The document summarizes the work of the Chicago Department of Public Health over the first 16 months of the Healthy Chicago initiative. Key accomplishments include establishing partnerships to expand smoke-free spaces on college campuses and hospitals, implementing joint enforcement of tobacco laws, increasing bike infrastructure, supporting mobile food vendors, and training students and employees in CPR. The department also worked to increase access to care, implement adolescent health policies in schools, reduce cancer and HIV disparities, and address communicable diseases and healthy homes. Moving forward, the department will build on these initial policy successes and engagement with community partners.