TRUECPA Group is formed by na interdisciplinary professional team of accountants, lawyers and specialists, trained in all the processes related to accounting, tax compliance, secretarial, payroll, business intermediation and tax consulting services.
TRUECPA Group is formed by na interdisciplinary professional team of accountants, lawyers and specialists, trained in all the processes related to accounting, tax compliance, secretarial, payroll, business intermediation and tax consulting services.
A evolução de terapias baseadas em corticosteroides para o tratamento da asmaThalles Peixoto
INTRODUÇÃO: A asma é uma patologia com grande impacto socioeconômico que afeta cerca de 300 milhões de pessoas no mundo, sendo que o Brasil se destaca negativamente como um dos 10 países com maiores índices de prevalência. Os corticosteroides são o tratamento de escolha para a maioria dos pacientes asmáticos, sendo recomendados atualmente por importantes diretrizes internacionais de manejo da patologia.
OBJETIVO: O objetivo do presente trabalho é revisar e analisar criticamente a literatura científica sobre a evolução do uso de corticosteroides no tratamento da asma, analisando o histórico de mudanças dessa classe terapêutica ao longo da cronologia médica e farmacêutica global, com intuito de inferir a viabilidade de novos tratamentos com tais moléculas nessa patologia.
MATERIAIS E MÉTODOS: Este trabalhou utilizou os principais guidelines de tra-tamento e manejo da asma e bases de dados como Pubmed/Medline, ISI Web of Knowledge e SCOPUS. A busca de palavras-chave como “asthma” e “corticoste-roids” foi cuidadosamente combinada com os termos “inhaler”, “metered-dose inhaler”, “hydrofluoroalkane”, “chlorofluorocarbon” e “epidemiology”, bem como esses termos em português. Os critérios de inclusão foram a data das publicações (1990 até 2012) e o idioma do artigo (inglês, português, espanhol ou italiano) e os de exclusão foram adotados para aqueles artigos cuja discussão da troca do propelente CFC para HFA fosse puramente ambiental ou artigos que trataram apenas de questões anatômicas da patologia.
RESULTADOS: Os estudos analisados mostram que os corticosteroides evoluíram consideravelmente desde seu primeiro uso no tratamento da asma, tanto em aspectos moleculares, nos seus dispositivos farmacotécnicos, na potência e segurança e em questões ligadas ao meio ambiente, dada a necessidade de um propelente para veiculação do fármaco. Nos últimos anos houve a descoberta de uma nova, e muito mais tecnológica, classe dessa família de moléculas, na forma de pró-fármacos (mais seguros dada sua ativação in situ), sendo a ciclesonida o principal exemplo dessa classe.
CONCLUSÃO: Novas terapias com corticosteroides para o tratamento da asma são possíveis e desejáveis, e podemos citar como prováveis próximos passos a melhoria da tecnologia de entrega do fármaco ao local de ação (hoje obtida pelos MDIs). Idealmente podemos chegar à perfeita terapia tópica com corticosteroides no tratamento da asma, no caso do advento de uma formulação com 100% de aproveitamento pul-monar e zero biodisponibilidade sistêmica, sendo essa uma importante lacuna a ser preenchida nessa patologia de grande prevalência e importância mundial.
Es necesario conocer los tiempos de Dios durante nuestra vida aquí en la tierra a fin de estar atentos a los acontecimientos propios de su venida lo que implica estar preparados para irnos con Él.
A evolução de terapias baseadas em corticosteroides para o tratamento da asmaThalles Peixoto
INTRODUÇÃO: A asma é uma patologia com grande impacto socioeconômico que afeta cerca de 300 milhões de pessoas no mundo, sendo que o Brasil se destaca negativamente como um dos 10 países com maiores índices de prevalência. Os corticosteroides são o tratamento de escolha para a maioria dos pacientes asmáticos, sendo recomendados atualmente por importantes diretrizes internacionais de manejo da patologia.
OBJETIVO: O objetivo do presente trabalho é revisar e analisar criticamente a literatura científica sobre a evolução do uso de corticosteroides no tratamento da asma, analisando o histórico de mudanças dessa classe terapêutica ao longo da cronologia médica e farmacêutica global, com intuito de inferir a viabilidade de novos tratamentos com tais moléculas nessa patologia.
MATERIAIS E MÉTODOS: Este trabalhou utilizou os principais guidelines de tra-tamento e manejo da asma e bases de dados como Pubmed/Medline, ISI Web of Knowledge e SCOPUS. A busca de palavras-chave como “asthma” e “corticoste-roids” foi cuidadosamente combinada com os termos “inhaler”, “metered-dose inhaler”, “hydrofluoroalkane”, “chlorofluorocarbon” e “epidemiology”, bem como esses termos em português. Os critérios de inclusão foram a data das publicações (1990 até 2012) e o idioma do artigo (inglês, português, espanhol ou italiano) e os de exclusão foram adotados para aqueles artigos cuja discussão da troca do propelente CFC para HFA fosse puramente ambiental ou artigos que trataram apenas de questões anatômicas da patologia.
RESULTADOS: Os estudos analisados mostram que os corticosteroides evoluíram consideravelmente desde seu primeiro uso no tratamento da asma, tanto em aspectos moleculares, nos seus dispositivos farmacotécnicos, na potência e segurança e em questões ligadas ao meio ambiente, dada a necessidade de um propelente para veiculação do fármaco. Nos últimos anos houve a descoberta de uma nova, e muito mais tecnológica, classe dessa família de moléculas, na forma de pró-fármacos (mais seguros dada sua ativação in situ), sendo a ciclesonida o principal exemplo dessa classe.
CONCLUSÃO: Novas terapias com corticosteroides para o tratamento da asma são possíveis e desejáveis, e podemos citar como prováveis próximos passos a melhoria da tecnologia de entrega do fármaco ao local de ação (hoje obtida pelos MDIs). Idealmente podemos chegar à perfeita terapia tópica com corticosteroides no tratamento da asma, no caso do advento de uma formulação com 100% de aproveitamento pul-monar e zero biodisponibilidade sistêmica, sendo essa uma importante lacuna a ser preenchida nessa patologia de grande prevalência e importância mundial.
Es necesario conocer los tiempos de Dios durante nuestra vida aquí en la tierra a fin de estar atentos a los acontecimientos propios de su venida lo que implica estar preparados para irnos con Él.
Grassi & Co. Manufacturing & Distribution Practice BrochureGrassi & Co.
The Manufacturing and Distribution (M&D) Industry faces unique challenges. During the last several decades, the dynamics of the domestic manufacturing and distribution market have shifted dramatically. The trend toward off-shore manufacturing requires manufacturers and distributors to be more nimble than ever to remain competitive. For more than 30 years, Grassi & Co.’s Manufacturing & Distribution Practice has specialized in serving this dynamic and challenging industry.
Bad debt recovery services revenue recovery solutions company prospectusrevenuerecovery
Revenue Recovery Solutions is a professional bad debt recovery agency. As bad debt collectors we are always mindful of future customer relationships and can request bad debt payment in a way that won’t offend or alienate your customers.
http://revenuerecoverysolutions.net/bad-debt-collection-services/
2. LIZGOENTERPRISES
For Private Investigations & Debt Collection Solutions
APPEDIX1
Lizgo Group IS A BRAND IN THE COLLECTION INDUSTRY.
We have branded our collection service that follows a strict code of ethics and performance standards. We
offer solutions to enable customers manage their credit responsibly. As a Brand we keep the promises we
have to our customers and principals which include:
1. UNDERSTANDING THE CUSTOMER
Lizgo Group has defined the debtor as its customer. As we commence the collection process, our role is to
make the customer pay our principals and continue to use our clients services if need arises. We start with
a benefit approach to ensure the customer understands why it is critical for them to pay the debt.
2. AN EFFECTIVE AND PROFESSIONAL COLLECTION PROCESS
We conduct our process with utmost professionalism. Our Team is firm, courteous and persuasive and
ensures that it negotiates the best terms that suits our principals.
3. RESULTS WITHIN A REASOANABLE SPEED OF SERVICE
LIZGO’S target Speed of Services (SOS) for collections is 60 calendar days, i.e. two months.The status of any
particular collection account at the end of 60 days should be at either of the following points.
i. Account fully paid
ii. Administration of a payment proposal ongoing
iii. Recovery through the court recommended
iv. Account placed in Debt Surveillance list.
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3. LIZGOENTERPRISES
For Private Investigations & Debt Collection Solutions
4. EMBRACING THE TEAM SPIRIT -ESCALATION RULES WITHIN THE 60 DAYS
You must understand that to work as a team Lizgo Group collectively seeks to achieve results within an
agreed time frame within our principals. Within the 60 days periods, certain decisions and actions must be
taken at particular point in order to guide the collection process. These key decision points are as follows.
i. By Day 7 the Ist demand letter must have been dispatched
ii. By Day 15 contact must been made with the debtor. If no contact has been made with debtor
and there is no acceptable explanation for these state affairs, the Team leader may withdraw
and allocate the debt to another collect.
iii. By Day 30, contact has been made but no payment or proposal has been received and the
debtor has not disputed the debt, the account will be withdrawn and allocated to another
collectors.
iv. By Day 45, contract has been established but no payment or proposal has been received, the
second and final demand letter be dispatched.
v. By Day 60, if no payment has been received or proposal administered, a recommended should
be made to send the matter to court or place the account on the surveillance list depending on
the strength of evidence available.
ii. By Day 15 contact must been made with the debtor. If no contact has been made
with debtor and there is no acceptable explanation for these state affairs, the Team
leader may withdraw and allocate the debt to another collect.
iii. By Day 30, contact has been made but no payment or proposal has been received
and the debtor has not disputed the debt, the account will be withdrawn and
allocated to another collectors.
iv. By Day 45, contract has been established but no payment or proposal has been
received, the second and final demand letter be dispatched.
v. By Day 60, if no payment has been received or proposal administered, a
recommended should be made to send the matter to court or place the account on the
surveillance list depending on the strength of evidence available.
Summary
Day 1 Day 15 Day 30 Day 45
Day 60
1. A PERFORMANCE MEASUREMENT INDEX
i. Lisgo uses metric called Debt collection Index (DCI) to measure the effectiveness of
Review Account
1st
Demand
Letter Sent
Contact made
With debtors
Proof of debt
Established
Re- allocate if
- No payment
- No proposal
2nd
demand if:
-No payment
- No proposal
Court or
surveillance if
-No payment
-No proposal
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4. LIZGOENTERPRISES
For Private Investigations & Debt Collection Solutions
1. A PERFORMANCE MEASUREMENT INDEX
i. Lisgo uses metric called Debt collection Index (DCI) to measure the effectiveness of collectors.
The DCI is calculated as follows.
Amount Collected
DCI- X 100
Total Allocated
ii. The DCI is used for two purposes:
a. To determine the effectiveness of a collector
b. To determine the overall effectiveness of the collection operation of the company
iii. Your target DCI will be 5% for the banking portfolio and 25% for theTrade and Utility portfolios
during your probation period. The company aims at an overall DCI of 40% across the entire
portfolio which must be achieved after confirmation, constituently low DCI of less than the target
acceptable and will result in automatic termination of collection services.
2. A PERFORMANCE MEASUREMENT INDEX
i) In order to be effective in undertaking your duties, you must have sufficient knowledge of the
customer’s business activities / income sources. This may include people close to him/ her that
would step in to remedy the situation you may need to tactfully access that these people and
persuade them to pay the debt on the debtor. NEVER USE THREATS.
ii) Your must employ good negotiation skills based on key attributes as:
√ Assertiveness
√ Persistence
√ Constituency and
√ Flexibility:
√ As well as the art of firm questioning and good listening.
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5. LIZGOENTERPRISES
For Private Investigations & Debt Collection Solutions
7. Commercial Collection
Commercial Collection services focus on companies and organizations with unpaid debtors from other
companies and organizations. (Business to Business)
Consumer Collection
Consumer Collection services are designed for companies with a customer base made up of many private
individuals, such as telephone, water and power companies. (Business to Consumers)
International Collection
In International Collection Lizgo Group has partnered with (DCP UK) and in reciprocal arrangements,
which call for Lizgo to collect debts, owed to clients of both companies in East Africa and for them (Thomas
Musau) to collect debts owed to our clients debts in other parts of the world including Europe, Asia and
the Americas.
Debt Surveillance
Under this service, Lizgo monitors long outstanding debts that may have been written off by companies
and attempts to collect them on the client’s behalf. Work on a portfolio usually continues for six years
before a debt is completely written off.
Tracing Services
In this service, Lizgo Group carries out investigations to trace debtors who the client has lost contact with.
This entails investigating the debtor’s location and assets to enable companies serve legal letters and
attach assets where judgment has been made.
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6. LIZGOENTERPRISES
For Private Investigations & Debt Collection Solutions
Benefits of using our debt recovery services include:
Fast payment
Customers normally pay faster once Lizgo intervenes with its status as a reliable corporate entity in Debt
Management.
Increased cash flow
Lizgo will accelerate the Collection process and thereby help eases your cash flow by reducing the amount
of debts you have;
Cost-effective
We operate a no collection, no commission policy;
Low commission charges
Our commission charges are very low and only charged on successful collection;
Nationwide service
No matter where your debt is we can help. We provide a nationwide debt collection service; International
collection capability. We will be able to collect your overseas debt through our affiliation with two
internationally renowned credit management services companies;
More time for you.
By letting us collect your debts, you have more time to spend running your business.
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7. LIZGOENTERPRISES
For Private Investigations & Debt Collection Solutions
Standard Individual Consumer Credit Report
Identification details:
• Name as appears on ID document
• Citizenship details
• ID numbers
• PIN number (alternate)
• Postal Address
• Telephone contacts
• Marital status
• Emails if available
• Credit history as reported
• Court judgment’s as reported
• Referees
Standard Individual Consumer Credit Report
Identification details:
• Name as appears on ID document
• Citizenship details
• ID numbers
• PIN number (alternate)
• Postal Address
• Telephone contacts
• Marital status
• Emails if available
• Credit history as reported
• Court judgment’s as reported
• Referees
8. CUSTOMIZED RATES
AMOUNT REGION
NAIROBI OUTSIDE NAIROBI
RATE
0-500,000 10% 15%
5M- 2M 2% 5%
2M – 5M 1% 2%
5M-10M 0.5% 1%
10M-20M 0.2% 0.5%
NOTE: All our commissions are subject to negotiations to suit the customer’s objections
where necessary within our mandate.
OUR CLIENTS
-ASSUP LTD
-THE STANDARD GROUP
-PROVIDENCE AFRICA
-NATION MEDIA
-METROTILE LTD
-RAVINA GROUP OF COMPANIES
We work in Consultation with Metropol E.A One of the leading Credit Reference Bureau
in East Africa.
Our Vision is to become Africa’s leading business information and debt Management
Company.
NOTE: All our commissions are subject to negotiations to suit the customer’s objections where necessary
within our mandate.
OUR CLIENTS
-ASSUP LTD
-THE STANDARD GROUP
-PROVIDENCE AFRICA
-NATION MEDIA
-METROTILE LTD
-RAVINA GROUP OF COMPANIES
We work in Consultation with Metropol E.A One of the leading Credit Reference Bureau in East Africa.
Our Vision is to become Africa’s leading business information and debt Management Company.
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8. For Private Investigations & Debt Collection Solutions
Hill View Rise Unit 12,
Lower Kabete Nairobi, Kenya.
P.O. Box 45123 - 00100 NAIROBI- KENYA
Tel: +254 722 336412/+254 786191557/+254 725 416222
Email: lizgogroup@gmail.com/info@lizgokenya.net
www.lizgokenya.net