Marijuana has a long history of use dating back to 500 AD when it spread from China to other parts of the world. It was introduced to the Americas in the 1500s and became a major commercial crop. While it was used medically in the past, it is now a Schedule I drug. Marijuana can be administered through smoking, vaporizing, eating, or applying topically. It contains over 400 chemicals but THC is the main active compound. Short term effects include increased heart rate and anxiety, while long term effects involve changes to the immune, endocrine, and nervous systems.