Comprehensive lecture about IgG4 disease

2. PROF DR
Abdel Rahman Abdel Hai Moukhtar
Internal Medicine @ Mansoura University
Consultant Internist @ NWAFH – Tabuk - KSA

5. Definition
(IgG4-RD) is an increasingly recognized
Immune-mediated
*chronic relapsing–remitting *fibro-inflammatory * infiltrative condition
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7. And the
list is still
growing

8. Several major points should be drawn from contrasting studies

12. ‫الحصيره‬

13. The Big Debate

15.  Potential Triggers
 Specific Disease Pathways
 Cellular response

16. Potential Triggers

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20. what is wrong ?

23. (Van der Neut Kolfschoten et al,
2007).

24. Fab-arm exchange

25. The Unique IgG4

27. 1
2
3
4

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32. The slowly evolving nature of IgG4- RD is one of its
characteristic features:

37. Gastroenterologists:
Ophthalmologists:
Nephrologists :
Rheumatologists:
Pulmonologist :

40. 

41. Epidemiology

43. SEX distribution :
AGE distribution :

45. Diagnosis

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51. The 2019 American College of Rheumatology/European
League Against Rheumatism classification criteria for IgG4-
related disease.
The 2020 revised comprehensive diagnostic (RCD) criteria
for IgG4-RD :

53. The 2019 American College of Rheumatology/European League
Against Rheumatism classification criteria for IgG4-related
disease.
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54. ‫مرحلة‬
‫االشتباه‬(Entery
Criteria )

55. Criteria) ‫المرحله‬
‫مرحلة‬ ‫الثانيه‬
‫االستبعاد‬

56. ‫المرحله‬
‫الثالثه‬
‫مرحلة‬
‫االعتماد‬
(Total Inclusion score )
A case meets the classification
criteria for IgG4-RD if the entry
criteria are met, no exclusion criteria
are present, and the total inclusion
points is ≥20.

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61. The 2019 classification criteria for IgG4-related disease
A Note For the clinician
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66. To Conclude :
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