This document summarizes a panel discussion on building an in-house eDiscovery program. The panelists represent various life science companies and discuss the pros and cons of bringing eDiscovery in-house versus using external vendors. They address key challenges around complexity, commitment, control, and cost. Building a successful in-house program requires assessing the complexity of cases and operations, securing long-term commitment of resources, maintaining control over the process while leveraging external expertise, and ensuring cost-effectiveness and budget sustainability. The panel provides advice on evaluating these factors and establishing a core team to efficiently manage eDiscovery internally.