1) The document discusses using Discoverant software to optimize manufacturing processes by gathering and analyzing data from production.
2) Discoverant allows companies to gather data from multiple sources, perform analysis to identify issues, and optimize processes to improve throughput, quality and costs.
3) The presentation will make the business case for implementing Discoverant by detailing how it can help companies achieve business goals and better serve their markets.
The document appears to contain numerical data across multiple categories including potential threats, equipment types, response times, and other factors. The data includes 77 entries with values ranging from -0.087866 to 0.246748 for the first category. Location or device-based data is also included for some categories.
The document provides a table of thermophysical properties of refrigerant 22 (chlorodifluoromethane) at various temperatures ranging from -100°C to 32°C. For each temperature, the table lists properties of saturated liquid and saturated vapor including pressure, density, enthalpy, entropy, specific heat, and more. The extensive table acts as a reference for engineers to look up refrigerant 22 properties under different temperature conditions.
1) This document provides a stock analysis for various companies listing key support and resistance levels as well as changes in open interest and closing prices for futures contracts expiring on August 29th, 2013.
2) It was published by Mansukh Securities and Finance Ltd on August 27th, 2013 and includes disclosure statements at the end.
3) The analysis contains information on over 50 stocks traded on Indian exchanges such as NIFTY, BANKNIFTY, and individual companies.
The document appears to be a table containing stock price and valuation data for multiple companies. It includes columns for stock price, estimated fair price, percentage difference between current and fair price, and other valuation metrics. The table contains data for over 100 stock ticker symbols.
This document provides a summary of key support and resistance levels for futures and options contracts on various stocks and indices trading on Indian exchanges, such as Nifty, Bank Nifty, CNXIT, based on open interest and price changes as of February 1, 2012. It lists the underlying, lot size, open interest, change in open interest, percentage change in open interest, percentage change in closing price, support 1 and 2 levels and resistance 1 and 2 levels for each stock future and index future contract expiring on February 23, 2012.
This document contains tables of compound interest factors for interest rates of 0.25% and 0.5% compounded annually over various time periods from 1 to 480 years. The tables show the compound amount, present worth, sinking fund, capital recovery, uniform series, and gradient factors for single payments, arithmetic gradients, and present worth calculations.
The document describes solving a nonlinear equation using the fixed point and Newton-Raphson methods in MATLAB. It provides the equation, a graph of the equation, the MATLAB code for implementing the fixed point method and results, and the MATLAB code for implementing the Newton-Raphson method and results. The results show the iterative approximations converging to the root for each method over multiple iterations.
The document appears to contain numerical data across multiple categories including potential threats, equipment types, response times, and other factors. The data includes 77 entries with values ranging from -0.087866 to 0.246748 for the first category. Location or device-based data is also included for some categories.
The document provides a table of thermophysical properties of refrigerant 22 (chlorodifluoromethane) at various temperatures ranging from -100°C to 32°C. For each temperature, the table lists properties of saturated liquid and saturated vapor including pressure, density, enthalpy, entropy, specific heat, and more. The extensive table acts as a reference for engineers to look up refrigerant 22 properties under different temperature conditions.
1) This document provides a stock analysis for various companies listing key support and resistance levels as well as changes in open interest and closing prices for futures contracts expiring on August 29th, 2013.
2) It was published by Mansukh Securities and Finance Ltd on August 27th, 2013 and includes disclosure statements at the end.
3) The analysis contains information on over 50 stocks traded on Indian exchanges such as NIFTY, BANKNIFTY, and individual companies.
The document appears to be a table containing stock price and valuation data for multiple companies. It includes columns for stock price, estimated fair price, percentage difference between current and fair price, and other valuation metrics. The table contains data for over 100 stock ticker symbols.
This document provides a summary of key support and resistance levels for futures and options contracts on various stocks and indices trading on Indian exchanges, such as Nifty, Bank Nifty, CNXIT, based on open interest and price changes as of February 1, 2012. It lists the underlying, lot size, open interest, change in open interest, percentage change in open interest, percentage change in closing price, support 1 and 2 levels and resistance 1 and 2 levels for each stock future and index future contract expiring on February 23, 2012.
This document contains tables of compound interest factors for interest rates of 0.25% and 0.5% compounded annually over various time periods from 1 to 480 years. The tables show the compound amount, present worth, sinking fund, capital recovery, uniform series, and gradient factors for single payments, arithmetic gradients, and present worth calculations.
The document describes solving a nonlinear equation using the fixed point and Newton-Raphson methods in MATLAB. It provides the equation, a graph of the equation, the MATLAB code for implementing the fixed point method and results, and the MATLAB code for implementing the Newton-Raphson method and results. The results show the iterative approximations converging to the root for each method over multiple iterations.
The document is a table providing thermodynamic properties of saturated steam including temperature, pressure, specific volume, internal energy, enthalpy, and entropy at different temperature and pressure values. It contains data for saturated liquid, saturated steam, and the heat of vaporization. The table includes properties for temperatures ranging from 0 to 374 degrees C and pressures from 0.001 to 1013 kPa.
The document contains a table that lists angles in both grados and radians along with their corresponding sine, cosine, and tangent values. The table ranges from -180 to 180 degrees or -π to π radians in increments of 4 degrees/radians. It shows how the sine, cosine, and tangent values change as the angle increases, with sine and cosine values ranging from -1 to 1 and tangent values getting larger as the angle approaches π/2 radians.
This document provides a summary of key support and resistance levels for various stocks and indexes in the futures and options market. It lists the underlying asset, open interest, change in open interest, percentage change in open interest, percentage change in closing price, support levels, resistance levels, and expiry date. The levels provided can help traders and investors identify potential price points where demand/supply may increase for each underlying asset.
- The document provides a table summarizing key support and resistance levels for various stocks and indices based on futures open interest and price changes as of July 8, 2013.
- It lists stock futures, their underlying, lot size, open interest, change in open interest, and percentage changes in open interest and closing price.
- Support and resistance levels are provided for each stock future to indicate possible price points where buying or selling pressure may increase.
- The table is from Mansukh Securities and Finance Ltd and is intended for private circulation only to their clients.
This document contains tables of compound interest factors for interest rates of 1/4%, 1/2%, and 3/4% compounded annually. The tables show the factors needed to calculate future and present values of single payments, uniform series payments, and arithmetic gradient series payments over a range of time periods from 1 to 480 years.
This document provides key support and resistance levels for various stocks and indexes in the futures and options market as of August 7, 2013. It lists the open interest, change in open interest, and change in closing price for various stocks. It also gives support and resistance levels (S1, S2, R1, R2) to watch for different stocks and notes an expiry date of August 29, 2013 for futures contracts.
This document provides a summary of key support and resistance levels for various stocks and indices based on their futures trading on June 10, 2013. It lists the underlying, open interest, change in open interest, percentage change in open interest, percentage change in closing price, support levels, resistance levels, and closing price for each stock future contract expiring on June 27, 2013. The document is from Mansukh Securities and Finance Ltd and includes important disclosures at the end.
Tabel uap untuk membantu dalam meyelesaikan persoalan pada pengolahan pangan. Cari lebih banyak di; http://muhammadhabibielecture.blogspot.com/2015/02/materi-kuliah-semester-4.html
The document contains two tables providing future value interest factors for one dollar and one dollar annuities compounded at various interest rates over different periods of time. Table A-1 shows the future value of $1 invested at rates from 1% to 30% over periods from 1 to 30 years. Table A-2 shows the future value of a $1 annuity invested at the same rates and periods. The tables allow users to determine the future values of single investments and annuities based on the interest rate and time horizon.
This document provides a summary of key support and resistance levels for various stocks and indexes in the futures and options market as of July 19, 2013. It lists the open interest, change in open interest, and support and resistance levels for indexes like Nifty 50, Bank Nifty and stocks from various sectors like banking, FMCG, oil and gas, metals, etc. It also provides the expiry date for the current futures and options contracts as July 25, 2013.
The document contains tables listing future value interest factors and future value interest factors of an ordinary annuity for interest rates ranging from 1% to 20% over periods of 1 to 40 years. The future value interest factor table shows the factor needed to calculate the future value of a present amount given a certain interest rate and time period. The future value interest factor of an ordinary annuity table shows the factor required to calculate the future value of an annuity with regular payments made over a certain time period.
This document provides a summary of key support and resistance levels for various stocks and indexes in the futures and options market. It lists the underlying asset, open interest, change in open interest, and support and resistance levels based on the previous day's closing price. The disclosure at the end indicates this is an internal report for clients of Mansukh Securities and Finance Ltd, an Indian brokerage firm.
1) The document is a daily report on key support and resistance levels for futures and options contracts of various stocks trading on Indian exchanges.
2) It provides data like open interest, change in open interest, support and resistance levels for different stocks.
3) The report is intended for private circulation only among clients of the publishing company.
1) The document provides key support and resistance levels for various stocks and indexes in the futures and options market as of May 28, 2013.
2) It lists the open interest, change in open interest, and change in closing price for various stocks trading on Indian exchanges such as NSE and BSE.
3) Support and resistance levels are given to analyze where prices may pause their upward or downward movement in the short term.
This document provides a key support and resistance levels for various stocks and indexes in the futures and options market as of July 23, 2013. It lists the open interest, change in open interest, support and resistance levels for 50 stocks, along with the Nifty 50 and Bank Nifty indexes. The expiry date for the futures contracts is July 25, 2013. It is a daily technical report from Mansukh Securities and Finance Ltd to their clients.
MR. AMIR IKRAM is a resource person with an MPhil from GC University Lahore and an MBIT in Finance from Punjab University. The document contains tables with values for future value (FV), present value (PV), and other time value of money calculations at varying interest rates and time periods. The tables provide the calculations for interest rates from 2% to 18% and time periods from 1 to 50 years for future value, and periods from 1 to 20 years for present value.
This document provides a key support and resistance levels for various stocks and indexes in the futures and options market. It lists the underlying asset, open interest, change in open interest, previous day's close price, support and resistance levels for each. The overall summary is that it analyzes the performance and trading volumes of various stocks in the F&O segment from the previous day.
Como se utiliza la tabla t de student (formulas)Zully HR
The document contains tables of values with increasing levels from 0.55 to 0.995. The values seem to correspond to statistical calculations for levels of significance and critical values.
The document simulates gym capacity at the Töölö Unisport gym in Helsinki based on arrival rates. It uses an exponential distribution to simulate customer inter-arrival times based on historical crowdedness data. It assigns customers to different exercise machines and tracks their waiting times. The simulation is run multiple times to analyze average waiting times and system capacity under different arrival rates.
This document contains a table of critical values for the chi-square distribution with degrees of freedom (df) ranging from 0 to 136 and significance levels of 0.1, 0.05, 0.025, 0.001, and 0.005. The table lists the critical value that corresponds to each combination of df and significance level.
Sample Calculations for solar rooftop project in Indiadisruptiveenergy
This document provides a financial analysis of a proposed solar PV rooftop project over 25 years. It outlines key steps and parameters to consider, including net metering rules, installation costs, internal rate of return, return on investment, payback period, lifetime savings, and discount rate. Tables show projected annual energy generation, costs, revenues, and financial metrics to help evaluate the project's feasibility and profitability. The analysis aims to help consumers make informed decisions without being misled by inaccurate information from solar companies or officials.
This document provides performance objectives and nutritional recommendations for Cobb500 broilers. It includes target weights, daily gains, feed conversions, and daily feed intake for male and female broilers from hatch to 56 days. Recommended nutrient levels for medium/large and small broilers are also presented. The goals are to help farmers efficiently raise broilers with good livability, welfare, and yield performance through genetic improvements and optimized nutrition programs.
The document is a table providing thermodynamic properties of saturated steam including temperature, pressure, specific volume, internal energy, enthalpy, and entropy at different temperature and pressure values. It contains data for saturated liquid, saturated steam, and the heat of vaporization. The table includes properties for temperatures ranging from 0 to 374 degrees C and pressures from 0.001 to 1013 kPa.
The document contains a table that lists angles in both grados and radians along with their corresponding sine, cosine, and tangent values. The table ranges from -180 to 180 degrees or -π to π radians in increments of 4 degrees/radians. It shows how the sine, cosine, and tangent values change as the angle increases, with sine and cosine values ranging from -1 to 1 and tangent values getting larger as the angle approaches π/2 radians.
This document provides a summary of key support and resistance levels for various stocks and indexes in the futures and options market. It lists the underlying asset, open interest, change in open interest, percentage change in open interest, percentage change in closing price, support levels, resistance levels, and expiry date. The levels provided can help traders and investors identify potential price points where demand/supply may increase for each underlying asset.
- The document provides a table summarizing key support and resistance levels for various stocks and indices based on futures open interest and price changes as of July 8, 2013.
- It lists stock futures, their underlying, lot size, open interest, change in open interest, and percentage changes in open interest and closing price.
- Support and resistance levels are provided for each stock future to indicate possible price points where buying or selling pressure may increase.
- The table is from Mansukh Securities and Finance Ltd and is intended for private circulation only to their clients.
This document contains tables of compound interest factors for interest rates of 1/4%, 1/2%, and 3/4% compounded annually. The tables show the factors needed to calculate future and present values of single payments, uniform series payments, and arithmetic gradient series payments over a range of time periods from 1 to 480 years.
This document provides key support and resistance levels for various stocks and indexes in the futures and options market as of August 7, 2013. It lists the open interest, change in open interest, and change in closing price for various stocks. It also gives support and resistance levels (S1, S2, R1, R2) to watch for different stocks and notes an expiry date of August 29, 2013 for futures contracts.
This document provides a summary of key support and resistance levels for various stocks and indices based on their futures trading on June 10, 2013. It lists the underlying, open interest, change in open interest, percentage change in open interest, percentage change in closing price, support levels, resistance levels, and closing price for each stock future contract expiring on June 27, 2013. The document is from Mansukh Securities and Finance Ltd and includes important disclosures at the end.
Tabel uap untuk membantu dalam meyelesaikan persoalan pada pengolahan pangan. Cari lebih banyak di; http://muhammadhabibielecture.blogspot.com/2015/02/materi-kuliah-semester-4.html
The document contains two tables providing future value interest factors for one dollar and one dollar annuities compounded at various interest rates over different periods of time. Table A-1 shows the future value of $1 invested at rates from 1% to 30% over periods from 1 to 30 years. Table A-2 shows the future value of a $1 annuity invested at the same rates and periods. The tables allow users to determine the future values of single investments and annuities based on the interest rate and time horizon.
This document provides a summary of key support and resistance levels for various stocks and indexes in the futures and options market as of July 19, 2013. It lists the open interest, change in open interest, and support and resistance levels for indexes like Nifty 50, Bank Nifty and stocks from various sectors like banking, FMCG, oil and gas, metals, etc. It also provides the expiry date for the current futures and options contracts as July 25, 2013.
The document contains tables listing future value interest factors and future value interest factors of an ordinary annuity for interest rates ranging from 1% to 20% over periods of 1 to 40 years. The future value interest factor table shows the factor needed to calculate the future value of a present amount given a certain interest rate and time period. The future value interest factor of an ordinary annuity table shows the factor required to calculate the future value of an annuity with regular payments made over a certain time period.
This document provides a summary of key support and resistance levels for various stocks and indexes in the futures and options market. It lists the underlying asset, open interest, change in open interest, and support and resistance levels based on the previous day's closing price. The disclosure at the end indicates this is an internal report for clients of Mansukh Securities and Finance Ltd, an Indian brokerage firm.
1) The document is a daily report on key support and resistance levels for futures and options contracts of various stocks trading on Indian exchanges.
2) It provides data like open interest, change in open interest, support and resistance levels for different stocks.
3) The report is intended for private circulation only among clients of the publishing company.
1) The document provides key support and resistance levels for various stocks and indexes in the futures and options market as of May 28, 2013.
2) It lists the open interest, change in open interest, and change in closing price for various stocks trading on Indian exchanges such as NSE and BSE.
3) Support and resistance levels are given to analyze where prices may pause their upward or downward movement in the short term.
This document provides a key support and resistance levels for various stocks and indexes in the futures and options market as of July 23, 2013. It lists the open interest, change in open interest, support and resistance levels for 50 stocks, along with the Nifty 50 and Bank Nifty indexes. The expiry date for the futures contracts is July 25, 2013. It is a daily technical report from Mansukh Securities and Finance Ltd to their clients.
MR. AMIR IKRAM is a resource person with an MPhil from GC University Lahore and an MBIT in Finance from Punjab University. The document contains tables with values for future value (FV), present value (PV), and other time value of money calculations at varying interest rates and time periods. The tables provide the calculations for interest rates from 2% to 18% and time periods from 1 to 50 years for future value, and periods from 1 to 20 years for present value.
This document provides a key support and resistance levels for various stocks and indexes in the futures and options market. It lists the underlying asset, open interest, change in open interest, previous day's close price, support and resistance levels for each. The overall summary is that it analyzes the performance and trading volumes of various stocks in the F&O segment from the previous day.
Como se utiliza la tabla t de student (formulas)Zully HR
The document contains tables of values with increasing levels from 0.55 to 0.995. The values seem to correspond to statistical calculations for levels of significance and critical values.
The document simulates gym capacity at the Töölö Unisport gym in Helsinki based on arrival rates. It uses an exponential distribution to simulate customer inter-arrival times based on historical crowdedness data. It assigns customers to different exercise machines and tracks their waiting times. The simulation is run multiple times to analyze average waiting times and system capacity under different arrival rates.
This document contains a table of critical values for the chi-square distribution with degrees of freedom (df) ranging from 0 to 136 and significance levels of 0.1, 0.05, 0.025, 0.001, and 0.005. The table lists the critical value that corresponds to each combination of df and significance level.
Sample Calculations for solar rooftop project in Indiadisruptiveenergy
This document provides a financial analysis of a proposed solar PV rooftop project over 25 years. It outlines key steps and parameters to consider, including net metering rules, installation costs, internal rate of return, return on investment, payback period, lifetime savings, and discount rate. Tables show projected annual energy generation, costs, revenues, and financial metrics to help evaluate the project's feasibility and profitability. The analysis aims to help consumers make informed decisions without being misled by inaccurate information from solar companies or officials.
This document provides performance objectives and nutritional recommendations for Cobb500 broilers. It includes target weights, daily gains, feed conversions, and daily feed intake for male and female broilers from hatch to 56 days. Recommended nutrient levels for medium/large and small broilers are also presented. The goals are to help farmers efficiently raise broilers with good livability, welfare, and yield performance through genetic improvements and optimized nutrition programs.
The document lists American Wire Gauge (AWG) wire sizes from 36 to 2000 in both imperial and metric units, providing the wire diameter, cross-sectional area, and standard size for each listing. Wire sizes range from 0.0050 inches to 2 inches in diameter, and include common wire gauges for solid copper conductors used in electrical work.
This document contains tables of thermodynamic property data for steam in SI units. It includes saturation temperature, saturation pressure, superheated vapor, and compressed liquid tables. The tables provide properties such as specific volume, enthalpy, entropy, and others over a range of temperatures and pressures. The document was prepared for an engineering course at Michigan State University and includes contact information for the professor.
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The document contains a table of numbers organized in rows and columns. The first column contains probability values from 0.1 to 0.005 decreasing by factors of 2. The remaining columns contain sets of numbers that decrease as the probability values decrease.
This document contains two pages of tables with values for sin, cos, and tan functions evaluated at different values. The first page contains values from 1 to 12, and the second page contains values from 1 to 89. For each value, the sin, cos, and tan are provided to 3 decimal places. The tables provide function values for evaluation over a range of inputs.
This document contains a table with percentiles for the chi-squared distribution across various degrees of freedom (g.l.) and significance levels. It shows the critical value needed to reject the null hypothesis for different sample sizes and confidence levels in chi-squared tests of independence and goodness of fit.
This document contains a list of 45 data points with two values each: a numeric x-value and a corresponding y-value. The x-values range from 0.7943283 to 100 in increasing order, while the y-values decrease from 102.4378 to 0.00174015 as x increases.
This document provides stock price data for 8 companies (TSLA, AMZN, WMT, AAPL, F, DIS, IBM, MSFT) from July 2010 to December 2016 in a table with the adjusted closing price for each stock listed for each month. The data will be used for a project analyzing the efficient frontier for a portfolio of these stocks.
The document appears to be a table containing statistical data with right tail probabilities for the t distribution. The table includes degrees of freedom (df) ranging from 1 to 30 across the top. Under each df is a column of p-values ranging from 0.40 to 0.0005. The body of the table contains the corresponding t-statistic for each intersection of df and p-value. Below the table is a website url and email for an organization called Marketing Utopia.
The document appears to be a table containing statistical data with right tail probabilities for the t distribution. The table includes degrees of freedom (df) ranging from 1 to 30 across the top. Under each df is a column of p-values ranging from 0.40 to 0.0005. The body of the table contains the corresponding t-statistic for each intersection of df and p-value. Below the table is a website URL and email address.
This document provides specifications for Moyno G2 and G3 series pumps including dimensions and weights. It lists various pump frame sizes from 1E008G2 to 6K175G2 with corresponding measurements and discharge weights at different pipe lengths. Key dimensions included are flange size, length and diameter of pump components. The page notes that dimensions are in inches and provides contact information for Moyno pumps.
The document contains data from a conductivity test conducted over time on a solution with a concentration of magnesium. It includes measurements of conductivity, concentration, mass, load, and other variables taken at 10 second intervals from 10 to 430 seconds. The data is presented in a table and two graphs show trends in concentration and mass over time.
The document appears to be a table containing 99 rows of data with fields for field price, increase with gold, C/B with gold, total with gold, and other numeric values. The table shows calculations for field price increases along with cost-benefit analyses including gold values across 99 entries.
This document appears to contain time series data from 1952 to 1989 with annual observations of GDP, M1 money supply, inflation rate (PR), and interest rate (RS) for the United States. The data is organized by year and period (quarterly) with corresponding values listed for each economic indicator.
The document contains tables of values with increasing levels from 0.55 to 0.995. The values seem to relate to statistical calculations for determining critical values and levels of significance across different sample sizes and distributions.
The document contains measurements of the distance and azimuth from trees to a central point in 4 different quadrants. For each tree, it lists the quadrant, tree number, distance, azimuth, radians, sine, cosine, and x and y coordinates. There are a total of 32 trees measured across the 4 quadrants.
Similar to Manufacturing Process Optimization Using Statistical Modeling 2015 (20)
Manufacturing Process Optimization Using Statistical Modeling 2015
1. Manufacturing Process Optimization
Utilizing Discoverant
Maximizing production throughput with
less effort
1
Ron Ortiz, Director Six Sigma, Operational Excellence
BIOVIA UGM, May 2015
2. 2
Though rare, if applied early in a company’s lifecycle during tech
transfer or early in commercialization, process optimization can
unlock key business drivers such as cycle time or yield to
accelerate profitability.
Discoverant’s powerful suite of tools and analytics can enable
small up and coming Biotech companies to immediately drive cost
down while improving quality. The margin effect can be very
dramatic.
This presentation details the business case for implementing
Discoverant to achieve business driven results both for the
company and the market you serve.
Abstract
3. Agenda
• Discoverant and your manufacturing value stream
• Three Steps to turn data into information
1. Gather Data Brute force data gathering, formatting & analysis
2. Analyze Data Mind the gap … holes in your limited analysis
3. Optimize Process Drowning in a sea of data
• The Discoverant value proposition
• Bang for the buck & what Discoverant eliminates
3
4. New Manufacturing Data Collection Landscape
Eng
Maint
HISTLIMSERP CAPA MES
Paper Records
Raw
Materials
Process
Step 1
Process
Step 2
Process
Step 3
Process
Steps…
Final
Product
MS EXCELBIOVIA Discoverant
5. Step One: Gather Data
• Straightforward right?
– Which data?
– How much data?
– What timeframe?
– What format?
– Nominal versus discrete? (What’s that even mean?!?!)
• From Paper-based to spreadsheet to complex
equipment systems – gathering data is not
straightforward…
5
7. Step Two: Analyze Data
• Time to hire a consultant…
– Or an Operational Excellence person
– Or statistician?
– Or bioinformatics?
– Or???
• Turning seas of data into drinkable information is both
art and science. It helps if you have end to end
process understanding… not many do
7
9. This looks promising! But now what???
9
The model appears to follow quite nicely with the actual results… but there are gaps
10. Step Three: “Optimizing” Your Process…
• Questions should abound at this point
– What does the analysis mean?
– Did I use the right data?
– Did I use enough data?
– Which are the most important?
• The most common pitfall in process optimization is
not having the right level of predictive capability – in
other words Root Cause.
10
11. Manually Gathered Data Is Often Limiting…
11
MRP
Raw Material
Purchase
BOM item
Supplier
Lead Time
Agreed Delivery
Date
Order Size
Unit of Measure
Price
MRP
Raw Material
Receipt
Received Date
Quantity
Received
C of A (Multiple
Parameters)
Supplier Lot #
Expiry Date
XL Spreadsheet
Raw Material
Test Results
(Multiple
parameters)
Weighing and
Dispensing
MRP
BOM item
(multiple)
Lot kit
Weight
Volume
Raw Material
Combo 1
Historian Batch Record
Supplier lot #
and amount
for each:
RAW 1
RAW 2
RAW 3
RAW4
RAW5
AWFI
(amount)
Solvent amount
Mixing time
Temperature
Pressure
Tank Weight
Raw Material
Combo 2
Historian
Amount of AWFI
Mixing time
Pressure
Tank Weight
Batch Record
Supplier lot #
and amount
for RAW 6
Mixing Step 1
Historian
Historian
Raw Material
Combo 3
RAW 7 lot #
and the
amount
RAW 8 lot #
and the
amount
AWFI amount
Temperature
Batch Record
Mixing Step 2
Historian
Time
Pressure
Mixing Speed
Ramp time
Total Mixing time
Conductivity
Temperature
Filtration Step
Batch Record Log Book
Lot #
Number
of uses
Concentration
Step 1
Conductivity
Dilution Transfer time
Buffer Exchange qty
Buffer Exchange transfer time
Buffer exchange flow rate
Temperature
Pressure
Historian
Finished Product
Transfer
Historian
Bulk volume
Temperature
Pressure
Finished Product
Hold
Saline amount
Lot #
Batch record
Inspection Sampling
Saline added
Lot #
Batch record
QC Release
XL Spreadsheet
Tank farm hold
Log Book
Tank ID
Lot #
Time
Temperature
Filling
XL Spreadsheet
Packaging& Labeling
Paper based
record
P&L Loss
Total Cartons
XL Spreadsheet
Initial Bulk
concentration
XL Spreadsheet
Final Bulk
concentration
Amount of AWFI
Pressure
Combo 1 transfer time
Combo 1 transfer amount
Combo 2 transfer time
Combo 2 transfer amount
Mixing Speed
Ramp time
Total mix time
Conductivity
Temperature
Release Test 1
Release Test 2
Release Test 3
Release Test 4
Release Test 5
Release Test 6
Release Test 7
Release Test 8
Release Test 9
Release Test 10
Release Test 11
Release Test 12
Release Test 13
Release Test 14
Lot #
Bulk Date
Fill Date
Hold Time
Fill Time
Tank ID
Theoretical Yield
Total vials filled
Filled vials to inspection
Acceptable Inspected vials
Vials to Inventory
Line Loss
Purge loss
Split Loss
Crimp Reject
Weight Check Loss
Other reject
Low/High reject
Dark
Light
Fiber
The previous data set
represented less than
15% of the total
possible parameters
measured
As a result the model
can only explain
~59% of the results..
Good but not great.
12. The Discoverant Value Proposition
• Time savings in data gathering, formatting & analysis
– What’s the cost to have operators, scientists & engineers
data hunting versus producing, discovering & designing?
• In our case, with over 200 hundred parameters it equates to
approximately 3 full time headcount (fully burdened)
• Material savings in avoiding lost production batches
– What’s the cost to throw materials away during production
or reject finished goods lots at QC weeks after?
• In our case anywhere from $20K to $500K depending on where in
the process the scrap occurred
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13. 3rd Party
LIMSELN
Accelrys
EBRLES PRIMR
DATAACCESS&AGGREGATION
NexusInvisionModules
External DatabasesBIOVIA Product Suite
Accelrys
LIMS
Historian 3rd Party
EBR/MES ERP
Data
Ware-
house
Tabular Data
Process/Product
Monitoring
Investigational
Analysis
Stability
Analysis
SPC
Feature
Extraction
REPORTING&COLLABORATION
Quantitative
Analysis
Chromatography
/Phase Analysis
Dynamic Mapping Engine
CONTEXTUALIZATION
DIRECT CONNECTS
BIOVIA Discoverant Activities
14. Discoverant Harmonizes Four Important Tools
1. It acts as a data warehouse
– Content aggregation from disparate systems
2. It becomes your prime report generator
– Dashboards and standard/custom reports for multiple org levels
3. It performs statistical analysis and modeling*
– Process Optimization want to maximize yield, at optimal
concentration without losing lots later to OOS test results? I do!
4. Manufacturing monitoring during the production
process
– Course corrections in real time to avoid in-process scrap
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*Multiple Linear Regression Modeling using derived parameter functionality
15. Summary: Discoverant offers powerful capability.
• Automated and preformatted data gathering
• Customizable report generation
• Advanced statistical analysis to enable root cause
identification and optimization faster and with less
resources
• Parametric release? Stay tuned
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