plan and product offering for a multi-level marketing company called Yoli. It describes 9 ways for distributors to earn money, including retail profits, bonuses for starting and maintaining an autoship order each month. It also outlines a unilevel matching bonus plan with up to 10 levels, as well as global bonus pools and leadership bonuses. The company's flagship product called Alkatele is described as helping remove acid waste and support healthy pH levels.
This document provides information about a company that offers video-based communication products and services. It was founded in 2002 and is debt-free with a global market presence. The company's flagship products allow users to send video emails with pre-designed templates and video resumes and web conferences. It also offers live broadcasting and video file sharing capabilities. The business opportunity allows individuals to earn commissions from a binary compensation plan by building two teams and achieving a 4:2 ratio. Payouts can reach $5,000 per day at higher levels.
Parallel mechanisms of epigenetic reprogramming in the germlineLoki Stormbringer
Germ cells possess the extraordinary and unique capacity to give rise to a new organism and create an enduring link between all generations. To acquire this property, primordial germ cells (PGCs) transit through an unprecedented programme of sequential epigenetic events that culminates in an epigenomic basal state that is the foundation of totipotency. This process is underpinned by genome-wide DNA demethylation, which may occur through several overlapping pathways, including conversion to 5-hydroxymethylcytosine. We propose that the epigenetic programme in PGCs operates through multiple parallel mechanisms to ensure robustness at the level of individual cells while also being flexible through functional redundancy to guarantee high fidelity of the process. Gaining a better understanding of the molecular mechanisms that direct epigenetic reprogramming in PGCs will enhance our ability to manipulate epigenetic memory, cell-fate decisions and applications in regenerative medicine.
Metabolic depression in hibernation and major depression: an explanatory theo...Loki Stormbringer
1) The document proposes that metabolic depression, an adaptive process of energy preservation seen in hibernation, is responsible for major depression in humans.
2) It suggests bears are a good animal model for studying depression because they hibernate with only mild hypothermia, unlike other hibernating animals.
3) Many similarities are seen between hibernation in bears and major depression in humans, including neurobiological changes, symptoms, and the underlying metabolic processes. This supports the theory that metabolic depression underlies both.
A presentation given to PSCP executive committee providing an overview of the 4 major social media sites (facebook, Google+, LinkedIn and Twitter) and describing next steps in an adoption.
This document contains an agenda for a SQL Saturday session on .NET fundamentals by Mike Huguet. The session will cover generics, extension methods, lambda expressions, and LINQ. It will introduce these concepts and enhance attendees' knowledge of them. The document provides definitions and examples of each concept. It also outlines the timeline of when they were introduced in the .NET framework and how they can increase developer productivity.
CTC1 deletion results in defective telomere replication, leading to catastrop...Loki Stormbringer
The proper maintenance of telomeres is essential for genome stability. Mammalian telomere maintenance is governed by a number of telomere binding proteins, including the newly identified CTC1–STN1–TEN1 (CST) complex. However, the in vivo functions of mammalian CST remain unclear. To address this question, we conditionally deleted CTC1 from mice. We report here that CTC1 null mice experience rapid onset of global cellular proliferative defects and die prematurely from complete bone marrow failure due to the activation of an ATR-dependent G2/M checkpoint. Acute deletion of CTC1 does not result in telomere deprotection, suggesting that mammalian CST is not involved in capping telomeres. Rather, CTC1 facilitates telomere replication by promoting efficient restart of stalled replication forks. CTC1 deletion results in increased loss of leading C-strand telomeres, catastrophic telomere loss and accumulation of excessive ss telomere DNA. Our data demonstrate an essential role for CTC1 in promoting efficient replication and length maintenance of telomeres.
Mechanisms of white matter changes induced by meditationLoki Stormbringer
Using diffusion tensor imaging, several recent studies have shown that training results in changes in white matter efficiency as measured by fractional anisotropy (FA). In our work, we found that a form of mindfulness meditation, integrative body–mind training (IBMT), improved FA in areas surrounding the anterior cingulate cortex after 4-wk training more than controls given relaxation training. Reductions in radial diffusivity (RD) have been interpreted as improved myelin but reductions in axial diffusivity (AD) involve other mechanisms, such as axonal density. We now report that after 4-wk training with IBMT, both RD and AD decrease accompanied by increased FA, indicating improved efficiency of white matter involves increased myelin as well as other axonal changes. However, 2-wk IBMT reduced AD, but not RD or FA, and improved moods. Our results demonstrate the time-course of white matter neuroplasticity in short-term meditation. This dynamic pattern of white matter change involving the anterior cingulate cortex, a part of the brain network related to self-regulation, could provide a means for intervention to improve or prevent mental disorders.
Meta analysis of genome-wide association studies for personalityLoki Stormbringer
Personality can be thought of as a set of characteristics that influence people’s thoughts,
feelings and behavior across a variety of settings. Variation in personality is predictive of many
outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide
association (GWA) data for personality in 10 discovery samples (17 375 adults) and five
in silico replication samples (3294 adults).
This document provides strategies for effectively handling difficult conversations and arguments. It recommends softening nonverbal communication, maintaining objectivity, controlling the environment, and preventing escalation to resolve conflicts without directly engaging or being cornered. Historical quotes are referenced to emphasize the value of preventative measures over corrective actions once a situation has intensified.
Anatomical plasticity of adult brain is titrated by nogo receptor 1 (06 March...Loki Stormbringer
Experience rearranges anatomical connectivity in the brain, but such plasticity is suppressed in adulthood. We examined the turnover of dendritic spines and axonal varicosities in the somatosensory cortex of mice lacking Nogo Receptor 1 (NgR1). Through adolescence, the anatomy and plasticity of ngr1 null mice are indistinguishable from control, but suppression of turnover after age 26 days fails to occur in ngr1−/− mice. Adolescent anatomical plasticity can be restored to 1-year-old mice by conditional deletion of ngr1. Suppression of anatomical dynamics by NgR1 is cell autonomous and is phenocopied by deletion of Nogo-A ligand. Whisker removal deprives the somatosensory cortex of experience-dependent input and reduces dendritic spine turnover in adult ngr1−/− mice to control levels, while an acutely enriched environment increases dendritic spine dynamics in control mice to the level of ngr1−/− mice in a standard environment. Thus, NgR1 determines the low set point for synaptic turnover in adult cerebral cortex.
Appeal from the united states district court for the eastern district of wisc...Loki Stormbringer
This is a case about how a court may dispose of a copyright infringement action based on the fair use affirmative defense while avoiding the burdens of discovery and trial. This case also poses the interesting question of whether the incorporation-byreference doctrine applies to audio-visual works.
"We noted during oral argument that such a broad discovery request, surely entailing expensive e-discovery of emails or other internal communications, gives Brownmark the appearance of a “copyright troll.” We are confident that the district court would have refused to grant such expansive demands."
Matrix rigidity controls endothelial differentiation and morphogenesis of car...Loki Stormbringer
Tissue development and regeneration involve tightly coordinated and integrated processes: selective proliferation of resident stem and precursor cells, differentiation into target somatic cell type, and spatial morphological organization. The role of the mechanical environment in the coordination of these processes is poorly understood. We show that multipotent cells derived from native cardiac tissue continually monitored cell substratum rigidity and showed enhanced proliferation, endothelial differentiation, and morphogenesis when the cell substratum rigidity closely matched that of myocardium. Mechanoregulation of these diverse processes required p190RhoGAP, a guanosine triphosphatase–activating protein for RhoA, acting through RhoA-dependent and -independent mechanisms. Natural or induced decreases in the abundance of p190RhoGAP triggered a series of developmental events by coupling cell-cell and cell-substratum interactions to genetic circuits controlling differentiation.
It is unclear where plate boundary thrusts generate giant rather than great earthquakes. Along the Himalayas, the source
sizes and recurrence times of large seismic events are particularly uncertain, since no surface signatures were found for those
that shook the range in the twentieth century. Here we challenge the consensus that these events remained blind and did not
rupture the surface.We use geomorphological mapping of fluvial deposits, palaeo-seismological logging of river-cut cliffs and
trench walls, and modelling of calibrated 14C ages, to show that the Mw 8.2 Bihar–Nepal earthquake on 15 January 1934 did
break the surface: traces of the rupture are clear along at least 150 km of the Main Frontal Thrust fault in Nepal, between
85 500 and 87 200 E. Furthermore, we date collapse wedges in the Sir Valley and find that the 7 June AD 1255 earthquake,
an event that devastated Kathmandu and mortally wounded the Nepalese King Abhaya Malla, also ruptured the surface along
this stretch of the mega-thrust. Thus, in the past 1,000 years, two great earthquakes, 679 years apart, rather than one giant
eleventh-century AD event, contributed to the frontal uplift of young river terraces in eastern Nepal. The rare surface expression
of these earthquakes implies that surface ruptures of other reputedly blind great Himalayan events might exist.
Metal protein attenuating compounds for the treatment of alzheimer's dementiaLoki Stormbringer
The protein amyloid-β (Aß) is strongly implicated in the development of Alzheimer's dementia, where it aggregates in clumps causing damage and death of brain cells. This clumping is encouraged by copper and zinc (metal ions) in the brain. Metal protein attenuating compounds (MPACS) bind strongly to copper and zinc (this is known as chelation), both preventing the clumping together of Aß and promoting processes which may cause it to dissolve and so be cleared from brain cells. Therefore MPACS may be a potential therapy for Alzheimer's dementia. Two different types of MPAC have been used in clinical trials and the drugs are known as PBT1 and PBT2. The trial of PBT1 compared with placebo (in 36 patients) showed no statistically significant difference in cognition or memory between the active treatment and placebo groups at 36 weeks. We therefore conclude that there is no current evidence that treatment with clioquinol (PBT1) has any significant effect on cognition and in particular memory (as measured by the ADAS-Cog scale) in patients with Alzheimer's dementia. This drug has now been withdrawn from development. The trial of PBT2 showed it was safe after 12 weeks of treatment but demonstrated no overall significant effect on cognition or memory.
The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and ...Loki Stormbringer
For some, glioma biomarkers have been expected to solve common diagnostic problems in routine neuropathology service caused by insufficient material, technical shortcomings or lack of experience. Further, biomarkers should predict patient outcome and direct optimal therapy for the individual patient. Unfortunately, current biomarkers still fall somewhat short of these grand expectations. While there has been some progress, it has generally been slow and in small steps. In this review, the newest set of glioma biomarkers: O(6) -methylguanine-DNA methyltransferase (MGMT) methylation, BRAF fusion and IDH1 mutation are discussed. MGMT methylation is well established as a prognostic/predictive marker for glioblastoma; however, technical questions regarding testing remain, it is not currently utilized widely in guiding patient management, and it has proven to be of no assistance in diagnostics. In contrast, BRAF fusion and IDH1 mutation analyses promise to be very helpful for classifying and grading gliomas, while their potential predictive value has yet to be established.
Interventions to Improve Cognitive Functioning After TBILoki Stormbringer
This document discusses interventions to improve cognitive functioning after traumatic brain injury (TBI). It begins by introducing a case study of a veteran experiencing cognitive issues after multiple blast exposures during deployment. It then provides an overview of TBI, noting that while injuries are acute, cognitive deficits can persist chronically and impact individuals, families, and society. It discusses the importance of recognizing and treating chronic cognitive dysfunction, and how a combination of physical and psychological trauma from combat experiences could result in a complex "combined combat neurotrauma syndrome." The document advocates considering multiple levels of brain functioning and integrating behavioral and pharmacological therapies to effectively improve post-TBI cognitive functioning.
DGAINS Group is a global enterprise with diversified business interests including IT solutions, engineering, imports/exports, trading, marketing and direct selling. One of its divisions is D Health N Fame & D-ZONE International, which operates the DHNF business. DHNF sells 100% natural and organic personal care products through a direct selling model. Distributors can purchase products at a distributor price to use personally and resell, earning instant retail profit. The business plan includes income from building a binary team, spillover placements, consultancy income, and generation team bonuses based on group turnover points. Higher ranks provide additional rewards like cars and advisory roles. The goal is to share health, wealth, fun and fame globally through
This document introduces a new multi-level marketing business system called Speedy Independent Distributor (SID). It has various business packages including MyStarter, MyPrivilege, and MyBinary that provide different income benefits through retail profit, bonuses, and leadership bonuses. It also has retirement, speedy rider, and rewards plans that generate long term residual income. Individuals can become customers, mobile stockists, business centers, or SIDs. The marketing plan incentivizes recruitment through direct sponsor bonuses, repeat purchase bonuses, and a binary compensation structure.
This document summarizes the packages, bonuses, and benefits offered by Powerline. The Powerline Package costs 1,250 pesos and includes SIMONE products, an ATM card, and online back office access. Members can earn a daily profit share bonus of up to 1,500 pesos by having two direct recruits. Additional bonuses are offered for leadership, recruiting six members within seven days, and recruiting 50 members within 30 or 60 days to qualify for a new car. The Damayan program provides 10 pesos per active member to assist those experiencing grief.
This document summarizes the compensation plan and product offering for a multi-level marketing company called Yoli. It describes 9 ways for distributors to earn money, including retail profits, bonuses for starting and maintaining an autoship order each month. It also outlines a unilevel matching bonus plan with up to 10 levels, as well as global bonus pools and leadership bonuses. The company's flagship product called Alkatele is described as helping remove acid waste and support healthy pH levels.
This document provides information about a company that offers video-based communication products and services. It was founded in 2002 and is debt-free with a global market presence. The company's flagship products allow users to send video emails with pre-designed templates and video resumes and web conferences. It also offers live broadcasting and video file sharing capabilities. The business opportunity allows individuals to earn commissions from a binary compensation plan by building two teams and achieving a 4:2 ratio. Payouts can reach $5,000 per day at higher levels.
This document provides an overview of MVT Spark Global, a US-based, debt-free company founded in 2002 that develops internet-based products bringing the world closer together. It details the company's positive growth and infrastructure. The presentation also outlines the company's four main products available through a one-time payment including registration, web hosting, and a debit/payroll card. It then explains the compensation plan showing how representatives can earn commissions and bonuses as the business grows. Risks of not joining or delaying joining are also addressed.
1. Direct selling allows earning up to 50% retail profit from directly selling products.
2. Direct sponsoring earns P500 cash + P750 worth of products for every product package sold outright.
3. Matched sales earns a P1,500 cash pairing bonus and increases with additional pairs up to infinity.
This document provides an overview of MVT Spark Global, a US-based, debt-free company founded in 2002 that develops internet-based products. It describes the company's mission of bringing the world closer together and outlines its four main products available through a one-time payment. The document then explains MVT Spark Global's compensation plan, which uses a hybrid binary system to reward independent representatives and team builders. Representatives can earn commissions daily and weekly, with the potential to earn over $1.8 million per year by building a large team. Some risk is involved if an individual does not join or delays joining.
The document compares two types of loans offered by IVP Lending Corp: loans with collateral that require background checks, co-makers, and guarantors along with more documentation and a longer approval process; and loans without collateral that offer automatic qualification with minimal documentation. It then describes the qualifications, benefits, and rewards program for those who subscribe to IVP Lending, including accidental death insurance, an i-Care fund, ID cards, and a back office webpage. The rewards program provides direct and indirect rebates bonuses as well as loan rebates earned from the loans of those in your network levels.
YOLI helps people live healthier lives by providing health products and ingredients, and teaching people how to take control of their lives. It is a multimillion dollar business platform operating in the US, Malaysia, and Asia. The document discusses YOLI's compensation plan which offers many ways to earn money including retail profits, bonuses for starting fast and breaking even, team commissions, matching bonuses, and incentive trips. It promotes the benefits of the business like flexibility, tax advantages, and unlimited income potential.
The document compares two types of loans offered by IVP Lending Corp: loans with collateral that require background checks, co-makers, and guarantors with more documentation and a longer approval process; and loans without collateral that have automatic qualification with minimal documentation. It then describes the qualifications, benefits, and rewards program for becoming an IVP Lending affiliate, including accidental death insurance, an i-Care fund, website access, and the ability to earn direct and indirect rebates bonuses on loan volumes in one's network levels as well as loan rebates of 0.1-4% based on loan amounts.
The document compares two types of loans offered by IVP Lending Corp: loans with collateral that require background checks, co-makers, and guarantors with more documentation and a longer approval process; and loans without collateral that have automatic qualification and minimal documentation. It then describes the qualifications, benefits, and rewards program for becoming an IVP Lending representative, including accidental death insurance, an i-Care fund, ID, a webpage and back office access. The rewards program offers direct and indirect rebates bonuses on loan volumes in a representative's organization levels, as well as loan rebates percentages based on loan amounts on each level.
IVP LENDING CORP. - Presentation Transcript
IVP LENDING CORP.
With Collateral No CollateralSeries of background checking No Background CheckingNeeds Co-Maker No Co-MakerNeeds Guarantor No GuarantorTakes longer time to be qualified Automatic QualificationLots of Documents/Papers to comply Minimal Documents neededBig % INTEREST NO % INTEREST
How to Qualify?!One Subscription KitAccidental Death Insurance – up to P50,000i-Care fundI.DWebpage / Back Office
Rewards ProgramDirect Rebates BonusIndirect Rebates BonusLoan Rebates Bonus
Direct Rebates Bonus Receive Php500 Direct Rebates Bonus on your 1st Level. YOU A500 500 J B 500 I 500 C 500 H 500 500 D E 500 F 500 G 500
Indirect Rebates BonusReceive Php10 Indirect Rebates Bonus on your 2nd Level.Receive Php10 Indirect Rebates Bonus on your 3rd Level.Receive Php5 Indirect Rebates Bonus on your 4th Level.Receive Php5 Indirect Rebates Bonus on your 5th Level.
Rebates Projection Direct Rebates / Indirect Rebates Bonus YOU1st Level 102nd Level 1003rd Level 1,0004th Level 10,0005th Level 100,000
Loan RebatesReceive Php200 (4%) Loan Rebates for every Php5000 loan of your 1st Levels.Receive Php100 (2%) Loan Rebates for every Php5000 loan of your 2nd Levels.Receive Php10 (0.2%) Loan Rebates for every Php5000 loan of your 3rd Levels.Receive Php10 (0.2%) Loan Rebates for every Php5000 loan of your 4th Levels.Receive Php5 (0.1%) Loan Rebates for every Php5000 loan of your 5th Levels.
Rebates earned from your group’s loans YOU 1st Level 10 2nd Level 100 3rd Level 1,000 4th Level 10,000 5th Level 100,000
IVP LENDING CORP
The document compares two types of loans offered by IVP Lending Corp: loans with collateral that require background checks, co-makers, and guarantors with more documentation and a longer approval process; and loans without collateral that have automatic qualification and minimal documentation. It then describes the qualifications, benefits, and rewards program for becoming an IVP Lending affiliate, including accidental death insurance, an i-Care fund, website access, and the ability to earn direct and indirect rebates bonuses on loan volumes in one's network levels as well as loan rebates of 0.1-4% based on loan amounts.
Speedy Updated Presentation More Detailed With Productskaperahan dotbiz
Speedy Load & Merchandizing Network Inc. is a company that develops Independent Business Owners through a multi-business marketing system offering health, beauty, and wealth products. It provides opportunities in e-loading, merchandising, livelihood programs, and multiple income benefits. Members can earn through sponsoring others, sales commissions, and a unilevel marketing structure compensating members for product sales across 10 levels. The presentation outlines the company's business model and various compensation plans for members.
Speedy Load & Merchandizing Network Inc. is a company that develops Independent Business Owners through a multi-business marketing system offering health, beauty, and wealth products. It provides opportunities in e-loading, merchandising, livelihood programs, and income benefits. Members can earn through sponsoring others, sales commissions, and a unilevel marketing structure spanning 10 levels. The presentation outlines the company's products, business model, and multiple compensation plans including bonuses for sponsoring others and repeat purchases.
JuanCent is a Filipino-owned multi-level marketing company that offers online entertainment auctions and independent distributorships. It was established by industry leaders with expertise in IT and business marketing. As a member, you can earn rebates from bids and sales matches from your group A and B members. The compensation plan allows members to earn up to P512,000 per month through JuanCent's binary structure.
This document outlines the business opportunity and compensation plan for an online direct selling company called DSL. Key points include:
- DSL operates in the telecommunications market with over 80 million potential customers in the Philippines.
- To start, one pays P4,888 to become a subscriber and gain access to DSL's products and marketing plan.
- The compensation plan includes bonuses paid on enrolling new distributors as well as revenues from product sales and transactions within one's distribution network.
- The document promotes several incentives for growth such as cash bonuses, travel rewards, and ownership of lucrative depot and stockist positions within DSL.
1. The document describes the compensation plan and product benefits of a multi-level marketing company. It outlines the various bonuses, commissions, and incentives distributors can earn such as daily payouts, discounts, and a scholarship program.
2. The binary plan and unilevel structures are explained as ways for distributors to earn income based on their sales volume and the sales of those in their downline. Examples are given of potential earnings at different organizational levels.
3. A comparison shows that the potential earnings from the MLM plan after three months greatly exceeds what could be earned from a bank time deposit over the same period, highlighting the higher returns possible through the opportunity.
3. ALLIANCE IN MOTION GLOBAL, INC.
Investment???
P6000 worth of
P7980 PRODUCTS
Main
4. BENEFITS
Global Package
(5boxes of C24/7 150 Vcaps worth P 6,000)
25% Discount on ALL products!
Insurance Package
P200,000 Accident Insurance
P50,000 Unprovoked Murder
P10,000 Burial Assistance
P10,000 Medical Reimbursement Main
5. BENEFITS
ATM (No maintaining balance)
BDO / BPI
Business Kit
FREE Medical Checkup
SCHOLARSHIPS!!!
10% Discount on SELECTED items in Ororama
10% Discount on Dr. Rose Uy – Mijares’ Dental Services
P25 per container with FREE DELIVERY from Freshka
Purified Water Main
7. BENEFITS 5 in 1!!!
(with initial investment of P 7,980)
Health - C24/7
Protection - Insurance
Education - Scholarship
Travel Incentives
Business - Hybrid Marketing Plan
8. ALLIANCE IN MOTION GLOBAL, INC.
Hybrid Marketing Plan
Basics
Binary System
Uni-level System
Stair-step
7-Account Strategy
Main
9. WAYS to EARN (The Basics) Menu
* 25% Retail Profit
* P500 Direct Referral Bonus
(You are the SPONSOR)
* P1,500 for every 1,200 pts. from your
LEFT and RIGHT
10. BINARY SYSTEM Menu
LEFT RIGHT
YOU
A B
1st cycle
Spill-over
12:00mn - 11:59am
C D
2nd cycle
12:00nn - 11:59pm
E F H
G
11. REPEAT BINARY SYSTEM Menu
LEFT RIGHT Every Pair = P1500!!!
YOU
Reorder!
1,200 pts!!!
A B Reorder!
C Reorder! PAIRING
is until
INFINITY
Registration (1200pts.) + Registration (1200pts.) = P1500!!!
Registration (1200pts.) + Product Reorder (1200pts.) = P1500!!!
Product Reorder (1200pts.) + Product Reorder (1200pts.) = P1500!!!
12. Menu
Requirement
to obtain the
unilevel
YOU commission
is only 2
Blister
A B Packs/month.
C D
E H
F I
5th PAIR I
G J 10th PAIR II Gift Checks for
15th PAIR III Product Purchase
20th PAIR IV
Sodexho Checks
25th PAIR V for
SHOPPING
13. Menu
If C & D, both on the 2nd
YOU
level, have not made any
re-orders for the current
month… A B
… Then, E, F, G, H, C D
I & J on the lower
levels, considering E F
they made re-orders,
will be pushed up to G H I
occupy the upper
levels. J
Thus, we are assured
that the 1st 10 levels will
be occupied by those
who made re-orders…
14. Menu
Free trip
30% up
to
Year-end Profit
infinity Sharing!!!
20% up
to
GLOBAL
infinity AMBASSADOR
10% up Gold
to
infinity Executive
Silver
0% Executive
Distributor
Pass Up