CARDIOLOGY CHORNICLES

1. Protocol #
Date of the IEC SKIMS meeting:
Details of the Applicant
Name: Dr. Sameer Purra
Designation: DM Scholar
Department: Cardiology
Phone: 6005537883
Email: purrawaris@gmail.com

2. Protocol #
Details of the P.I. /Supervisor / Guide
Name: Prof. ( Dr.) Hilal Ahmad Rather
Qualification: MBBS. MD. DM. FESC. FACC
Designation: PROF AND HEAD
Department: CARDIOLOGY
Phone: 9419009443
Email: hodcardiologyskims109@gmail.com
Number of ongoing studies:
(where PI is involved)

3. Protocol #
Details of the CO-investigator(s) /Co-Supervisor(s) / Co-Guide(s)
Co-investigator #1 #2 #3
Name: Dr. Aamir Rashid Lt Col (Dr) SS
Shekhawat
Dr. Sameer
Purra
Qualification: MD, DM MD MD
Designation: Associate
professor
Assistant
Professor
DM
RESIDENT
Department: Cardiology Internal
Medicine
Cardiology
Phone: 9419330159 8778836991 6005537883
Email: aamirrashid11@ya
hoo.com
rananjay164
@gmail.com
purrawaris@
gmail.com

4. Protocol #
Title of the Project/study:
 CLINICAL AND ANGIOGRAPHIC PROFILE OF ARMED FORCE PERSONNEL
PRESENTING AS ACS AT A TERTIARY CARE INSTITUTE IN JAMMU AND
KASHMIR
Site(s) where study is to be conducted:
SKIMS SOURA

5. Research Question ?
/Hpothesis
Primary Objectives:
 To assess the clinical and angiographic profile of armed force personnel
presenting as acute coronary syndrome at our center
Secondary Objectives:
 To correlate various demographic, clinical and biochemical variables with
the burden of coronary artery disease in this population group.
 To ascertain the clinical outcome which includes mortality and impairment
of quality of life at 7 and 30 days post event.
 To ascertain the incidence and prevalence of ACS amongst different
groups of armed force personnel including Regular Army, CRPF (central
reserved police forces), BSF (border security forces) and acknowledge any
differences whatsoever
 To correlate various stress factors using a validated stress questionnaire

6. Protocol #
 Total estimated budget: NIL
 Agency / Sponsor: NONE
 Conflict of interest, if any: NONE
 Duration of the Project (months): 24 MONTHS
 Suggested date of starting the study: SEP 2022
 Total number of patients to be accrued
◦ From SKIMS: 50 Total: 50
 Will biological products be sent out of:
◦ SKIMS: X Country: X

7. Sample Size
 No. of subjects:
64
 Controls: 64
 Calculation method
used: two-sample
t-test
 Power 0.8

8. Selection criteria
Inclusion Criteria:
 All armed force personnel
admitted with the diagnosis
of acute coronary
syndrome which includes
STEMI, NSTEMI and
Unstable angina will be
eligible for inclusion in the
study.
Exclusion Criteria:
 Patients presenting as
chronic stable angina
 Patients with severe
renal insufficiency
defined as creatinine
clearance < 30
Does the study involve vulnerable groups: NONE
(Women / Children / Ethnic / others )

9. Outcome measures
Clinical:
 History : time of onset of pain,
time of reporting to hospital, time
of receiving reperfusion therapy
and type of reperfusion therapy.
 Demographic details
 Conventional atherosclerotic risk
factors (smoking, hypertension,
diabetes mellitus, or
dyslipidemia) will be identified
and documented in each patient.
 Stress questionnaire will be
conducted on each patient post
recovery and subjects will be
provided with a particular score.
Lab parameters:
1. Angiographic characteristics :
site, severity, type and extent of
lesions; and number of vessels
involved
2. Routine investigations like
random blood sugar, complete
blood count, blood urea, serum
creatinine along with other
investigations like lipid profile
and cardiac specific enzymes
3. Echocardiography will be done
in all patients to detect the wall
motion abnormalities and to
assess the left ventricular
function, in addition to noticing
LV dimensions and evidence of
any mechanical complications.
Echo will be performed at
baseline and at 6 weeks to

10. Benefits of the Project / Study
To SKIMS:
 This is the first study from
Jammu and Kashmir
conducted to explore the
clinical profile of these patients
with CAD undergoing per-
cutaneous revascularization in
terms of risk factors, clinical
presentation, and angiographic
characteristics; and to analyze
procedural outcomes at our
hospital.
 To generate baseline regional
data and compare it to various
national and international data
available.
To Study Subjects:
1. Cardiovascular risk factors
have potentially devastating
consequences on the
combat readiness of the
military.
2. Expedited medical care with
timely reperfusion and a
robust follow up to tackle
complIcat-ions.