2011 FDA Electoral Fairness Audit of the Syria federal electoral system.
FDA auditors gave Russia an overall electoral score of 35%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of Iraq's federal electoral system
FDA auditors gave Iraq an overall electoral score of 35.25%. (50% is the minimum passing grade; 100% is the maximum grade.)
2011 FDA Electoral Fairness Audit of the France's republic electoral system
FDA auditors gave France an overall electoral score of 91.75%. (50% is the minimum passing grade; 100% is the highest grade attainable.)
2011 FDA Global Electoral Fairness Report on the United States Federal Electoral System.
FDA auditors gave the US an overall grade of 30%. (50% minimum passing grade.)
2011 FDA Global Electoral Fairness Audit of Spain's federal electoral system
FDA auditors gave Spain an overall electoral fairness score of 42.25%. (50% is the minimum passing grade; 100% is the maximum grade.)
2011 FDA Electoral Fairness Audit of the Sweden's republic electoral system
FDA auditors gave Sweden an overall electoral score of 34.5%. (50% is the minimum passing grade.)
U.S. Electoral Fairness Report revised as of April 11, 2013
Executive Summary
The American federal electoral system borders a failed state as determined by the overall unsatisfactory audit score of 54.5 percent (out of 100 percent). The FDA auditors measured
1) two failing scores for legislation pertaining to electoral finance (48.25 percent) and media election content (42.5 percent);
2) one unsatisfactory score for legislation pertaining to candidates and parties
(57 percent);
3) one satisfactory score for legislation pertaining to voters (70.25 percent).
The FDA auditors factored in 52 independent variables and used matrices and financial spreadsheets in its calculations and determinations. Based on its measurements, the FDA believes that the American federal election outcomes may not reflect the voice of Americans from electoral districts. The significant legislated unfair competition between American candidates and parties coupled with electoral finance legislation favoring wealthy money interests and media legislation favoring large corporate media and imbalanced election coverage creates a system tilted heavily to special and minority interests, rather than the American people. The FDA believes that reforms are necessary in electoral finance and election coverage in order to help realign the American federal electoral process with Americans as a whole. The FDA recommends, for examples, expenditure limits on congressional candidates and privately funded presidential candidates, caps on independent third-party expenditure, caps on media ownership concentration, and a voluntary media code of conduct during the 60 day campaign period which supports impartial and balanced campaign coverage of all registered candidates and parties.
The FDA recommends that the public get involved with the government legislative process and implementation if they want to protect and advance their democratic voice, and create a society of their choosing.
“If liberty and equality, as is thought by some, are chiefly to be found in democracy, they will be best attained when all persons alike share in government to the utmost.”
- Aristotle
2011 FDA Electoral Fairness Audit of the Syria federal electoral system.
FDA auditors gave Russia an overall electoral score of 35%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of Iraq's federal electoral system
FDA auditors gave Iraq an overall electoral score of 35.25%. (50% is the minimum passing grade; 100% is the maximum grade.)
2011 FDA Electoral Fairness Audit of the France's republic electoral system
FDA auditors gave France an overall electoral score of 91.75%. (50% is the minimum passing grade; 100% is the highest grade attainable.)
2011 FDA Global Electoral Fairness Report on the United States Federal Electoral System.
FDA auditors gave the US an overall grade of 30%. (50% minimum passing grade.)
2011 FDA Global Electoral Fairness Audit of Spain's federal electoral system
FDA auditors gave Spain an overall electoral fairness score of 42.25%. (50% is the minimum passing grade; 100% is the maximum grade.)
2011 FDA Electoral Fairness Audit of the Sweden's republic electoral system
FDA auditors gave Sweden an overall electoral score of 34.5%. (50% is the minimum passing grade.)
U.S. Electoral Fairness Report revised as of April 11, 2013
Executive Summary
The American federal electoral system borders a failed state as determined by the overall unsatisfactory audit score of 54.5 percent (out of 100 percent). The FDA auditors measured
1) two failing scores for legislation pertaining to electoral finance (48.25 percent) and media election content (42.5 percent);
2) one unsatisfactory score for legislation pertaining to candidates and parties
(57 percent);
3) one satisfactory score for legislation pertaining to voters (70.25 percent).
The FDA auditors factored in 52 independent variables and used matrices and financial spreadsheets in its calculations and determinations. Based on its measurements, the FDA believes that the American federal election outcomes may not reflect the voice of Americans from electoral districts. The significant legislated unfair competition between American candidates and parties coupled with electoral finance legislation favoring wealthy money interests and media legislation favoring large corporate media and imbalanced election coverage creates a system tilted heavily to special and minority interests, rather than the American people. The FDA believes that reforms are necessary in electoral finance and election coverage in order to help realign the American federal electoral process with Americans as a whole. The FDA recommends, for examples, expenditure limits on congressional candidates and privately funded presidential candidates, caps on independent third-party expenditure, caps on media ownership concentration, and a voluntary media code of conduct during the 60 day campaign period which supports impartial and balanced campaign coverage of all registered candidates and parties.
The FDA recommends that the public get involved with the government legislative process and implementation if they want to protect and advance their democratic voice, and create a society of their choosing.
“If liberty and equality, as is thought by some, are chiefly to be found in democracy, they will be best attained when all persons alike share in government to the utmost.”
- Aristotle
2011 FDA Electoral Fairness Audit of the Iran's republic electoral system
FDA auditors gave Iran an overall electoral score of 0%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of the Azerbaijan's republic electoral system
FDA auditors gave Azerbaijan an overall electoral score of 25%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of Saudi Arabia's monarchical electoral system
FDA auditors gave Saudi Arabia an overall electoral score of 0%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of Jordan's parliamentary electoral system.
FDA auditors gave Jordan an overall electoral score of 0%. (0% is the lowest score attainable; 50% is the minimum passing grade; 100% is the maximum score attainable.)
2011 FDA Electoral Fairness Audit of the New Zealand's parliamentary electoral system
FDA auditors gave New Zealand an overall electoral score of 54.75%. (50% is the minimum passing grade.)
operationalizing asthma analytic plan using omop cdm brandtMarion Sills
Secondary use of existing electronic health data from
multiple healthcare organizations requires:
• Harmonization of local data structure with a
common data model.
• Harmonization of local source values with a common
vocabulary
Centralized mapping of local source values allows
standardization across organizations
Data conforming to the OMOP CDM V4 can be used to
operationalize observational CER studies.
Implications for Policy, Delivery, or Practice
Though EHRs all use different backend databases,
they can be harmonized to a CDM for research
purposes. We recommend that the EHR industry
move toward having a standard data model so that
the initial harmonization step is less cumbersome.
ResearchMoz - Polymerase chain reaction (pcr) in medical application an analy...QYResearchReports
Researchmoz presents this most up-to-date research on " ResearchMoz - Polymerase chain reaction (pcr) in medical application an analytical report, 2009-2015 ". The report focuses primarily on quantitative market metrics in
order to characterize the growth and evolution.
he global PCR market is projected to reach around US$27.4 billion by 2015, with a Compounded Annual Growth Rate (CAGR) of 13.9% for the analysis period, 2009-2015. North America is estimated as the largest market with a market share of 40% of global market and projects US$10.7 billion by end-2010. Europe and Asia-Pacific together account for more than 50% of the global market share. Interestingly, Latin America is seen as the fastest growing market with a CAGR of 14.8%, to worth around US$1.3 billion in 2015.
The key considerations of crispr genome editingChris Thorne
While CRISPR is simple to use, widely applicable and often highly efficient, there are a number of things to keep in mind to maximise experimental success. Here's what we recommend...
Fit for Purpose Community Health Surveys: An Experiment in Three CommunitiesICF
Most public health programs are implemented and evaluated at the community level, but few public health data systems generate community measures. National health surveys are too small to provide useful community-level data. Conducting parallel community health surveys could substantially augment the benefits of national surveys, and operationalize findings on the local level. National health data (e.g., physical activity, obesity, cancer screening) becomes more meaningful if it can be compared to local data. Local data is more likely to drive local initiatives, but it becomes more compelling when it can be benchmarked against national trends.
Non-probability samples represent a potential alternative to traditional probability samples in “fit for purpose” designs which weigh the key components of overall success—including accuracy, timeliness, and cost. Specifically, non-probability web panels can generate usable sample sizes within the resources of local agencies. However, the sample must yield estimates that can be considered accurate and representative.
This presentation was originally given at 2015 American Association for Public Opinion Research (AAPOR) Annual Conference.
Visit us for more info: www.icfi.com/SurveyResearch
No Boundary Thinking in Bioinformatics Workshop KeynoteCasey Greene
"The bounty of the commons"
In this talk, we explore how public data can become more valuable with reuse. This reuse helps us get to the bottom of cases where we are certain and wrong and helps us ask better questions.
Examining the Genetic Underpinnings of Commonly Comorbid Language Disorders: ...Golden Helix Inc
Written and verbal language are vital to the development of communication skills. Unfortunately, disorders of these traits—specifically reading disability (RD) and language impairment (LI)—are common, leaving affected individuals at risk for adverse academic, socioeconomic, and psychiatric outcomes. RD and LI are complex traits that frequently co-occur, leading to the hypothesis that these disorders share genetic contributors.
In this webcast, John Eicher of the Yale Child Health Research Center will discuss his search for shared genetic contributors by performing two association scans: (1) Characterizing the contribution of the DYX2 risk locus to RD, LI, and IQ; and (2) A genome wide association study (GWAS) on individuals with comorbid RD and LI.
Eicher found four DYX2 genes, including known risk genes DCDC2 and KIAA0319, and new candidates FAM65B and CMAHP, were associated with RD, LI, and/or IQ. There was a non-additive interaction between two risk variants in DCDC2 and KIAA0319 on reading and language traits. The GWAS of comorbid RD and LI, produced associations with markers in ZNF385D and COL4A2. Markers within NDST4 showed associations with LI. Eicher replicated the association of ZNF385D in the Pediatric Imaging Neurocognitive Genetics (PING) study. Using diffusion tensor imaging on PING subjects, ZNF385D markers were predictors of overall fiber tract volumes and global brain volume. The contribution of DYX2 risk genes, DCDC2 and KIAA0319, and present evidence for FAM65B and CMAHP as new candidate genes are confirmed. Additionally, a new candidate gene for comorbid RD and LI, ZNF385D is implicated. Further study of ZNF385D, a hypothesized transcription factor, should identify target genes of ZNF385D and its neural implications.
2011 FDA Electoral Fairness Audit of the Iran's republic electoral system
FDA auditors gave Iran an overall electoral score of 0%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of the Azerbaijan's republic electoral system
FDA auditors gave Azerbaijan an overall electoral score of 25%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of Saudi Arabia's monarchical electoral system
FDA auditors gave Saudi Arabia an overall electoral score of 0%. (50% is the minimum passing grade.)
2011 FDA Electoral Fairness Audit of Jordan's parliamentary electoral system.
FDA auditors gave Jordan an overall electoral score of 0%. (0% is the lowest score attainable; 50% is the minimum passing grade; 100% is the maximum score attainable.)
2011 FDA Electoral Fairness Audit of the New Zealand's parliamentary electoral system
FDA auditors gave New Zealand an overall electoral score of 54.75%. (50% is the minimum passing grade.)
operationalizing asthma analytic plan using omop cdm brandtMarion Sills
Secondary use of existing electronic health data from
multiple healthcare organizations requires:
• Harmonization of local data structure with a
common data model.
• Harmonization of local source values with a common
vocabulary
Centralized mapping of local source values allows
standardization across organizations
Data conforming to the OMOP CDM V4 can be used to
operationalize observational CER studies.
Implications for Policy, Delivery, or Practice
Though EHRs all use different backend databases,
they can be harmonized to a CDM for research
purposes. We recommend that the EHR industry
move toward having a standard data model so that
the initial harmonization step is less cumbersome.
ResearchMoz - Polymerase chain reaction (pcr) in medical application an analy...QYResearchReports
Researchmoz presents this most up-to-date research on " ResearchMoz - Polymerase chain reaction (pcr) in medical application an analytical report, 2009-2015 ". The report focuses primarily on quantitative market metrics in
order to characterize the growth and evolution.
he global PCR market is projected to reach around US$27.4 billion by 2015, with a Compounded Annual Growth Rate (CAGR) of 13.9% for the analysis period, 2009-2015. North America is estimated as the largest market with a market share of 40% of global market and projects US$10.7 billion by end-2010. Europe and Asia-Pacific together account for more than 50% of the global market share. Interestingly, Latin America is seen as the fastest growing market with a CAGR of 14.8%, to worth around US$1.3 billion in 2015.
The key considerations of crispr genome editingChris Thorne
While CRISPR is simple to use, widely applicable and often highly efficient, there are a number of things to keep in mind to maximise experimental success. Here's what we recommend...
Fit for Purpose Community Health Surveys: An Experiment in Three CommunitiesICF
Most public health programs are implemented and evaluated at the community level, but few public health data systems generate community measures. National health surveys are too small to provide useful community-level data. Conducting parallel community health surveys could substantially augment the benefits of national surveys, and operationalize findings on the local level. National health data (e.g., physical activity, obesity, cancer screening) becomes more meaningful if it can be compared to local data. Local data is more likely to drive local initiatives, but it becomes more compelling when it can be benchmarked against national trends.
Non-probability samples represent a potential alternative to traditional probability samples in “fit for purpose” designs which weigh the key components of overall success—including accuracy, timeliness, and cost. Specifically, non-probability web panels can generate usable sample sizes within the resources of local agencies. However, the sample must yield estimates that can be considered accurate and representative.
This presentation was originally given at 2015 American Association for Public Opinion Research (AAPOR) Annual Conference.
Visit us for more info: www.icfi.com/SurveyResearch
No Boundary Thinking in Bioinformatics Workshop KeynoteCasey Greene
"The bounty of the commons"
In this talk, we explore how public data can become more valuable with reuse. This reuse helps us get to the bottom of cases where we are certain and wrong and helps us ask better questions.
Examining the Genetic Underpinnings of Commonly Comorbid Language Disorders: ...Golden Helix Inc
Written and verbal language are vital to the development of communication skills. Unfortunately, disorders of these traits—specifically reading disability (RD) and language impairment (LI)—are common, leaving affected individuals at risk for adverse academic, socioeconomic, and psychiatric outcomes. RD and LI are complex traits that frequently co-occur, leading to the hypothesis that these disorders share genetic contributors.
In this webcast, John Eicher of the Yale Child Health Research Center will discuss his search for shared genetic contributors by performing two association scans: (1) Characterizing the contribution of the DYX2 risk locus to RD, LI, and IQ; and (2) A genome wide association study (GWAS) on individuals with comorbid RD and LI.
Eicher found four DYX2 genes, including known risk genes DCDC2 and KIAA0319, and new candidates FAM65B and CMAHP, were associated with RD, LI, and/or IQ. There was a non-additive interaction between two risk variants in DCDC2 and KIAA0319 on reading and language traits. The GWAS of comorbid RD and LI, produced associations with markers in ZNF385D and COL4A2. Markers within NDST4 showed associations with LI. Eicher replicated the association of ZNF385D in the Pediatric Imaging Neurocognitive Genetics (PING) study. Using diffusion tensor imaging on PING subjects, ZNF385D markers were predictors of overall fiber tract volumes and global brain volume. The contribution of DYX2 risk genes, DCDC2 and KIAA0319, and present evidence for FAM65B and CMAHP as new candidate genes are confirmed. Additionally, a new candidate gene for comorbid RD and LI, ZNF385D is implicated. Further study of ZNF385D, a hypothesized transcription factor, should identify target genes of ZNF385D and its neural implications.
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Composite quantitative analysis of international healthcare accreditation survey data
1. Composite quantitative analysis
of international healthcare
accreditation survey data
Australian Institute of Health Innovation
Max Moldovan, Charles Shaw and Jeffrey Braithwaite
3. Study and data set description
The first international healthcare accreditation survey
was undertaken in 2000, commissioned by the World
Health Organisation [WHO Review 2003, WHO/EIP/OSD/2003.1]
The current data set has been collected over 2009-2011
44 accreditation agencies, located in 38 countries
10 broad categories of attributes (e.g. “Policy and
governance” and “Funding of the organization”)
173 questions leading to categorical, date/numeric or
free text responses
4. Geographical and age distribution of accreditation agencies*
Older than 20 years
Between 10 and 20 y.o.
* If more than one program per country, the oldest program is displayed
<10 y.o.;
5. Methods of analysis
Stratified categorical analysis
Supervised learning via penalised regression
Unsupervised learning via hierarchical clustering
6. Stratified categorical analysis
Organisations are stratified into two or more
groups based on observed factors
Responses arranged into contingency tables
Fisher’s exact conditional testing is applied
The results are assessed based on the plots of
sorted P-values
7. Stratified categorical analysis
Stratification factors:
1.Purchasing Power Parity adjusted GDP per capita
2.Government relatedness
3.Regional factor
4.Age of organisation
5.Country of origin population
9. Supervised learning via
penalised regression
R package penalized: Penalised regressions via L1
and L2 penalties [Goeman (2010): Biometrical Journal 52 (1), 70–84]
L1: LASSO; L2: ridge; L1 and L2: elastic nets
Only L1 penalty (LASSO) has been used
Supervisory (response) variable is an ordinal fourlevel categorical variable defined by field experts
(similar to phenotypes defined by clinical experts)
Explanatory variables are categorical responses
coded as factors
Logistic link function has been used
11. Supervised learning via
penalised regression
Vitality categorisation (“phenotype”):
0 – on “life support” and unlikely to survive
1 – hardly functional and deteriorating
2 – functional, with signs of improvement
3 – alive and well
12. Supervised learning via
penalised regression
The set of shifted (“phenotype”) response variables:
yi,1 – refined “deprived”: 0 vs. 1-2-3
yi,2 – mid split: 0-1 vs. 2-3
yi,3 – refined “winners”: 0-1-2 vs. 3
20. Unsupervised learning via
hierarchical clustering
R function daisy (package cluster) has been used
207 categorical attributes have been coded as
asymmetric binomials
Dissimilarity matrix has been computed based on
Gower’s dissimilarity coefficient [Gower (1971) Biometrics 27,
857–874 ]
Dendrograms are based on Ward’s hierarchical
clustering method
Weights are imposed as an inverse of attribute
counts within each category
24. Example of results triangulation
It has been identified that the legal status of organization
is associated with the GDP PPP per capita factor
(stratified analysis) => This association can be attributed
to economic/social factors beyond the direct control
Relatively wealthy Portugal fell into a “deprived” cluster in
the Policy and Governance motivated dendrogram (cluster
analysis)
POL3a (What is the legal status of the accreditation
organization?: government agency) has been identified as
highly important attribute contributing to failure (LASSO)
It can be recommended to change the legal status
![Healthcare accreditation:
a process that a health care institution, provider, or program
undergoes to demonstrate compliance with standards
developed by an official agency.
[Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health,
Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)