Immune cell therapy of cancer
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Inmunoterapia Antitumoral Inmunologia Umsa
El documento resume los avances en inmunoterapia antitumoral. Explica que las terapias convencionales como quimioterapia y radioterapia han aumentado la supervivencia pero no curan los cánceres más comunes. La inmunoterapia es más prometedora porque explota las diferencias antigénicas entre células tumorales y normales. Se han logrado regresiones con citocinas, anticuerpos monoclonales y terapias celulares adoptivas. La investigación actual busca superar las limitaciones de especificidad y potencia de los
PRINCIPLES OF CANCER CHEMOTHERAPY
CANCER: A group of disease involving abnormal cell growth with the potential to invade or spread to other part of the body.
CHEMOTHERAPY: the term chemotherapy is describe as the use of chemicals or drugs to treat cancer.
CYTOTOXIC DRUG: lysis both normal and cancer cells
Chemotherapy
Chemotherapy uses antineoplastic drugs to destroy tumor cells by interfering with cell function and reproduction. It aims to kill cancer cells while minimizing harm to healthy cells. Chemotherapy is used as primary treatment for advanced cancer, as an adjuvant after surgery/radiation to prevent recurrence, and to palliate metastatic disease. Drugs target specific phases of the cell cycle and can be administered via various routes at doses based on body surface area. Nurses must monitor for predictable toxic effects on normal cells.
Basic principles of chemotherapy
Basic principles of chemotherapy/ AMAs covers definition, history of AMAs development, principles of AMAs, problems associated with AMAs, failure of therapy with examples.
Principles of chemotherapy ppt
Chemotherapy involves the use of cytotoxic drugs to treat cancer. The goals of chemotherapy are to cure cancer, improve survival rates, or relieve symptoms. Key principles of chemotherapy include: (1) using drug combinations to increase efficacy and decrease resistance, (2) treating micrometastatic disease early on, and (3) dose intensity being important for response. Adjuvant chemotherapy after surgery or radiation has improved survival rates for several cancers like breast cancer and osteosarcoma by targeting remaining micrometastatic disease.
cancer chemotherapy
Chemotherapy uses anti-cancer drugs to destroy cancer cells. It can be curative for some cancers like leukemias, Wilms tumor, and Hodgkin's lymphoma. The drugs work by interfering with cell division through different mechanisms and can be cell cycle specific or non-specific. Alkylating agents are a common class of chemotherapy drugs that work by transferring alkyl groups to DNA, causing cross-linkages and strand breaks to damage DNA and inhibit cell proliferation. Combination chemotherapy and intermittent dosing regimens are often used to improve outcomes.
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CANCER: A group of disease involving abnormal cell growth with the potential to invade or spread to other part of the body.
CHEMOTHERAPY: the term chemotherapy is describe as the use of chemicals or drugs to treat cancer.
CYTOTOXIC DRUG: lysis both normal and cancer cells
Chemotherapy
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Basic principles of chemotherapy
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Principles of chemotherapy ppt
Chemotherapy involves the use of cytotoxic drugs to treat cancer. The goals of chemotherapy are to cure cancer, improve survival rates, or relieve symptoms. Key principles of chemotherapy include: (1) using drug combinations to increase efficacy and decrease resistance, (2) treating micrometastatic disease early on, and (3) dose intensity being important for response. Adjuvant chemotherapy after surgery or radiation has improved survival rates for several cancers like breast cancer and osteosarcoma by targeting remaining micrometastatic disease.
cancer chemotherapy
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1) A 20-month-old boy developed severe aplastic anemia after receiving a liver transplant for unknown fulminant hepatic failure.
2) He was treated with an autologous cord blood transplant using the cord blood that had been stored at his birth.
3) He had a successful engraftment and remains in remission 3 years later, demonstrating autologous cord blood transplantation can treat severe aplastic anemia in rare cases.
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1) NK cells expanded over 4,000-fold when co-cultured with irradiated lymphoblastoid cells over 21 days.
2) The expanded NK cells had increased expression of activating receptors like TRAIL, FasL, and NKG2D compared to resting NK cells.
3) The expanded NK cells showed significantly higher cytotoxicity against tumor cells treated with bortezomib compared to resting NK cells.
4) The expanded NK cells secreted higher levels of cytokines like IFN-γ when co-c
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