How Japan cardiovascular therapy and medicine? Clinical output? at a glance

1. Japan cardiovascular market at a glance
Yuji Segawa All rights reserved
Yuji Segawa All Rights Reserved

2. Professional consultancy is provided through Guidepoint Global
Yuji Segawa All Rights Reserved

3. Trends of number of patient and diseased rate
0
500
1,000
1,500
2,000
2,500
1999 2002 2005 2008 2011
Ischemic cerebrovascular disease
Peripheral
Ischemic heart disease
0
50
100
150
200
250
300
350
1999 2002 2005 2008 2011
Ischemic cerebrovascular disease
Peripheral
Ischemic heart disease
# of patient
Thousands, each Oct.
Diseased rate
Per 100 thousand person
Source ; MHLW
• Number of patients are decreasing • Diseased rates are decreasing
Yuji Segawa All Rights Reserved

4. Trends of # of patients, detail data
1999 2002 2005 2008 2011
Ischemic heart disease
Angina pectoris 727 691 648 604 558
Acute myocardial infarction 82 51 41 49 41
Coronary artery sclerosis 20 9 6 5 5
Old myocardial infarction 96 81 105 89 110
Peripheral Peripheral embolism 18 18 14 12 15
Ischemic cerebrovascular
disease
Cerebral infarction 1,120 1,064 1,052 964 924
cerebral arteriosclerosis 28 11 6 6 13
Total 2,091 1,925 1,872 1,729 1,666
Source ; MHLW
# of patient Thousands, each Oct.
Yuji Segawa All Rights Reserved

5. Trends of diseased rate, detail data
1999 2002 2005 2008 2011
Ischemic heart disease
Angina pectoris 63 56 53 49 44
Acute myocardial infarction 10 7 7 7 6
Coronary artery sclerosis 2 1 0 0 0
Old myocardial infarction 8 6 8 7 8
Peripheral Peripheral embolism 3 2 2 2 2
Ischemic cerebrovascular
disease
Cerebral infarction 213 202 201 170 149
cerebral arteriosclerosis 4 2 1 1 1
Total 303 276 272 236 210
Source ; MHLW
Diseased rate Per 100 thousand person
Yuji Segawa All Rights Reserved

6. Trends of PCI
2009 2010 2011 2012 2013
Emergency PCI 59,234 64,333 67,207 68,749 68,254
Planned PCI 161,978 183,661 181,991 184,877 185,072
# of sample 1,524 1,646 1,676 1,612 1,535
Total PCI 221,212 247,994 249,198 253,626 253,326
PCI per one 145 151 149 157 165
PCI reaches out a peak
Source ; The Japanese circulation Society Yuji Segawa All Rights Reserved

7. Market volume trends; Anti-blood clot drugs; Million JPY, each Jul
antiplatelet+ Anticoagulant
0
1,000
2,000
3,000
4,000
5,000
6,000
7,000
1999 2002 2005 2008 2011 2013
Total GE
PlavixAspirin Complavin
EfientAnticoagulant
drug launch rush
Source ; MHLW, and Jiho Yuji Segawa All Rights Reserved

8. Trends of number of potential patient
1999 2002 2005 2008 2011
Insulin-independent diabetes mellitus 743 1109 1402 1250 1663
Hyperlipemia 1140 1391 1530 1433 1886
Depression 441 711 924 1041 958
Hyperpiesia 6979 6837 7693 7834 8986
Chronic Kidney failure 185 223 257 331 343
# patients are increasing
Source ; MHLW Yuji Segawa All Rights Reserved

9. KOL trends
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10. Detail therapeutic development and output
Professional consultancy is provided through Guidepoint Global
Yuji Segawa All Rights Reserved