The document discusses the relationship between allergic rhinitis and asthma and how they are united through epithelial cells. Epithelial cells represent the first barrier of the upper and lower respiratory tracts, making them a logical target for integrated therapeutic approaches. The review discusses how rhinosinusitis can be a co-morbid condition, precipitating/triggering condition, or epiphenomenon that is an integrated part of the overall disease. It calls for a better understanding and more pragmatic/cost-effective approaches to diagnosis and long-term management.

1. NIH FEDERAL GOVERNMENT SATANIC MANIFESTATIONS,
HELL ON EARTH,
NEWLY CREATED
COMBINED INFECTIOUS DISEASE VACCINE DISSEMINATION,
NAME ALIGNED, DEADLY, MORBID, FRAUDULENT,
UNACCOUNTABLE, LABORATORY CREATED INJECTION INDUCED,
REVERSAL OF GOOD, RACIST CONNOTATION, DEADLY
FRAUDULENT STUDY THAT ADVANCES THE DEMONIC
OBSTRUCTION OF HUMAN HEALTH
REVIEW SERIES
http://thorax.bmj.com/cgi/content/full/64/11/999
Upper airway · 1: Allergic rhinitis and
asthma: united disease through
epithelial cells
A Bourdin1, D Gras2, I Vachier1, P Chanez2
1
Department of Respiratory Disease , CHU Arnaud de
Villeneuve, Montpellier, France
2
Service de Pneumo-Allergologie et Laboratoire d’Immunologie, INSERM U 600,
Université de la Méditerranée, Marseille, France
Correspondence to:
Correspondence to
Professor P Chanez, Université de la Méditerranée, AP-HM, 270 Boulevard de
Sainte-Marguerite, F-13009 Marseille, France; pascal.chanez@univmed.fr
Received 11 May 2009
Accepted 14 June 2009
ABSTRACT

2. The relationship between allergic rhinitis and asthma is now
established, and most of the clinical, epidemiological and biological data
recommend integrated management. Epithelial cells represent the first barrier of
the upper and lower respiratory tracts and thus are logical targets
integrated therapeutic
for a comprehensive
approach. This review discusses rhinosinusitis as a co-
morbid condition , a precipitating or
triggering condition, and an epiphenomenon as an
integrated part of the disease. A better understanding and a more pragmatic
cost-
method of diagnosis and management is needed using
effective long-term
strategies.