“Global Transdermal Patch Market and Clinical Pipeline Outlook 2022” report highlights:
Introduction and Classification of Transdermal Patch
Mechanism of Transdermal Patch Drug Delivery
Transdermal Patch v/s Traditional Drug Delivery Methods
Global Transdermal Patch Clinical Pipeline Overview
Marketed Transdermal Patch Clinical Insight by Company, Indication and Phase
Global Transdermal Patch Market Future Prospects
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A comprehensive research report created through extensive primary research (inputs from industry experts, companies, stakeholders) and secondary research, the report aims to present the analysis of Global Psoriasis Pipeline Drugs Market by assessing the potential of the six drugs that will be launched in the near future. Also, the report assesses the results of various clinical trials undertaken for each of the six drugs, the product profile, description and regulatory phase of each of the six drugs. Also, 7Ps Analysis (Patent, Phase, Pathway, Patient, Physician, Payer, Partner) has been done for each of the six drugs to present the current perspective.
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“Global Non-Invasive Prenatal Testing Market: Demand, Insights, Analysis, Opportunities, Growth Potential and Forecast 2018 – 2025” presents an in-depth assessment of the Global Non-Invasive Prenatal Testing (NIPT) market dynamics, opportunities, future roadmap, competitive landscape and discusses major trends. The report offers the most up-to-date industry data on the actual market situation and future outlook for Global Non-Invasive Prenatal Testing (NIPT). The research includes historic data from 2014 to 2017 and forecasts until 2025.
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In recent years, the pharmaceutical industry has witnessed increased political interest and attention due to the increased recognition of the economic importance and financial impact of healthcare as a component of national budgets. Biologic drugs (biologics) have attracted the attention of politicians since biologics have moved out of the niche pharmaceutical arena to contribute 17% of global pharmaceutical sales, representing revenues of more than $120bn in 2009. The market for biologics is growing at twice the rate of pharmaceutical drugs, placing significant cost pressures on government, employers, insurers, and patients. Government and insurers are using several strategies to contain costs but must ensure that the financial burden placed on patients does not restrict access to the health care system. Establishing a regulatory pathway for ‘follow-on’ biologics (biosimilars) was therefore felt to be necessary by many stake holders to encourage competition and reduce prices. Many pharmacutical companies both large and small - are expecting their bottom line growth to be driven by biosimilars and are channeling their R&D budgets to compete in what – according to many - is going to be one of the hottest areas in a radically changing global pharmaceutical market.
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60 seconds with steve hobbs pharma times aprilSteve Hobbs
Patients and Healthcare Professionals can scan a unique code on the pharmaceutical packaging/label with their smartphone to instantly access information and download Apps to help improve health outcomes.
Unicheck has a Secure Global Platform for Individual Product Tracking & Tracing, Authentication and Anti-Counterfeiting and 1:1 Customer Communication
www.unichecksrl.com
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More Info:- https://www.imarcgroup.com/intermittent-catheters-market
COVID-19 Impacts on the Global mRNA Vaccines and Therapeutics Market NarayanSharma67
The “Global mRNA Vaccines and Therapeutics Market” is likely to grow at a CAGR of around 13% during the forecast period, i.e., 2021-26, says MarkNtel Advisors. The market growth essentially attributes to the rising prevalence of infectious and chronic diseases, including HIV, diabetes, cancer, and cardiovascular diseases.
Scaffold Technology Market Size & Forecast, By Product (Hydrogels, Micro-Patterned Surface Microplates, Polymeric & Nanofiber Scaffold), By Application, By End-Use And Trend Analysis From 2018 To 2024
Biomarkers are novel diagnostic tools that provide intelligence to physician about disease progression and treatment effects. Advancement in understanding of human genome promotes its application in diagnosis of disease on molecular basis. Biomarker technology is evidencing increased application in disease diagnosis, drug development and formulation, diagnosis for exposure of certain harmful chemical and prognostic treatments.
There will be a steady increase in demand for new diagnostic testing services in the next five-year period, along with pressures to improve the quality of healthcare delivered in the clinic and also to lower its costs. Clinical labs experienced a substantial growth during the last decade.
60 seconds with steve hobbs pharma times aprilSteve Hobbs
Patients and Healthcare Professionals can scan a unique code on the pharmaceutical packaging/label with their smartphone to instantly access information and download Apps to help improve health outcomes.
Unicheck has a Secure Global Platform for Individual Product Tracking & Tracing, Authentication and Anti-Counterfeiting and 1:1 Customer Communication
www.unichecksrl.com
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The global intermittent catheters market size reached US$ 2.7 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 4.7 Billion by 2032, exhibiting a growth rate (CAGR) of 6.02% during 2024-2032.
More Info:- https://www.imarcgroup.com/intermittent-catheters-market
Adhesion Barriers Market by Product Type, Distribution Channel, End User 2024...IMARC Group
The global adhesion barriers market size reached US$ 1,048.2 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 1,822.1 Million by 2032, exhibiting a growth rate (CAGR) of 6.1% during 2024-2032.
More Info:- https://www.imarcgroup.com/adhesion-barriers-market
Global antibody drug conjugate market & pipeline insight2020KuicK Research
" Global Antibody Drug Conjugate Market & Pipeline Insight 2020" Report Highlight:
Global Antibody Drug Conjugates Market Overview
Mechanism of Antibody Drug Conjugates
Global Antibody Drug Conjugates Clinical Pipeline by Company, Indication & Phase
Global Antibody Drug Conjugates Clinical Pipeline: 148 ADC
Marketed Antibody Drug Conjugates Clinical Insight: 8 ADC
Antibody Drug Conjugates Patent Analysis
Global Antibody Drug Conjugates Market Future Prospects
Download Global antibody drug conjugate market & pipeline insight2020KuicK Research
\" Global Antibody Drug Conjugate Market & Pipeline Insight 2020\" Report Highlight:
Global Antibody Drug Conjugates Market Overview
Mechanism of Antibody Drug Conjugates
Global Antibody Drug Conjugates Clinical Pipeline by Company, Indication & Phase
Global Antibody Drug Conjugates Clinical Pipeline: 148 ADC
Marketed Antibody Drug Conjugates Clinical Insight: 8 ADC
Antibody Drug Conjugates Patent Analysis
Global Antibody Drug Conjugates Market Future Prospects
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The global medical membrane market size reached US$ 3.9 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 7.7 Billion by 2032, exhibiting a growth rate (CAGR) of 7.5% during 2024-2032.
More Info:- https://www.imarcgroup.com/medical-membrane-market
Endoscope Reprocessing Market PPT: Overview, Dynamics, Trends, Segmentation, ...IMARC Group
The global endoscope reprocessing market size reached US$ 2.2 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 4.0 Billion by 2032, exhibiting a growth rate (CAGR) of 6.8% during 2024-2032.
More Info:- https://www.imarcgroup.com/endoscope-reprocessing-market
Vaccine Adjuvants Market by Product Type, Distribution Channel, End User 2024...IMARC Group
The global vaccine adjuvants market size reached US$ 996.5 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 2,639.3 Million by 2032, exhibiting a growth rate (CAGR) of 11.1% during 2024-2032.
More Info:- https://www.imarcgroup.com/vaccine-adjuvants-market
Hysteroscopes Market Growth, Demand and Challenges of the Key Industry Player...IMARC Group
The global hysteroscopes market size reached US$ 292.5 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 441.4 Million by 2032, exhibiting a CAGR of 4.54% during 2024-2032.
More Info:- https://www.imarcgroup.com/hysteroscopes-market
Infantile Spasms Therapeutics Market by Product Type, Distribution Channel, E...IMARC Group
The global infantile spasms therapeutics market size reached US$ 3.5 Billion in 2022. Looking forward, IMARC Group expects the market to reach US$ 4.5 Billion by 2028, exhibiting a growth rate (CAGR) of 4.2% during 2023-2028.
More Info:- https://www.imarcgroup.com/infantile-spasms-therapeutics-market
Organ Preservation Market Growth, Demand and Challenges of the Key Industry P...IMARC Group
The global organ preservation market size reached US$ 187.9 Million in 2023. Looking forward, IMARC Group expects the market to reach US$ 313.4 Million by 2032, exhibiting a growth rate (CAGR) of 5.7% during 2024-2032.
More Info:- https://www.imarcgroup.com/organ-preservation-market
The global vaccine delivery devices market size reached US$ 7.0 Billion in 2022. Looking forward, IMARC Group expects the market to reach US$ 10.9 Billion by 2028, exhibiting a growth rate (CAGR) of 7.5% during 2023-2028.
More info:- https://www.imarcgroup.com/vaccine-delivery-devices-market
Telemedicine Market Growth, Demand and Challenges of the Key Industry Players...IMARC Group
The global telemedicine market size reached US$ 74.7 Billion in 2023. Looking forward, IMARC Group expects the market to reach US$ 465.3 Billion by 2032, exhibiting a growth rate (CAGR) of 22.9% during 2024-2032.
More Info:- https://www.imarcgroup.com/telemedicine-market
Global Single Use Disposable Endoscopy MarketRenub Research
Single Use-Disposable Endoscopes Market is expected to hit around US$ 6.71 Billion by 2030, according to Renub Research. Endoscopy has revolutionized the clinical panorama through presenting non-surgical techniques for correct prognosis, intervention, and tracking of a big range of medical situations.
Telemedicine Market by Product Type, Distribution Channel, End User 2023-2028IMARC Group
The global telemedicine market size reached US$ 59.7 Billion in 2022. Looking forward, IMARC Group expects the market to reach US$ 218.0 Billion by 2028, exhibiting a growth rate (CAGR) of 21.9% during 2023-2028.
More Info:- https://www.imarcgroup.com/telemedicine-market
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US Orphan Drug Pipeline by Phase, Indication & Originator
Marketed Orphan drug List by Indication & Brand Name
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
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and severe subclassifications (American Psychiatric Association, 2013).
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combined into a single substance use disorder (SUD) on a continuum
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drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
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comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Evaluation of antidepressant activity of clitoris ternatea in animals
Global transdermal patch market and clinical pipeline outlook 2022
1. Global Transdermal Patch Market and Clinical Pipeline Outlook 2022
For Sample contact: neeraj@kuickresearch.com ; +91-11-47067990 Page 1
“Global Transdermal Patch Market and Clinical Pipeline Outlook 2022” report discusses the
ongoing clinical and non-clinical parameters with respect to development of global
transdermal patch market. Report highlights the need for integration of transdermal patches
in existing drug delivery methodology available to pharmaceutical companies. Currently there
40 transdermal patches available in the market and more than 70 patches are in clinical
pipeline.
Transdermal patches have made their place in global market in past few decades as an
alternative to conventional therapeutic for various disease indications. Systemic drug delivery
could be achieved by oral and prenatal methods but they have several limitations due to
which many patients often find them inconvenient. Pharmaceutical companies have identified
these problems as an opportunity to develop transdermal patches for generating significant
revenues. This problem was identified early and advancements in biotechnology helped in the
introduction of transdermal patches in global market. Nowadays, they are available for
different disease indications and generally found suitable for large number of people having
different disease indications. As a result, numbers of users are escalating at tremendous rates
which are steadily increasing the global size.
Transdermal patches are widely accepted among physicians and patients due to their non-
invasive, pain free and easy administration. In recent years, the growth of transdermal patch
market has increased and expected to increase significantly in coming years. Higher
investments in research and development could be attributed to the success of transdermal
patch market. Number of disease indication treated by them is increasing steadily leading to
higher market penetration. Every year various transdermal patches are introduced in globally
leading to increased market size.
Transdermal patches presently donning the market are formulated in accordance with
requirement of the medicinal therapy. They can be worn for as low as 8 hours to as long as 7
days depending on the therapeutic indication. These patches are secured with adhesives,
which are designed to adhere comfortably to the skin which in turn allows a patient to use
the patches for as long as is indicated by his or her physician. Transdermal drug delivery
provides excellent control of the rate of delivery directly into the bloodstream. It also offers
a predictable pharmacokinetic profile and constant drug levels over extended periods of time
without the extreme peak/trough fluctuations inherent in oral administration with the
inherent power of discontinuation of therapy immediately by simply removing the patch.
2. Global Transdermal Patch Market and Clinical Pipeline Outlook 2022
For Sample contact: neeraj@kuickresearch.com ; +91-11-47067990 Page 2
Strong clinical pipeline could be observed in case of transdermal patches which reflect the
interest of pharmaceutical companies in this segment. Before marketing approval they have
to undergo strict testing and checking for various qualitative parameters. They must be
stable, chemically unreactive, hypo allergic, nontoxic and easy to manufacture. High
throughput methods are expected to increase the suitable polymer screening rates along with
reduced time consumption. Bioequivalence of therapeutic in transdermal patch with same
drug administrated via different route have known efficacy must be shown. Similarly,
independent of patch type they must show bioequivalence in clinical trials before getting
marketing approval from medical regulatory authorities. Various products are at different
stages of clinical trials which will be introduced in global market in coming years.
“Global Transdermal Patch Market and Clinical Pipeline Outlook 2022”
report highlights:
Introduction and Classification of Transdermal Patch
Mechanism of Transdermal Patch Drug Delivery
Transdermal Patch v/s Traditional Drug Delivery Methods
Global Transdermal Patch Clinical Pipeline Overview
Marketed Transdermal Patch Clinical Insight by Company, Indication and Phase
Global Transdermal Patch Market Future Prospects
For Report Sample Contact: neeraj@kuickresearch.com
3. Global Transdermal Patch Market and Clinical Pipeline Outlook 2022
For Sample contact: neeraj@kuickresearch.com ; +91-11-47067990 Page 3
Table of Contents
1. Introduction to Transdermal Patch
2. Classification of Transdermal Patches
2.1 Single/ Multiple-Layer Drug-in-Adhesive
2.2 Reservoir Transdermal Patches
2.3 Matrix Based Transdermal Patches
2.4 Vapor Patch
2.5 Active & Passive Patch
3. Why There Exist Need for Transdermal Patches?
4. Mechanism of Transdermal Patch Drug Delivery
4.1 Properties of Transdermal Therapeutics
4.2 Components of Transdermal Patch
4.3 Mechanism of Motion Sickness, Nicotine & Female Contraceptive Transdermal Patch
5. Transdermal Patch v/s Traditional Drug Delivery Methods
6. Global Transdermal Patch Market Outlook
6.1 Global Market Scenario
6.2 Regional Trends
7. Global Transdermal Patch Clinical Pipeline Overview
7.1 By Phase
7.2 By Region/Country
7.3 By Drug Class/Molecule
7.4 By Company
7.5 By Orphan & Fast Track Status
7.6 By Mode of Action
8. Global Transdermal Patch Market Dynamics
8.1 Favorable Market Parameters
8.2 Commercialization Challenges
9. Global Transdermal Patch Market Future Prospects
10. Global Transdermal Patch Clinical Insight
10.1 Unknown
10.2 Research
10.3 Preclinical
10.4 Clinical
10.5 Phase-I
10.6 Phase-I/II
10.7 Phase-II
10.8 Phase-II/III
10.9 Phase-III