This document provides an overview of the I-Corps program at the National Institutes of Health (NIH). It discusses the goals of the program, which are to help scientists move ideas out of the lab and into the marketplace by teaching entrepreneurial skills like customer development. The summary discusses that over 57 teams have conducted over 6,300 customer interviews through the program. It also provides an example of a team that was able to pivot their focus based on customer feedback during I-Corps.
O documento apresenta vários trechos literários e regras para escrita. As informações essenciais são: 1) Há citações de obras literárias e listas de regras para criação de histórias; 2) Uma lista apresenta 10 regras para escrita de Elmore Leonard; 3) Os trechos literários ilustram diferentes estilos e temas incluindo ficção, memórias e conselhos para escritores.
Los alumnos de 4o primaria realizaron una excursión el 12 de noviembre de 2010. Visitaron diferentes lugares y disfrutaron de actividades al aire libre. Fue una experiencia educativa y divertida para los niños.
UNIP 4 Semestre -Np1 Complementos de Fisisca1diasf2003
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UNIP 4 Semestre - Provas
Fenomenos de Transportes, Complementos de Fisisca, Dinamica dos solidos, Estatistica Indutiva, Equaçoes Diferenciais, Engenharia de Meio Ambiente, Programação de Computadores
Este estudo avaliou a influência de complicações maternas, parâmetros fetais e condições neonatais nos diferentes graus de corioamnionite. Os resultados mostraram que os graus mais elevados de corioamnionite foram observados em casos com intercorrências maternas. Houve correlações negativas significativas entre os parâmetros fetais como peso e comprimento e o grau de corioamnionite.
El documento describe un cuestionario sobre cableado estructurado. Incluye preguntas sobre la definiciĂłn de un sistema de cableado estructurado, sus ventajas y desventajas en comparaciĂłn con un cableado tradicional, y componentes clave como el cableado horizontal, vertical, y el cuarto de telecomunicaciones.
O documento apresenta vários trechos literários e regras para escrita. As informações essenciais são: 1) Há citações de obras literárias e listas de regras para criação de histórias; 2) Uma lista apresenta 10 regras para escrita de Elmore Leonard; 3) Os trechos literários ilustram diferentes estilos e temas incluindo ficção, memórias e conselhos para escritores.
Los alumnos de 4o primaria realizaron una excursión el 12 de noviembre de 2010. Visitaron diferentes lugares y disfrutaron de actividades al aire libre. Fue una experiencia educativa y divertida para los niños.
UNIP 4 Semestre -Np1 Complementos de Fisisca1diasf2003
Â
UNIP 4 Semestre - Provas
Fenomenos de Transportes, Complementos de Fisisca, Dinamica dos solidos, Estatistica Indutiva, Equaçoes Diferenciais, Engenharia de Meio Ambiente, Programação de Computadores
Este estudo avaliou a influência de complicações maternas, parâmetros fetais e condições neonatais nos diferentes graus de corioamnionite. Os resultados mostraram que os graus mais elevados de corioamnionite foram observados em casos com intercorrências maternas. Houve correlações negativas significativas entre os parâmetros fetais como peso e comprimento e o grau de corioamnionite.
El documento describe un cuestionario sobre cableado estructurado. Incluye preguntas sobre la definiciĂłn de un sistema de cableado estructurado, sus ventajas y desventajas en comparaciĂłn con un cableado tradicional, y componentes clave como el cableado horizontal, vertical, y el cuarto de telecomunicaciones.
El documento habla sobre la Jornada Mundial de la Juventud que se celebra anualmente en cada diĂłcesis el Domingo de Ramos y cada dos o tres años se realiza un gran encuentro internacional presidido por el Papa. Este año el encuentro internacional será del 15 al 22 de agosto en la villa medieval española situada entre los rĂos Duero y DuratĂłn donde se encuentra el convento de San Juan y Pablo del siglo XIII.
Los alumnos de 7o grado de la escuela primaria pasaron un dĂa juntos realizando actividades recreativas y educativas fuera del aula. Dos estudiantes, Agustina Manfredi y Pilar Meynet, organizaron y llevaron a cabo las actividades del dĂa para sus compañeros.
El documento presenta las respuestas a un cuestionario sobre cableado estructurado realizado por un estudiante. Define un sistema de cableado estructurado como una plataforma capaz de integrar servicios de telecomunicaciones como telefonĂa, video y datos. Detalla las ventajas de este sistema, incluyendo su flexibilidad y capacidad para soportar diferentes tipos de cable, asĂ como sus desventajas como la dificultad en localizar averĂas. Explica conceptos como el cableado horizontal, vertical y el cuarto de telecomunicaciones. Finalmente, enumera las
UNIP 4 Semestre -Np2 Complementos de Fisiscadiasf2003
Â
UNIP 4 Semestre - Provas
Fenomenos de Transportes, Complementos de Fisisca, Dinamica dos solidos, Estatistica Indutiva, Equaçoes Diferenciais, Engenharia de Meio Ambiente, Programação de Computadores
La sociedad de la informaciĂłn se caracteriza por la capacidad de sus miembros para crear, obtener, distribuir, compartir y manipular informaciĂłn instantáneamente desde cualquier lugar. Esto trae consigo la globalizaciĂłn, nuevos sectores laborales, un ritmo de cambio acelerado y la necesidad de que las instituciones educativas se vuelvan más flexibles y adapten sus currĂculos y estructuras a las nuevas tecnologĂas.
La tecnologĂa ayuda a mejorar la calidad de vida de la sociedad al permitir que las industrias innoven y resuelvan problemas de manera más eficiente, con menores costos, errores y riesgos, y mayor calidad y producciĂłn. Además, la tecnologĂa ha transformado el mundo de una forma más sencilla e inclusiva y ha mejorado la vida de personas con discapacidades. Se espera que la tecnologĂa continĂşe usándose para beneficiar a la sociedad.
As crianças da escola primária prepararam espetadas de frutas cortadas em pedaços e as encontraram muito saborosas. Eles registraram seu trabalho e apreciação pelas frutas preparadas.
Acordo ortográfico da LĂngua Portuguesa / Nova Ortografia da LĂngua PortuguesaMarcelo Spalding
Â
O documento discute as principais mudanças trazidas pelo Acordo Ortográfico da LĂngua Portuguesa de 1990, incluindo a remoção do acento em certas palavras paroxĂtonas, mudanças na acentuação de palavras como "assembleia" e regras revisadas para o uso do hĂfen em palavras compostas.
El software envĂa instrucciones al hardware para generar las operaciones de la máquina, permitiendo la interacciĂłn entre el software y el hardware que hace posible el funcionamiento del equipo.
El documento resume un estudio sobre las relaciones entre la percepciĂłn del clima motivacional de los padres y la motivaciĂłn autodeterminada en jĂłvenes deportistas. El estudio examinĂł 97 jugadores de fĂştbol entre 12 y 16 años para analizar cĂłmo el clima motivacional percibido de sus padres se relacionaba con sus niveles de motivaciĂłn autodeterminada. Los resultados mostraron que los padres tenĂan una gran implicaciĂłn e influencia en los comportamientos de los jugadores.
This document provides a student research proposal for a project studying adult hippocampal neurogenesis across primate species, including humans. The student aims to quantify and compare the presence of new neurons in the dentate gyrus of various primates to test the hypothesis that humans have greater neurogenesis which could allow for unique episodic memory abilities. The student has experience in neuroanatomy research and aims to continue the project to gain skills relevant to future career goals investigating memory and neurolaw.
O documento discute conceitos de biologia evolutiva como a origem e relações entre organismos, mecanismos de isolamento reprodutivo e os conceitos de homologia, convergência evolutiva e adaptação.
UNIP 4 Semestre -Np2 Fenomenos de Transportesdiasf2003
Â
O documento apresenta três problemas de fenômenos de transporte envolvendo bombas, tubulações e instalações hidráulicas. O primeiro problema descreve uma instalação com bomba de 4cv e 65% de rendimento e pede para calcular velocidades, pressões e altura da caixa d'água. O segundo problema pede para determinar a potência e tipo de máquina em uma instalação com vazão de 62,8 L/s. O terceiro problema pede para determinar a direção e velocidade de um pistão em um circuito hidráulico.
Students in Public Health programs are expected to use the best available research evidence in coursework, practicum placements and upon entry into the public health workforce. This webinar will feature an overview of the process for evidence-informed public health and a model for evidence-informed decision making. Learn more about valuable online resources from the National Collaborating Centre for Methods and Tools (NCCMT) that can help you become skilled in finding and using the best available research evidence and developing the core competencies for public health.
A panel of current MPH students and MPH alumni from various programs across the country will share their experiences of using research evidence in coursework and their public health careers.
The National Collaborating Centre for Methods and Tools is funded by the Public Health Agency of Canada and affiliated with McMaster University. The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.
NCCMT is one of six National Collaborating Centres (NCCs) for Public Health. The Centres promote and improve the use of scientific research and other knowledge to strengthen public health practices and policies in Canada.
K99/R00 Awards - Pathways to IndependenceUCLA CTSI
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Dr. Evans provides considerations in applying for a K99 Award. Provided by the UCLA Clinical and Translational Science Institute. More information at https://ctsi.ucla.edu/education/pages/edtools and https://ctsi.ucla.edu/education/pages/kprogram
Presenter:
Christopher Evans, PhD
Professor of Psychiatry and Biobehavioral Sciences at UCLA
Director, Brain Research Institute
El documento habla sobre la Jornada Mundial de la Juventud que se celebra anualmente en cada diĂłcesis el Domingo de Ramos y cada dos o tres años se realiza un gran encuentro internacional presidido por el Papa. Este año el encuentro internacional será del 15 al 22 de agosto en la villa medieval española situada entre los rĂos Duero y DuratĂłn donde se encuentra el convento de San Juan y Pablo del siglo XIII.
Los alumnos de 7o grado de la escuela primaria pasaron un dĂa juntos realizando actividades recreativas y educativas fuera del aula. Dos estudiantes, Agustina Manfredi y Pilar Meynet, organizaron y llevaron a cabo las actividades del dĂa para sus compañeros.
El documento presenta las respuestas a un cuestionario sobre cableado estructurado realizado por un estudiante. Define un sistema de cableado estructurado como una plataforma capaz de integrar servicios de telecomunicaciones como telefonĂa, video y datos. Detalla las ventajas de este sistema, incluyendo su flexibilidad y capacidad para soportar diferentes tipos de cable, asĂ como sus desventajas como la dificultad en localizar averĂas. Explica conceptos como el cableado horizontal, vertical y el cuarto de telecomunicaciones. Finalmente, enumera las
UNIP 4 Semestre -Np2 Complementos de Fisiscadiasf2003
Â
UNIP 4 Semestre - Provas
Fenomenos de Transportes, Complementos de Fisisca, Dinamica dos solidos, Estatistica Indutiva, Equaçoes Diferenciais, Engenharia de Meio Ambiente, Programação de Computadores
La sociedad de la informaciĂłn se caracteriza por la capacidad de sus miembros para crear, obtener, distribuir, compartir y manipular informaciĂłn instantáneamente desde cualquier lugar. Esto trae consigo la globalizaciĂłn, nuevos sectores laborales, un ritmo de cambio acelerado y la necesidad de que las instituciones educativas se vuelvan más flexibles y adapten sus currĂculos y estructuras a las nuevas tecnologĂas.
La tecnologĂa ayuda a mejorar la calidad de vida de la sociedad al permitir que las industrias innoven y resuelvan problemas de manera más eficiente, con menores costos, errores y riesgos, y mayor calidad y producciĂłn. Además, la tecnologĂa ha transformado el mundo de una forma más sencilla e inclusiva y ha mejorado la vida de personas con discapacidades. Se espera que la tecnologĂa continĂşe usándose para beneficiar a la sociedad.
As crianças da escola primária prepararam espetadas de frutas cortadas em pedaços e as encontraram muito saborosas. Eles registraram seu trabalho e apreciação pelas frutas preparadas.
Acordo ortográfico da LĂngua Portuguesa / Nova Ortografia da LĂngua PortuguesaMarcelo Spalding
Â
O documento discute as principais mudanças trazidas pelo Acordo Ortográfico da LĂngua Portuguesa de 1990, incluindo a remoção do acento em certas palavras paroxĂtonas, mudanças na acentuação de palavras como "assembleia" e regras revisadas para o uso do hĂfen em palavras compostas.
El software envĂa instrucciones al hardware para generar las operaciones de la máquina, permitiendo la interacciĂłn entre el software y el hardware que hace posible el funcionamiento del equipo.
El documento resume un estudio sobre las relaciones entre la percepciĂłn del clima motivacional de los padres y la motivaciĂłn autodeterminada en jĂłvenes deportistas. El estudio examinĂł 97 jugadores de fĂştbol entre 12 y 16 años para analizar cĂłmo el clima motivacional percibido de sus padres se relacionaba con sus niveles de motivaciĂłn autodeterminada. Los resultados mostraron que los padres tenĂan una gran implicaciĂłn e influencia en los comportamientos de los jugadores.
This document provides a student research proposal for a project studying adult hippocampal neurogenesis across primate species, including humans. The student aims to quantify and compare the presence of new neurons in the dentate gyrus of various primates to test the hypothesis that humans have greater neurogenesis which could allow for unique episodic memory abilities. The student has experience in neuroanatomy research and aims to continue the project to gain skills relevant to future career goals investigating memory and neurolaw.
O documento discute conceitos de biologia evolutiva como a origem e relações entre organismos, mecanismos de isolamento reprodutivo e os conceitos de homologia, convergência evolutiva e adaptação.
UNIP 4 Semestre -Np2 Fenomenos de Transportesdiasf2003
Â
O documento apresenta três problemas de fenômenos de transporte envolvendo bombas, tubulações e instalações hidráulicas. O primeiro problema descreve uma instalação com bomba de 4cv e 65% de rendimento e pede para calcular velocidades, pressões e altura da caixa d'água. O segundo problema pede para determinar a potência e tipo de máquina em uma instalação com vazão de 62,8 L/s. O terceiro problema pede para determinar a direção e velocidade de um pistão em um circuito hidráulico.
Students in Public Health programs are expected to use the best available research evidence in coursework, practicum placements and upon entry into the public health workforce. This webinar will feature an overview of the process for evidence-informed public health and a model for evidence-informed decision making. Learn more about valuable online resources from the National Collaborating Centre for Methods and Tools (NCCMT) that can help you become skilled in finding and using the best available research evidence and developing the core competencies for public health.
A panel of current MPH students and MPH alumni from various programs across the country will share their experiences of using research evidence in coursework and their public health careers.
The National Collaborating Centre for Methods and Tools is funded by the Public Health Agency of Canada and affiliated with McMaster University. The views expressed herein do not necessarily represent the views of the Public Health Agency of Canada.
NCCMT is one of six National Collaborating Centres (NCCs) for Public Health. The Centres promote and improve the use of scientific research and other knowledge to strengthen public health practices and policies in Canada.
K99/R00 Awards - Pathways to IndependenceUCLA CTSI
Â
Dr. Evans provides considerations in applying for a K99 Award. Provided by the UCLA Clinical and Translational Science Institute. More information at https://ctsi.ucla.edu/education/pages/edtools and https://ctsi.ucla.edu/education/pages/kprogram
Presenter:
Christopher Evans, PhD
Professor of Psychiatry and Biobehavioral Sciences at UCLA
Director, Brain Research Institute
Dr David Galvin - IPPOSI Patient Reported Outcome Measured conference Oct 2018ipposi
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The document summarizes the IPCOR study, which is collecting clinical and patient-reported data on prostate cancer patients in Ireland. The study is led by a team of investigators and aims to improve prostate cancer care in Ireland by establishing national standards, comparing outcomes to other countries, and conducting research. Data is collected longitudinally from patients and held securely to analyze outcomes, quality of life, and make recommendations to improve care while maintaining patient anonymity.
Researchers at Peninsula Health are conducting several studies:
1) A study validating the use of 3D printing for surgical planning by creating models from CT scans and getting surgeon feedback.
2) The first study examining the impact of simulation-based falls prevention training for health profession students on actual patient falls.
3) A study comparing different aquatic physiotherapy exercises for improving balance and reducing falls in Parkinson's disease patients.
4) A study examining the accuracy of radiographer comments on x-rays of broken arms and legs to see if they can help in the emergency department.
This document summarizes a presentation by Prof Sally Spencer on her career in health research and lessons learned. Some key points include:
- She has over 20 years of experience in conducting clinical trials and systematic reviews in areas like COPD and quality of life measures.
- Her first major trial involved collecting over 10,000 questionnaires over 3 years, teaching her important research skills.
- Successful research requires determination, acquiring skills, collaboration across disciplines, and managing expectations of partners.
- Effective time management and navigating regulations and processes can be challenging but seeking help is important.
- Having an open mind, developing networks, and remembering to have fun are also valuable in a research career.
This document provides information about an upcoming pediatric cardiology conference to be held September 22-24, 2016 in Las Vegas, Nevada. It includes details about the conference theme, organizers, keynote speakers, sessions, and registration. The welcome message is from Professor Guy Hugues Fontaine, a famous cardiologist, who discusses his background and contributions to the field. The document outlines the conference agenda over the three days, with 15 tracks covering topics in pediatric cardiology, heart surgery, critical care, and more.
Clinical and Medical Case Reports 2018 brochureElsa Reeth
Â
The document provides an agenda for the 7th International Conference on Clinical and Medical Case Reports to be held in Sydney, Australia from November 08-09, 2018. The agenda outlines the keynote forums, tracks, and sessions to be held over the two day conference on topics related to clinical case reports. It also includes information on registration, abstract submission, and the main theme of the conference which is "Breakthroughs of case reports in Clinical & Medical Research".
Operational research- main techniques PERT and CPMvckg1987
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this presentation mainly deals with operational research giving more focus on pERT and CPM techniques. this two methods are very useful and very confusing while reading but the examples in this presentation makes it very easy to understand this methods and for more study the end slide is provided with references.
Australian Research Council (ARC) & National Health and Medical Research Council (NHMRC) overview
Open Data - Whole of Government Approach
ARC and NHMRC Data Management Requirements
Australian Code for the Responsible Conduct of Research
The adoption of ORCID identifiers by funding organizationsORCID, Inc
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The document discusses options for comprehensively tracking NIH-funded researchers. It proposes:
1) Extending the requirement for NIH eRA Commons accounts to all students and postdocs on NIH projects to capture data in annual reports.
2) Automating NIH Research Training Tables to prepopulate with existing data and share with program directors.
3) Enhancing the SciENcv online biosketch tool to auto-populate biosketches, link researchers to grants and publications using ORCID IDs, and eventually replace uploaded PDF biosketches.
4) Requiring ORCID IDs to help identify individual researchers and their contributions across different systems and agencies.
We are pleased to present the long version of the STARSurg DISCOVER study.
Please feel free to contact STARSurg
w: www.starsurg.org
e: collaborate@starsurg.org
t: @STARSurgUK
Univ of Miami CTSI: Citizen science seminar; Oct 2014Richard Bookman
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The University of Miami's Clinical & Translational Science Institute runs a seminar course for MS students.
This talk surveys 8 citizen science projects, reviews NIH's current activities, and identifies issues for attention, particularly with ethical, legal and social implications.
This document proposes establishing the Pan-Asian Resuscitation Outcomes Study (PAROS) to track out-of-hospital cardiac arrest across Asia. It would collect data on incidence, outcomes, and emergency medical systems from multiple countries to allow for comparisons and identify best practices. The study would be modeled after the Cardiac Arrest and Resuscitation Epidemiology study in Singapore and involve over 13,000 cases collected electronically using common definitions and procedures. Participating countries would study populations totaling over 100 million people. The goal is to understand and improve resuscitation systems to reduce deaths from out-of-hospital cardiac arrest across the region.
This document discusses current and future innovation in the pharmaceutical industry from the perspective of Merck Research Laboratories. It outlines Merck's strategy to discover, develop, and bring innovative medicines to market by pursuing promising science, prioritizing key opportunities, and adapting to a changing landscape. Statistics are provided on Merck's 2018 clinical trial operations, and the relationships between product development teams, clinical sub-teams, and clinical trial teams. Considerations for clinical trial planning, site selection, and protocol design are examined. Pembrolizumab clinical development across many tumor types is reviewed, as are challenges developing a treatment for all genotypes of Hepatitis C.
Identification of Early Career Researchers: How Universities and Funding Orga...ORCID, Inc
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Funding agencies, universities, and research institutes all face challenges of reliably identifying their researchers and monitoring outcomes over time. All researchers—and especially early career researchers seeking to establish their careers—need to be reliably connected to their research outputs, without the confusion common, changeable names creates. Graduate students and postdoctoral researchers supported by grants also have specific challenges: if they are not the PI, they are not included in grant information; they may not even know which grant(s) they are supported by; and as a result, the existing challenges of reliably tying publications to grant funding are even more problematic. The use of the unique, persistent ORCID identifier can help support outcomes tracking and evaluation.
In 2012, the U.S. National Institutes of Health Biomedical Research Workforce Working Group made recommendations that the NIH should take to support a sustainable biomedical research workforce in the U.S. In the course of its study, working group members were “frustrated and sometimes stymied” by the lack of quality, comprehensive data about biomedical researchers. In response, NIH has recommended the development of a simple, comprehensive tracking system for trainees, implemented a shared, voluntary researcher profile system called the Science Experts Network Curriculum Vitae (SciENcv), and encouraged the adoption of unique, persistent ORCID identifiers for researchers. Additionally, NIH has begun collecting data about individuals in graduate and undergraduate student project roles who are supported by NIH grants.
Research universities like Texas A&M are also responding by incorporating the ORCID identifier into their systems, enabling the improved identification, data collection, and career outcome tracking of students and postdoctoral researchers--and educating these early career researchers about the benefits they will receive from a unique, persistent research identifier. They are also beginning to link Electronic Theses and Dissertations (ETDs) to early career researchers' ORCID records.
ORCID is an independent, non-profit organization that provides an open registry of unique and persistent identifiers for researchers and scholars. ORCID collaborates with the community to integrate ORCID identifiers into research systems and workflows, improving data management and accuracy across systems. ORCID enables interoperability between research systems worldwide, ensuring that researchers are correctly and automatically linked to their contributions. Since its launch in October 2012, ORCID has seen rapid adoption by more than 670,000 researchers and 130+ member organizations.
From Webinar 4/23/14, https://orcid.org/content/identification-early-career-researchers-how-universities-and-funding-organizations-are-using
Identification of Early Career Researchers: How Universities and Funding Orga...
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I-Corps_at_NIH_Dec8_Final_508
1. I-Corps from the Trenches
Conversations with I-Corps Alum
December 8, 2016
2. (0 SBIR&STTRCOMING UP LATER TODAY
NCI SBIR
lWITTERCHAT
WITH PROGRAM MANAGER
CHRISTIE CANARIA
THURSDAY, DECEMBER 8, 2016
2 • 3 PM EASTERN TIME
@NCISBIR #SBIRCHAT
2
3. Q&A
sbir.cancer.gov/icorps
Submit your questions through the Q&A chat box
Please submit your questions via the chat box. We will
be answering your questions throughout the webinar,
with additional time dedicated at the end of the
session.
Slides will be made available after the webinar event.
5. White House Demo Day
“We’re scaling up the National Science Foundation’s successful
Innovation Corps program at six more federal agencies so we
can help more of our scientists move their ideas out of the lab
and into the marketplace.”
– President Obama (August 4, 2015)
https://www.whitehouse.gov/the-press-office/2015/08/04/remarks-president-white-house-demo-day
5
6. (0 SBIR&STTRI-Corps™ Training Program
Program Description
• Intensive Entrepreneurial Immersion course aimed at
providing teams with skills and strategies to reduce
commercialization risk
• Curriculum emphasizes Reaching out to Customers to test
hypotheses about the need and market for the technology
being developed.
• Each team is expected to conduct over 100 interviews over
8 weeks.
• Format is focused on Experiential Learning.
@NCIsbir #iCorps
6
9. (0 SBIR&STTRI-Corps™ at NIH
SBIR/STTR Phase II grant applications
have two components
1.The Research Strategy
2.The Commercialization Plan
•Phase II applicants often focus on #1
•The strongest Phase II applications focus on both
Important goal of I-Corps™ at NIH is to
inform the Commercialization Plan
9
10. Focus on Learning
Customer development is NOT sales!
• Teams are not pitching their product or technology
• Teams are listening to potential customers and other
stakeholders and learning about:
• What customers want and need
• Pain points in their customers’ daily routines
• Features of a technology that would provide value
10
11. From I-Corps™ at NIH
3 cohorts to date
• 57 teams conducted 6,362 customer discovery interviews
• >90% found the program “very good” or “excellent”
• >90% would recommend I-Corps™ at NIH to other companies
“We clarified the value propositions, who
our target customers would be, revenue
streams, customer relationships…”
11
“After going through I-Corps we understand we
have to focus on a small subset [of customers] and
prioritize segments based on their value
propositions.”
15. 2011-2014 teams:
324 companies
$93.8M raised
3 acquisitions
As of November
2016:
872 I-CorpsTM Teams
4% 4%
27% 1%
21%
41%
2%
Type of $93.8M
Raised, by Percentage:
SBIR/STTR Phase 1
Corporate
SBIR/STTR Phase 2
Debt
VC Investment
Angel Investment
State Investment
NSF MPS-funded chemists developed imaging agents for biomedical applications
October 2011 – NSF I-Corps participants
June 2012 - NSF SBIR Phase I recipient
April 2014 - NSF SBIR Phase II recipient
State of Nebraska investment
Series A VC investment
June 2016 – Series B VC investment
PI - Stephen DiMagno - Professor at
University of Nebraska-Lincoln
EL - Keil Neumann - current postdoc at UCSF
IM - Allan Green - CEO of Ground Fluor
16. I-Corps Case Study
A new drug to restore function
after spinal cord injury (SCI)
Before I-Corps
• November 2012 -
Dr. Travis Stiles'
discovery published
in Journal of Cell
Science
• August 2014 -
Phase I NIH grants
awarded to develop
drugs for SCI and
stroke
Novoron at I-Corps
• December 2014 -
Novoron completes
I-Corps at NIH
I-Corps at NIH
Learnings & Pivot
Low interest in
early-stage SCI drugs
…but customer
segments are
interested in
Multiple Sclerosis
After I-Corps
• December 2015 - Novoron
Awarded NIH Grant to Evaluate
New Treatments for Multiple
Sclerosis (MS)
• MS work led to increased
interest in new indications
• Entered multiple strategic
partnerships with focus on
negotiating 1 deal
• February 2016 - Xconomy
Recognizes Novoron as San Diego
Life Science Startup to Watch in
2016
• June 2016 - Patent issued
16
17. 17 Participating ICs in 2017
• National Cancer Institute (NCI)
• National Center for Complementary and
Integrative Health (NCCIH)
• National Heart, Lung, and Blood Institute (NHLBI)
• National Human Genome Research Institute
(NHGRI)
• National Institute on Aging (NIA)
• National Institute on Alcohol Abuse and
Alcoholism (NIAAA)
• National Institute of Allergy and Infectious
Diseases (NIAID)
• Eunice Kennedy Shriver National Institute of Child
Health and Human Development (NICHD)
• National Institute of Dental and Craniofacial Research (NIDCR)
• National Institute on Drug Abuse (NIDA)
• National Institute of Environmental Health Sciences (NIEHS)
• National Institute of Mental Health (NIMH)
• National Institute of Mental Health (NIMH)
• National Institute of Neurological Disorders and Stroke
(NINDS)
• National Center for Advancing Translational Sciences (NCATS)
• National Center for Injury Prevention and Control (NCIPC/CDC)
• National Institute for Occupational Safety and Health
(NIOSH/CDC)
#ICorpsNIH
18. PA-16-414 I-Corps at NIH Administrative Supplement
$50,000 budget cap
Application Due Date January 9, 2017
Phone Interview (estimated) February 13-17, 2017
Notice of Award (estimated) March 17, 2017
Course Kick-off April 23-26, 2017
Web-Ex Courses
(1-5PM ET)
May 2
May 9
May 16
May 23
May 30
June 6
Course Close-out/
Lessons Learned
June 12-13, 2017
Cohort Size 24 teams
http://grants.nih.gov/grants/guide/pa-files/PA-16-414.html
#ICorpsNIH
23. Albus Imaging: Week 1, Team 41
•
ISFJ
The Defender
Specialty:
Bioinformatics &
Health Information
Ph.D., Vanderbilt
University
Yaorong Ge, PhD
Industry Expert
The Problem
Today's cancer patient
becomes tomorrow's
heart failure patient
Heart fa ilure is the leading cause
of death of cancer survivors
•
INTP
The Logician
Specialty:
Cardiovascular
monitoring
M BA, MIT
Holly Goodwin, MBA
Principle Investigator
The Solution (i.e. our product)
A diagnostic tool that
identifies who is susceptible
to cardiotoxicity
Early detect ion of
cardiotoxicity = earlier
intervention= heart
injury prevention
ESFJ
ALBUS lMAGING
The Consul
Specialty:
Cardiology & cardiac
imaging
MD, Medical College
of VA
Greg Hundley, MD
C-Level Executive
Who is the customer?
• Physicians
Oncologists
Cardiologists
Other Physicians:
Radiologists
• Patients
• Payors (Healt h Insur Cos., Govt
HC Admins, ACOs, Health Systems)
• FDA
• Pharma Companies@
24. What we learned
• SBIR
– Phase I to II requires a “plan”
• Business outcomes
– Founders “want” to go beyond SBIR
• Learning
– Entrepreneurial skills are “required”
@
30. -
BUSINESS
PLAN
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31. Lean Startup
Agile Engineering
+Part 3
Part 1
+
Part 2
Agile Engineering
32. Building the Nation’s I-Corps
“Innovation Fabric”
I-Corpsď›› Nodes
I-Corpsď›› Sites
I-Corpsď›› Teams
I-Corpsď›› Mentors
33. What you will get and produce
• Your team will
– Be trained in lean startup methods
– Develop answers to your business questions
• You will produce
– A learning journey associated with customers and
the business model canvas – in LPC
– A final presentation and a final video
@
34. Evidence-based Entrepreneurship
Framing
Hypotheses
Customer
Discovery 1 week before
Product
Mentorship
Mandatory Office Hours with Partners, a Mentor dedicated to team,
uses LPC for review, Advisors as domain experts
Education /
Community
Team presents weekly in front of cohort, formal curriculum,
Optional: Office space, weekly dinners w/guest speakers
Lessons
Learned
What we thought, what we did, what we found, what’s next.
Continual Revisions to MVP based on Customer Discovery
Application by BMC, Initial Canvas, Updated Weekly Canvases
10-15 customer interviews/week, present results in front of peers
35. Mutual Expectations
• Relentless
– Urgent and intense activity for 7 weeks
• Direct
– Honest and clear communication
• Hypothesis driven
– Hypothesis: Here’s What We Thought
– Experiments: So Here’s What We Did
– Results: So Here’s What We Found
• Customer discovery
– 100 interviews in 7 weeks
@
37. Albus Imaging: Team Members
Goal: Collaborative
and Productive Team
Observe /
Active Bystander /
Adjudicator
Yaorong Ge,PhD
Industry Expert
• ComputerScientist
&Bioinformatics
Greg Hundley,MD
C-Level Executive
• Cardiologist
• Cardiovascular
ImagingExpert
Move
Debating society
Oppose
Holly Goodwin,MBA
Principle Investigator
• Translationalresearch
• Commercialization of
Cardiovascular
monitoring technologies
38. So here’s what we did….
We got out of the
building!
• We interviewed:
â‚‹ 58Cardiologists
â‚‹ 53Oncologists
ACOs, Payers,
â‚‹ 31Others HCPs, RNs
• Weekly average = 20
â‚‹ 12 =Min
â‚‹ 31 =Max
â‚‹ 20 =Median
â‚‹ 15 =Mode
Plus 10 places in Europe
We always asked who else the interviewee thought
we should talk to <<-- this was very fruitful!
39. ALBUS lMAGlNG
So Here’s What We Are Going ToDo
for the next week!
Just kidding!
We have 10 interviews scheduled for Thursday & Friday.
40. Company 47
Brett Noel, Ph.D.
PI
Steve Ouellette, Ph.D.
C-level
Isaac Schumman, MBA
“Industry Expert”
Product: Preclinical assays to characterize new oncology
therapies
Customers: Biopharma, academics, and preclinical CROs
Why: Save money and time on characterizing candidates in
lead optimization
Interview
Count
TOTAL 102 36 5 61
Academia Number
Professor 11
Lab Director 7
Post-Doc 5
Grad Student 4
Administrator 1
Biotech/Pharma
Scientist 24
Exec.
Leadership
Bus. Dev.
17
7
CRO
Scientist 3
Exec.
Leadership
Bus. Dev.
3
1
Distributors
Bus. Dev. 6
Sales 2
Consultants
Drug Discovery 11
41. Team Profile
Steve Ouellette - Chief Technology Officer & Co-founder
• Ph.D. in Cancer Biology and Molecular Signaling (Purdue)
• Experience at preclinical CRO startup for in vitro toxicity
• Entrepreneurial training and developer of KS biz plan
• Coordinate overall effort of I-Corps team
Brett Noel – Senior Scientist
• Ph.D. in Cancer Biology and Molecular Signaling (Purdue)
• Expertise in core technology and development strategy
• I-Corps – Focus on technically oriented interviews
Isaac Schumann – Business Development Manager
• MBA from Krannert School of Management (Purdue)
• Experience at biochem CRO (Food, paper and biofuels)
• I-Corps – Focus on commercialization oriented interviews
42. Business Model Canvas – Day 1
Original company hypothesis:
There is a market need for technologies to measure cell-based,
endogenous tyrosine kinase activity in preclinical drug development and clinical
diagnostic markets.
43. Senseor kinase inhibitor therapies
The Original Business Model
B.usiness Mo,del
Reagent
Design
Reagent
Validation
Reagent
Optimization
• Diagnostic:s Partners
-
1
Cl'inical hials
- FID.A r,egulatory hurdles
R,e,imbursment
• DnJ,g o·isco,verry Partners
- Pre·-clinical services ond
products
- Early Revenue
45. Changes in Strategy and
Philosophy on Business Models
Drop the clinical applications…for now
Drug Discovery
Re-segment
46. Changes in Strategy and
Philosophy on Business Models
Drop the clinical applications…for now
Drug Discovery
Re-segment
Drug Discovery Clinical
Many business models
47. The Big Pivot:
Revenue Model
Bob Lowery
CEO, Bellbrook Labs
Brian Murphy
Director, Axiogenesis
51. There is a Community Effort Involved
in Driving Adoption
Partners Assay Companies
David Drewry Bill Zuercher Jon Elkins
KOLs
• Publish
• Co-develop
• Endorse
• Present
Complementary Products
Pilot Studies with Potential
Customers
52. In Summary We Learned…
Focus Pivot Community
Final company hypothesis: Kinase inhibitor researchers in preclinical drug
discovery need KinaSense assays to measure kinase activity directly in cellular
models for reducing the time it takes to move a candidate drug from preclinical
development into clinical trials.
53. Future Plans
• Continue building the platform as a research tool
• Establish KOL relationships and collaborations
• Customer discovery and the interview method of learning
will become SOP at KinaSense
• Explore larger market opportunities of the technology
Activities
Phase II Submission Phase II submission expected second half of 2017
Phase I Submission At least 2 additional Phase I applications based on I-
Corps learning
Next 3 months Partnerships with KOLs
License IP to strengthen Phase I application
3rd party funding No plans to pursue before Phase II submission
55. Future Plans- 4 month Follow up
• Continue building the platform as a research tool
• Establish KOL relationships and collaborations
• Customer discovery and the interview method of learning will become SOP at
KinaSense
• Explore larger market opportunities of the technology
Activities
Phase II Submission Phase II submission expected second half of 2017
On Track
Phase I Submission At least 2 additional Phase I applications based on I-
Corps learning On Track (One scored well after I-
Corps insights)
Next 3 months Partnerships with KOLs
License IP to strengthen Phase I application
Finalizing Deals
3rd party funding No plans to pursue before Phase II submission
Have had offers for outside funding
56. Future Plans- 4 month Follow up
• Continue building the platform as a research tool
• Establish KOL relationships and collaborations
• Finalizing a contract with major pharmaceutical company
• Will fund company for at least 1 year
• Customer discovery and the interview method of learning will become SOP at
KinaSense
• Explore larger market opportunities of the technology
Activities
Phase II Submission Phase II submission expected second half of 2017
On Track
Phase I Submission At least 2 additional Phase I applications based on I-
Corps learning On Track (One scored well after I-
Corps learnings)
Next 3 months Partnerships with KOLs
License IP to strengthen Phase I application
Finalizing Deals
3rd party funding No plans to pursue before Phase II submission
Have had offers for outside funding
57. Future Plans- 4 month Follow up
• Continue building the platform as a research tool
• Establish KOL relationships and collaborations
• Finalizing a contract with major pharmaceutical company
• Will fund company for at least 1 year
• Customer discovery and the interview method of learning will become SOP at
KinaSense
• Currently in contact with at least 1 other major pharmaceutical company
• Explore larger market opportunities of the technology
Activities
Phase II Submission Phase II submission expected second half of 2017
On Track
Phase I Submission At least 2 additional Phase I applications based on I-
Corps learning On Track (One scored well after I-
Corps learnings)
Next 3 months Partnerships with KOLs
License IP to strengthen Phase I application
Finalizing Deals
3rd party funding No plans to pursue before Phase II submission
Have had offers for outside funding
58. I-Corps Lessons
• I-Corps is time-consuming
• 40 hours/week
• Research will slow down
• Can you afford to participate in I-Corps?
59. I-Corps Lessons
• I-Corps is time-consuming
• 40 hours/week
• Research will slow down
• Can you afford to participate in I-Corps?
• Customer discovery is a skill that needs development
• Academic articles can be very misleading
• Interviews with customers and key opinion leaders are most important data
points
• Networking leads to an understanding of your market ecosystem
60. I-Corps Lessons
• I-Corps is time-consuming
• 40 hours/week
• Research will slow down
• Can you afford to participate in I-Corps?
• Customer discovery is a skill that needs development
• Academic articles can be very misleading
• Interviews with customers and key opinion leaders are most important data
points
• Networking leads to an understanding of your market ecosystem
• Teaching team and industry mentors are valuable resources
• Experienced entrepreneurs and are invested in your success
61. I-Corps Lessons
• I-Corps is time-consuming
• 40 hours/week
• Research will slow down
• Can you afford to participate in I-Corps?
• Customer discovery is a skill that needs development
• Academic articles can be very misleading
• Interviews with customers and key opinion leaders are most important data
points
• Networking leads to an understanding of your market ecosystem
• Teaching team and industry mentors are valuable resources
• Experienced entrepreneurs and are invested in your success
• Almost every team pivoted in some way
• KinaSense focused early on, accelerated company development timeline by
1-2 years
• Reassessed new SBIR opportunities
• High score on a previously low-priority project
• Many companies made MAJOR pivots
62. I-Corps Lessons
• I-Corps is time-consuming
• 40 hours/week
• Research will slow down
• Can you afford to participate in I-Corps?
• Customer discovery is a skill that needs development
• Academic articles can be very misleading
• Interviews with customers and key opinion leaders are most important data
points
• Networking leads to an understanding of your market ecosystem
• Teaching team and industry mentors are valuable resources
• Experienced entrepreneurs and are invested in your success
• Almost every team pivoted in some way
• KinaSense focused early on, accelerated company development timeline by
1-2 years
• Reassessed new SBIR opportunities
• High score on a previously low-priority project
• Many companies made MAJOR pivots
Can you afford NOT to participate in I-Corps?
63. Q&A
sbir.cancer.gov/icorps
Submit your questions through the Q&A chat box
Please submit your questions via the chat box. We will
be answering your questions throughout the webinar,
with additional time dedicated at the end of the
session.
Slides will be made available after the webinar event.
#ICorpsNIH