The document discusses lead poisoning, detailing its routes of exposure, organ systems affected, clinical symptoms, and sources of lead compounds. It emphasizes treatment options and outlines the medicolegal aspects of chronic lead poisoning as an industrial disease. Acute lead poisoning is rare, often resulting in recovery, while accidental poisoning can occur from unapproved medical uses.

1. Lead Poisoning

2. Route: Inhalation
Orally – Ingestion
Organ : skin & Mucous membrane
Capillaries & Arteries
Brain , Peripheral NS
. Encephalopathy .
Pathogenesis : Spasm of capillaries and Arteries
Sources: lead acetate/ oxide
. White lead, red lead (sindur) , white lead.

3. Fatal Dose: 0.5gm
. 20 gm
Organ Acute Chronic
Mouth
Tounge
GIT
Astringent Test
Dryness, Thirst,
Nausea, vomiting, colic
like pains (amle.
Pressure)
Encephalopathy
Headache
Paralysis
Trauma of eye
Lead line between Teeth
Colic and constipation

4. Organ Acute Chronic
Rectum
Stool
Offensiveness
Black
Obstinate constipation
Kidney
Decrease urination Arterial Degeneration
Nephritis
Leg Cramps Knee Inflammation,
Death Puncuate Basophilia
Paralysis

5. Treatment :
 Magnesium or sodium sulpate
 Morphine & Atropine
 EDTA & Penicillamine

6. Postmartum appearance
 Mucosa congested
 Eroded patches
 Large intestine may contain black colour feaces
 Bone marrow hyperplasia of erythroblast, leucoblast
decrease in fat cells.

7. Medicolegal aspect
Chronic lead poisoning is regarded as one of the industrial diseases.
Compounds of lead are poisonous
Acute lead poisoning is rare and the person is usually recovered.
Homicide by lead is rare because of taste.
 Accidental poisoning occurs by use of Litharge (Mudrasang) lead monoxide as
a remedy for syphilis by quacks.