Webinar Presentation Syndromic Testing – A New Take on Diagnosing Infectious Diseases
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Webinar Presentation Syndromic Testing – A New Take on Diagnosing Infectious Diseases
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Webinar Presentation Syndromic Testing – A New Take on Diagnosing Infectious Diseases
- 1. Syndromic Testing – A New Take on Diagnosing Infectious Diseases Emerging Tech Webinar September 2023
- 2. 2 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Moderator and Speakers www.bisresearch.com Bruno Miguel Taveira Vaz Country Lead BD Amr Farid Business Development LabCorp Prateeksha Singh Lead Analyst BIS Research Inc. (Moderator) Riya Gupta Research Analyst BIS Research Inc.
- 3. 3 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Agenda www.bisresearch.com Introduction New Standard of Care in the Treatment of Infectious Diseases and Syndromic Testing Major Factors Driving the Growth of the Syndromic Testing Market Syndromic Testing Market Growth Major Players in the Syndromic Testing Market Ecosystem Opportunities of Syndromic Testing Q&A Session Use of NGS Metagenomics in Acute Care Syndromic Testing
- 4. Bruno Miguel Taveira Vaz Country Lead BD Key Speaker
- 5. Syndromic diagnostic testing - new standard of care in the treatment of infectious diseases
- 6. Disclosure
- 7. Agenda
- 8. The need
- 9. The need LABORATORY DIAGNOSIS HISTORIC ALLY PERFORMED USING A “MIXED B AG ” APPROACH
- 10. Laboratory diagnosis GASTROENTERITIS Rapid testing is vital Appropriate treatment for critical patients Prevent the spread of gastroenteritis through isolation measures
- 11. Laboratory diagnosis GASTROENTERITIS Conventional diagnostics techniques Culture Antigen detection Microscopy Multiple steps Up to 3 days for result
- 12. Laboratory diagnosis GASTROENTERITIS Additional testing Gram staining Catalase Hippurate Incubation 42 ºC 37 ºC Microaerophilic 48 h Culture Skirrow, Butzler, Preston CCDA Methylene blue stool staining Sensitivity Specificity Campylobacter spp. isolation
- 13. What if we could simplify infectious diseases testing with….. Results up to 3 h or less? Reduced hands- on time? Greater sensitivity and specificity? Flexibility for a targeted diagnosis?
- 14. The Solutions
- 15. The Solutions Advances in molecular diagnostics allow for a targeted diagnosis of infectious diseases Better Clinical Performance Direct Pathogen Detection Reduced Hands-on Time Reduced Time To Detection
- 16. The Proposals
- 17. The Proposals
- 18. The Value
- 20. The value C ASE #1
- 21. The value C ASE #1, CONTINUED
- 22. The value SYNDROMIC PANELS: ADVANTAGES SYNDROMIC PANELS: LIMITATIONS
- 23. Summary
- 24. References
- 27. Empowering Healthcare: Metagenomics NGS in Acute Syndromic Testing
- 28. Objectives: - Overview - Infectious Diseases Diagnostics - Metagenomics Next Generation Sequencing (mNGS) - Key Applications & Implementing of Clinical (mNGS) - Summary
- 29. Overview: - Infectious diseases are caused by pathogenic microorganisms, such as bacteria, viruses, parasites, or fungi; the diseases can be spread, directly or indirectly, from one person to another.
- 30. Infectious Diseases Diagnostics: - The global burden of antimicrobial resistance continues to rise.1 - 5 Priority bacterial pathogens account for >70% of the AMR deaths - The judicious use of antimicrobials is of utmost importance. - Novel unknown Infections and mutation, outbreaks. 1.Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022 Feb 12;399(10325):629-655. doi: 10.1016/S0140- 6736(21)02724-0. Epub 2022 Jan 19. Erratum in: Lancet. 2022 Oct 1;400(10358):1102. PMID: 35065702; PMCID: PMC8841637.
- 31. Infectious Diseases Diagnostics: A major threat to global health - Drug-resistant infections affect the lives of billions worldwide.2 2.Ramanan Laxminarayan et al. Access to effective antimicrobials: a worldwide challenge. Lancet. 2016; 387: 168-175 / https://www.reactgroup.org/news-and-views/news-and-opinions/year2020/new-react-film- children-at-risk-the-threat-of-antibiotic-resistance/; 2. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet 2022 https://www.sciencedirect.com/science/article/pii/S0140673621027240?via%3Dihub; 3. https://www.worldbank.org/en/topic/health/publication/drug-resistant-infections-a-threat-to-our-economic-future
- 32. Infectious Diseases Diagnostics Methods: - Current diagnostic methods: - One at a time or multiple known pathogens.
- 33. What is Metagenomics Next Generation Sequencing: - Metagenomics (mNGS) is the discipline that refers to the sequencing of all nucleic acid material present within specimen to recover clinically relevant microbial information.
- 34. What is Metagenomics Next Generation Sequencing: Historical overview 3.Metagenomics timeline and milestones. Timeline showing advances in microbial communities studies from Leeuwenhoek to NGS (Ottman et al., 2012; Yarza et al., 2014).
- 35. What is Metagenomics Next Generation Sequencing (Types): - Targeted amplicons rRNA 16S - Shotgun sequencing The reference: "3.Chiu CY, Miller SA. Clinical metagenomics. Nat Rev Genet. 2019 Jun;20(6):341-355. doi: 10.1038/s41576- 019-0113-7. PMID: 30918369; PMCID: PMC6858796."
- 36. Key Applications & Implementing of Clinical (mNGS) - General Application - Clinical Diagnostics - Epidemiology - Animal Health - Food Safety - Drug discovery - Environmental
- 37. Key Applications & Implementing of Clinical (mNGS) - Clinical application: - Screening and discovery of novel genes/enzymes - New species discovery - Pathogen Dx - Pharmacogenomics - Antibiotic resistance
- 38. Key Applications & Implementing of Clinical (mNGS) - To implement NGS in routine diagnostics, several adjustments in the laboratory workflows are required. 1- The wet laboratory (nucleic acid extraction, library preparation, sequencing) 2- The bioinformatics (analyses of the sequence data and translating them into easy to understand reports)
- 39. Summary - Metagenomics has broad applications in various industries. - We anticipate that the use of mNGS in medical microbiology laboratories will further increase over the next few years, for the characterisation and surveillance of pathogens, the investigation of outbreaks, infection prevention and the detection of novel resistance genes. - Whole Genome Shotgun Sequencing is a powerful tool to study microbiome and understanding host- pathogen interactions.
- 40. References: - Dumkow LE, Worden LJ, Rao SN. Syndromic diagnostic testing: a new way to approach patient care in the treatment of infectious diseases. J Antimicrob Chemother. 2021 Sep 23;76(Suppl 3):iii4-iii11. doi: 10.1093/jac/dkab245. PMID: 34555157; PMCID: PMC8460095. - Antimicrobial Resistance Collaborators. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022 Feb 12;399(10325):629-655. doi: 10.1016/S0140- 6736(21)02724-0. Epub 2022 Jan 19. Erratum in: Lancet. 2022 Oct 1;400(10358):1102. PMID: 35065702; PMCID: PMC8841637. - Metagenomics timeline and milestones. Timeline showing advances in microbial communities studies from Leeuwenhoek to NGS (Ottman et al., 2012; Yarza et al., 2014). - Chiu CY, Miller SA. Clinical metagenomics. Nat Rev Genet. 2019 Jun;20(6):341-355. doi: 10.1038/s41576-019-0113-7. PMID: 30918369; PMCID: PMC6858796.
- 41. Riya Gupta Research Analyst BIS Research Inc. Key Speaker
- 42. Syndromic Testing: Trends and Key Market Developments
- 43. 43 Syndromic Testing – A New Take on Diagnosing Infectious Diseases 1.28 1.51 1.94 3.25 2022 2024 2027 2033 $Billion North America Europe Asia Pacific Latin America CAGR (2023-2033): 9.43% Regional Market Landscape Current market adoption rates across regions indicate a high-growth market www.bisresearch.com Source: BIS Research Analysis Source: BIS Research Analysis North America Europe Asia Pacific Latin America Rest of the World 0.00% 40.00% 80.00% 0.00% 7.00% 14.00%
- 44. 44 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Testing Landscape Syndromic Tests Available for Various Disease Types www.bisresearch.com 56.29% 20.65% 15.89% 4.58% 2.59% 2022 Respiratory Diseases Gastrointestinal Diseases Genitourinary Diseases Tropical Diseases Others 56.20% 22.87% 11.98% 4.15% 4.80% 2033 Source: BIS Research Analysis As of 2022, the global acute care syndromic testing market (by disease type) was dominated by the respiratory diseases segment, holding a 56.29% market share. Additionally, the revenue of the respiratory diseases segment is anticipated to increase to $4.74 billion by 2033, holding a 56.20% market share in 2033. Infectious diseases are of many types and can most easily be sorted by the type of disease they cause. Over the last few decades with the advent of numerous outbreaks such as the Spanish Flu in 1918, SARS in 2002, and lately the advent of COVID-19 in 2019, the world has witnessed many medical achievements, and due to this, most infectious diseases are now curable. However, there are still numerous infectious diseases left that still do not have a cure and thus are a great burden to the economy. Other Diseases include central nervous system-based infections, such as those caused by meningitis and encephalitis, and blood culture-based infections, such as sepsis.
- 45. 45 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Market Shares > 6% Market Shares in the Range of 4%-6% Market Shares < 4% Leading Players in the Market The market is dominated by big players www.bisresearch.com Source: BIS Research Analysis
- 47. 47 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Factors Propelling the Demand for Syndromic Testing The Rising Population and Global Temperature are the Key Catalysts for the Increase of Infectious Diseases www.bisresearch.com Increasing Incidence of Infectious Diseases Early Diagnosis with Syndromic Testing Reduced Use of Antibiotics because of Syndromic Testing +2 Bn World population has been steadily rising and is further expected to increase by nearly 2 billion people in the next 30 years 30% It is estimated that antibiotic resistance caused 4.95 million deaths in 2019. antibiotic prescriptions could be reduced by 30% with the use of syndromic testing ~$3,000 According to BioFire Diagnostics, using syndromic testing panels can save hospitals expenses by about $3,000 per patient in overall hospital costs for sepsis alone
- 48. 48 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Opportunities of Syndromic Testing Decreasing Time of Diagnosis Leads to Lower Symptoms and Lower Use of Antibiotics www.bisresearch.com Reduction in Antibiotics Use with Syndromic Testing Time of Diagnosis vs. Disease Effect 13% Reduction in Antibiotic Therapy Duration 30% Reduction in Antibiotic Prescriptions A Fewer Day in the Median Antimicrobial Duration in Adult Influenza Patients Source: BIS Research Analysis Source: QIAGEN N.V. Company Website Time of Diagnosis with Single Plex Panels Onset of Symptoms Time of Diagnosis with Syndromic Panels Early Intervention After Symptoms Disease Effect Time of Diagnosis
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- 50. 50 Syndromic Testing – A New Take on Diagnosing Infectious Diseases www.bisresearch.com Insight Monk ▪ Over 1,000+ healthcare industry market intelligence reports ▪ Access to PDFs from over 100,000 reputed sources ▪ Market Statistics ▪ Company profiles for leading and emerging companies in the healthcare industry ▪ Database of key industry professionals ▪ Expert content like analyst notes, whitepapers ▪ Global expert network for consultations To get a free trial access, please schedule a demo. Visit: https://www.insightmonk.com/
- 51. 51 Syndromic Testing – A New Take on Diagnosing Infectious Diseases Syndromic Testing – A New Take on Diagnosing Infectious Diseases Speaker Contact Information Bruno Miguel Taveira Vaz Reach out to him at brunotaveira@hotmail.com Amr Farid Reach out to him at amr.alawi.a@gmail.com www.bisresearch.com
- 52. 52 Syndromic Testing – A New Take on Diagnosing Infectious Diseases THANK YOU BIS RESEARCH INC. 39111 Paseo Padre Pkwy STE 313, Fremont CA 94538-1686, USA Tel: +1-510-404-8135 U.K. Office Dns House 382 Kenton Road, Harrow, Greater London, United Kingdom, HA3 8DP Tel: +44-2039666162 India Office Tapasya Corporate Heights, Greater Noida Expressway, Sector 126, Noida, U.P., 201303 India Tel: +91 120 4261540 www.bisresearch.com