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How can a topologically associating domain (TAD) mutation effect more that one gene? Explain
why a TAD mutation shouldn't have any effect on the normal shape of a protein? And what
seems to be one of the normal functions of a TAD.?
Solution
Topological associated domain are genome region whose DNA sequence prefrentially contact
each other.
TAD is a fundamental structural unit that regulates elements to their cognate
promoters.Function: TAD are critical for accurate gene expression Any aleration can lead to
disease

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