This document discusses sex work and different policy approaches to regulating it. It defines sex work as the exchange of sexual services between consenting adults. There are over 1 million sex workers in the US generating $200 billion annually, with 14-20 million worldwide. Criminalization of sex work increases risks like HIV transmission and violence against workers. Decriminalization, removing criminal penalties, would decrease STIs/HIV and violence while increasing worker well-being and safety. Legalization through licensing/zoning could recreate an underground market with similar public health risks as criminalization. Decriminalization is identified as having the greatest impact on reducing HIV infections.