Grails 2.0 and ASP.NET MVC 4 are web application frameworks that implement the model-view-controller pattern. Some key differences include: 1. Grails uses the Groovy programming language which runs on the Java virtual machine, while ASP.NET MVC uses .NET languages like C# that run on Windows. 2. The ASP.NET MVC community is larger due to the popularity of C#, but Grails has lower costs since it can be developed and deployed for free using open source tools. 3. Grails requires less operating system knowledge as it has little relationship with the OS, whereas ASP.NET MVC requires knowledge of Windows updates and patches due to its close