2. OUTLINE
• Definition
• Etiology
• Approach
a. Primary survey
b. Secondary survey
c. Treatment and management
• Prognosis
• Conclusion
3. Definitions
• Consciousness; refers to the state of being awake and aware of one’s surroundings. Requires both
wakefulness and awareness.
• Unconsciousness; refers to a state in which the patient is totally unaware of both self and external
surroundings, and unable to respond meaningfully to external stimuli. Here a patient lacks both
wakefulness and awareness.
• Syncope/fainting; refers to the brief loss of consciousness from which the patient recovers
spontaneously or with slight help.
• Coma; unarousable unresponsiveness. Deep, prolonged unconsciousness. Also defined as a Glasgow
coma scale score of <8 or a score of U on the AVPU scale.
4. Etiology and pathophysiology
• Unconsciousness is caused by impairment of reticular activating system(ARAS)
which is a system of the upper brainstem and the thalamic neurons. This system with
its broad connections to the cerebral hemispheres help maintain wakefulness.
• Alteration in alertness can be caused by Focal lesion directly damaging the ARAS ,
Damage to the cerebral hemispheres
6. Approach to an unconscious patient
• DON’T PANIC, call for help.
• An alteration in arousal represents an acute life threatening emergency
• Early physiological stability and diagnosis are vital in preservation of
life and brain function.
11. Exposure =E
• General exam -cyanosis, anemia, lymphadenopathy, dehydration.
• Examine the head for Swelling, bruising(racoon eyes, battle sign),
lacerations and bleeding.
• CSF rhinorrhea-skull fracture
• Neck rigidity- meningitis.
• Needle tracks-IV drug use
• Tongue bitten on the side-recent convulsive seizure
• Temperature
12. Secondary survey (focused history and examination)
• Performed after initial assessment after life threatening problems are found and
corrected
• Main purpose is to discover and care for a patient’s specific injuries or medical
problems
• Includes:
• obtaining patient relevant history
• Rapid assessment or focused assessment
• Repeating vital signs
13. Secondary survey…
• Ample patient history
• Obtained from bystanders/ family
• Mnemonic to obtain ample history:
• S – Signs/ symptoms
• A – Allergies
• M – Medications
• P – relevant past medical history
• L – Last oral intake
• E – Events leading to the illness or injury
14. History cont..
Recent illness
• fever – infection
• increasing headache- expanding intracranial pressure, venous sinus
Thrombosis
• recent fall-subdural hematoma
• recent confusion or delirium-metabolic or toxic cause
Prescription or non prescription drugs
Medical or psychiatric conditions
Previous hospital records should be requested urgently and next of kin
contacted.
Patients personal effects-medical alert bracelet or necklace or card in
wallet
15. Examination
After the initial ABC assessment, the level of consciousness should be formally
measured and documented using the GCS score.
A focused neurological examination should be undertaken.
Other systemic examinations should also be fully done.
The pattern of breathing should be assessed as well as the respiratory rate
• Kussmaul breathing; deep labored breathing indicative of severe metabolic
acidosis
• Ataxic breathing; groups of quick, shallow inspirations followed by regular or
irregular periods of apnea, suggests a lesion in the lower pons.
• Cheyne-stokes breathing; consists of cycles of deep, faster breathing followed
by shallow, slower breathing and moments of apnea
• Central neurologic hyperventilation; characterized by deep, rapid breaths at a
rate of at least 25breaths per minute. Indicates a lesion in the pons or
midbrain.
16. Investigations
Blood tests;
CBC, LFTs, RFTs, electrolytes, blood grouping and crossmatch, cardiac
markers(troponin, cytokine kinase), RBS, Blood cultures, MRDT, toxicology screen,
arterial blood gases.
imaging;
• CT or MRI of the head.
• X-ray in chest and abdominal related causes.
• Ultrasonography in trauma(e-FAST).
• ECG
Others
• Lumbar puncture
• CSF analysis
• EEG in suspected cases of non-convulsive status epilepticus.
17. Treatment and management
Management of an unconscious patient requires a multi disciplinary approach and team
work.
As the ABC assessment is undertaken, other team members should be;
• Taking blood tests
• Establishing intravenous access
• Connecting the patient to a cardiac monitor and oxygen probes
• Commencing appropriate oxygen therapy if indicated
Death will occur soonest if airway and breathing are compromised therefore the need
for intubation in patients with a GCS score of <8, those who can not protect their
airway, those with an ineffective respiratory drive and poor oxygenation.
Intravenous fluid resuscitation as indicated.
Manage raised intracranial pressure if suspected.
Special treatment depends on the underlying etiology of the unconsciousness.
Monitor the patients vital signs plus their urinary output through an inserted catheter.
18. Complications of unconsciousness
These can either depend on the underlying cause or duration of the unconscious state. Some of
these may include the following;
• Brain damage: prolonged unconsciousness can lead to brain damage due to lack of oxygen and
nutrients to the brain
• Deep vein thrombosis and pulmonary embolism due to prolonged immobility.
• Muscle atrophy: due to the disuse phenomenon where lack of movement/disuse of the muslces
leads to muscle wasting and weakness.
• Infections: unconscious patients have an increase of infections.
• Pressure sores particularly in areas where the body bears weight against a surface for an
extended period of time.
• Decubitus ulcers which can result from the pressure sores
• Aspiration pneumonia: due to the unconsciousness state and the inability of the person to
protect their own airway. Can inhale food, fluid or vomitus leading to aspiration pneumonia.
• Organ failure: unconsciousness can result in compromised functioning of the vital organs of the
body such as the heart, lungs, kidneys etc.
19. Prognosis of an unconscious patient
• Prognosis depends on a number of factors
• Non traumatic unconscious patient presenting with a stroke have the highest mortality while those
presenting with epilepsy and poisoning have the best prognosis.
• Patients with a lower GCS score at presentation i.e. of a 3-5, have a significantly higher mortality
than those with a higher GCS score(7-10).
• Patients not responding to initial treatment and who remain unconscious are likely to require
critical care admission unless withdrawal of treatment and palliation of symptoms is more
appropriate.
• Early communication with the next of kin, family or appropriate advocate is always necessary.
When the prognosis is poor, the discussions will include ceiling of care, consideration of future
withdrawal of treatment and cardiopulmonary resuscitation.
20. Conclusion
• The unconscious patient is challenging in terms of immediate care,
diagnosis, specific treatment and predicting prognosis.
• A systemic and logical approach is required with an emphasis on team work.
• Appropriate measures to resuscitate, stabilize and support an unconscious
patient must be performed rapidly.
• Decisions such as ceiling of care are required at an early stage in patients
with a poor prognosis.
Determining whether the pathology is structural or metabolic
Level of consciousness- arausability, GCS(eye opening, vocalisation, motor)
Motor responses
Brain stem reflexes
Cranial nerves