This document discusses Ambiance Ventures' capabilities in international distribution of vaccines, biologics, specialty pharma, generics, hospital supplies and diagnostics. It outlines their services such as regulatory support, logistics, order processing, accounts receivables, government and private sales, repackaging, delivery and more. It also provides details on their operations in India, affiliates in other countries, and ability to source products from manufacturers to consolidate and distribute globally.

1. INTERNATIONAL MARKET DEVELOPMENT VACCINES ,BIOLOGICS, SPECIALTY PHARMA, GENERICS, HOSPITAL SUPPLIES & DIAGNOSTICS AmbianceVentures

2. OUR CAPABILITIES IN GLOBAL MARKETS GOVERNMENT (Public) MARKETS PRIVATE MARKETS AmbianceVentures

4. Pharmacovigilance – Follow-up and tracking

5. Bridging studies – Follow-upAmbianceVentures

7. Accredited bidders – Principal-to-Agent Agreement

8. Comply with paperwork for government tenders

9. Physical presence required during bid opening process

10. Negotiate bidding prices – 1 cent difference in price can win or lose tender!

11. Consolidation of local orders for differed deliveries, drop shipments.

12. Multiple agents for govt. bids, private markets , institutional markets

15. Obtain required certification, licenses

16. Follow-up on application through multiple agencies

17. Submit samples, submit analytical, BE studies and clinical reports

19. Registration with ‘local government’ (state / province)

20. Registration for private distribution in ‘cooperatives’AmbianceVentures

22. Periodic follow-up (weekly)

23. Most Governments DO NOT OPEN Letters of Credit

24. Customs documentation is CRITICAL

25. Comply with specified product delivery criteria

26. INCOMPLETE OR INACCURATE DOCUMENTATION CAN RESULT IN INORDINATE DELAYS IN PRODUCT LAUNCH, OR OUTRIGHT REJECTION

27. Delays in product delivery and improper storage at govt. appointed facilities can result in damage, loss of potency , product obsolescence – write off, returned product and additional cost for disposal or reverse logistics AmbianceVentures

29. Reputation in private market supply chain

30. Supply logistics, cold chain, customer service

31. Institutional : Large insurance companies, Hospital chains

32. Retail: Pharmacy chains

33. Wholesalers: Physician offices

34. National level programs through private clinics

35. Create Local Advisory Boards; Strong connections with KOLsAmbianceVentures

37. Terms vary from 90 – 180 days credit

38. Sometimes bank guarantees can be obtained.

41. Receiving shipments, ensuring cold-chain at port / airport

42. Deal with port authority, associated bureaucrats and labor unions

43. Reduce risk of product damage and obsolescence

44. Freight consolidation – in-bound and out-bound

45. Re-packaging, re-dressing or special labeling in controlled environment

46. Storage permits and licenses

47. Cold chain validation

48. Proof of delivery procedures

49. Documentation:

50. Packaging list, Invoice, CoA, Customs Duty,

51. Point to point delivery: inland distribution to multiple final destinations

52. Return of expired, damaged or defective product

53. Disposal of expired, damaged or defective productAmbianceVentures

55. Contacting reporting medical facility for liaison

56. Product recalls when necessary

57. Submit samples of ‘defective’ product to authorized labs.

58. Destruction of returned product if necessaryAmbianceVentures

60. Design a step approach for future marketing needs in international markets.AmbianceVentures

61. Who is……? Our Operations in India Principal Role: International Logistics & Distribution Exports & Imports Freight Consolidation Customs Documentation & Clearance Product Registration Regulatory Filings Bridging Studies, Bioequivalence Studies Storage, Warehousing, Cold Chain Distribution. Dependable source for Biologics, Pharmaceuticals, Diagnostic Products and Hospital Supplies AmbianceVentures USA

63. Export APIs, Finished Products, POC / In-vitro Diagnostics

64. Contract Manufacture

65. Neutral Label & Private Label Manufacture

66. Global Marketing Assistance

67. Complete Export Documentation – Registration, Customs, RegulatoryAmbianceVentures USA

68. GLOBAL MARKETING, TRADE & BUSINESS STRATEGY We market in the following countries: North America: United States, Canada, Mexico European Union: United Kingdom, Germany, Italy, Russia, Bulgaria, Hungary, Portugal, Spain, Ireland Latin America / Central America: Argentina, Brazil, Chile, Bolivia, Peru, Panama, Caribbean Is., Guyana, Surinam, Colombia Asia, West Asia & Pacific: Afghanistan, Bangladesh, Bhutan, Cambodia, China, Indonesia, Iran, Iraq, Jordan, Middle East Nations, Malaysia, Philippines, Sri Lanka, Taiwan, Turkey, Vietnam Africa: Cameroons, Congo, Egypt, Ghana, Kenya, Libya, Mauritius, Morocco, Sudan, South Africa, Uganda, Zambia CIS Countries: Ukraine, Russia, Kazakhstan, Uzbekistan, Armenia, Tajikistan AmbianceVentures USA

70. including Private Label, Neutral Label, Govt. Label

71. Biologics – Adult & Pediatric Vaccines, Sera and Anti-venoms

72. Our current focus: H1N1 (Swine Flu) Vaccine, Seasonal Flu Vaccine.

73. Hospital Supplies – Private Label and Generic

74. Pharmaceutical Ingredients: APIs, Empty Capsules, Excipients,

75. Fine Chemicals, Intermediates

76. Lab Supplies: Instrumentation, Reagents and Chemicals

77. Dental Products and supplies

78. Packaging Materials: Vials, Ampoules, Bottles, Blister packs, Aluminum Foils

79. Diagnostic Tests and Devices: HIV, Pregnancy, Diabetes, Malaria, STDs,

80. OTC and Personal Care Products – Branded, Generic and Private Label –

81. Custom manufactured at our own facilities in Dubai Tax Free Zone or IndiaAmbianceVentures USA

82. Outsource your Export Marketing, Regulatory and Customs formalities to us: We have an established and reliable Worldwide infrastructure for Marketing and logistically sound Distribution, capable of handling large or small volumes. Deep contacts and superior reputation within Governments and Private Markets resulting from 28 years of international business dealings Dependable Agents / Distributors across all continents who will pro-actively promote your products to focused target segments, Ministries of Health and non-governmental entities at Federal, Provincial and Local levels The Best of Logistics in terms of Warehousing, Cold Chain for timely deliveries. Expertise in Shipping, Scheduling, Consolidation for FCL shipments, Optimal use of container space, Economical and timely Routing, Freight Insurance. World-class Air and Sea Connections Efficient Customs handling including pre-shipment inspections of product, packaging, labeling, shipping marks AmbianceVentures USA

83. Former President of India – Dr. A.P.J. Kalam, and the Hon. President of the Philippines – Gloria Macapagal Arroyo preside over signing of agreement with Valerian Lobo (Feb 2006) LOB International was appointed ‘Authorized Sourcing Agent’ by The Philippines Ministry of Health for supply of Pharmaceuticals, Biologics and Hospital supplies from India AmbianceVentures USA

85. NEWEST PRODUCTS & FORMULATIONS – Far Superior to existing players!

86. Marketing of Vaccines to Government & Private markets

87. Rapid formulation, development and commercialization per US FDA standards

88. Client will own the Intellectual Property for formulation, development and manufacture.

89. Leverage local know-how in India to deal with bureaucracy and the government

90. Enjoy benefits of local manufacture and exports to other countries

91. Import finished products in Generics, Diagnostics and APIsAmbianceVentures USA

92. OTHER SERVICES in Life sciences from Our US Office: Strategic Consulting & Market Development Services Client Profile: Biotechnology, Pharmaceutical, Medical Device and Healthcare Companies in US, Canada, Latin America, India & China. Areas of Expertise: Contract Manufacture Bulk Drugs, API Imports Generic Drug Formulation, Development & Validation Alliance Management: Identify partners, Due Diligence, Venture Capital Country Representation: US, India, Latin America, Europe Medical Conventions, Trade Shows, Speakership, Advisory Boards Strategic Marketing, New Product Commercialization Outsource Clinical Trial Design, Site Management, BA/BE Studies Thought Leader Development, Business Intelligence Expertise in multiple therapeutic areas AmbianceVentures USA

94. Generic substitution, LOW COST, HIGH QUALITY, TIMELY PRODUCTION

95. Need to access specialized, economical mfg technology and methods

96. Have alternate mfg. sources in the event of supply interruptions

97. Unforeseen increase in demand

98. One-stop-shop for all PHARMA products and diagnostics needs

99. Our 28-year experience in sourcing for generics, contract mfr, combined with buying power in India, China, Thailand, and other promising supply sources globally. AmbianceVentures USA

101. ISO 13485

102. cGMP

103. ANVISA (Brazil)

104. FDA (United States)

105. EMEA (European Union)

106. SAHRPA (South Africa)

107. ANMAT (Argentina)AmbianceVentures USA

109. Anti-TB cocktails

110. Anti-Malaria cocktails

111. Biogenerics for Cancer

112. Cardiovascular

113. Antibacterials

114. Immunosuppressants

115. Hormonal, Infertility

116. Erectile Dysfunction

117. Sclerosants

118. Mucolytic agents

119. Anti-pyretics

120. Cough and Cold

121. Pediatric & Adult Vaccines

122. H1N1 (Swine Flu) Vaccine-2010-11 SeasonAmbianceVentures USA

124. Specialists in Government Contracts, Private Market

125. Drop shipments

126. All Customs and Shipping Documentation

128. Indication

129. Chemical name or composition

130. Form of Product (tablet, capsule, liquid, gel, powder) / Bulk

131. Strength (100mg, 250ml, etc.)

132. Quantity per shipment (kgs., litres, units)

133. Packaging (drums, bottles, strips) – MULTIDOSE, PRE-FILLS

134. Shipment Packaging requirements

135. Labeling Requirements – Regulatory ComplianceAmbianceVentures USA

137. INFLUENZA

138. Pregnancy

139. HIV ( 1 & 2)

140. Hepatitis

141. Malaria

142. Dengue

143. Chikungunya

144. Syphillis

145. TB

146. Cardiac Markers

147. Dry Chemistry

148. Bio-chemistry

149. Hematology

150. Immunology, Rheumatology

151. ELISAs for Body FluidsIdeal for Rural Clinics, Pharmacies; can be manufactured ‘Private Label’ AmbianceVentures USA

152. OUR SPECIALTY: Leverage low cost contract manufacture at our facilities! NEUTRAL LABEL, PRIVATE LABEL CONTRACT MANUFACTURE: Vaccines, Generics, Cosmetics, Diagnostics, FMCG Custom Packaging – For Re-distribution Neutral (‘generic drug’) labelingper Ministry of Health requirements of numerous Countries in multiple languages In Portuguese / English / Spanish / French / Cyrillic / German / Arabic Private labeling with your own Brand Name, Company Identity, Compliant with regulations – Pharmacies, HMOs, Export, or for Secondary Distribution AmbianceVentures USA

154. 5000 sq. feet of Warehouse space

156. All Philippine Govt. tenders are routed through us.Affiliate Offices in China: Sourcing offices in Guangzhou, Yiwu, Shenzhen, Hong Kong, Shanghai OTC, Dental Hygiene Contract Manufacturing Plant in Dubai AmbianceVentures USA

158. One-stop-shop for multiple products resourced from numerous mfrs.

159. We specialize in small orders and shipments - consolidated into container loads

160. Not all mfrs supply all your requirements. We source for you and consolidate smaller shipments for FCL rates

161. Helps your customers to minimize paperwork and transactions with multiple buyers – e.g. multiple letters of credit, multiple bills of lading

162. We take on the ‘headaches’ of logistics and excise /customs at port of origin even for smaller shipments to combine loads into affordable freight rates AmbianceVentures USA

164. We pass the benefits on to you!

165. We represent manufacturers from India, China, Thailand, Europe, United States

166. All clients we represent are WHO, cGMP compliant, and many are ANVISA, US-FDA or EMEA approved

167. We work with you for Due Diligence including your visits to mfg. facilities in Asia for monitoring regulatory compliance, inspections

168. You can leverage low cost contract manufacturing at our facilitiesAmbianceVentures USA

169. Affiliate of Ambiance Ventures USA We are yourOffice Address in India As our Partner / Client, you may use our Offices and Warehouse facilities in Mumbai (Bombay) as your own: On your Website On Letterheads In Correspondence and Applications During visits to India by you or your clients Separate Phone and Fax lines for your company Assign a designated rep to respond on your behalf AmbianceVentures USA

170. BRAZIL - Update Govt. Market H1N1: Brazil’s MinisteriodaSaude is buying a total of 83 million doses of vaccine against influenza A virus (H1N1), which will be used in a vaccination campaign planned for the period March to April 2010 – FIRST ROUND Supply contracts: GSK, Sanofi Pasteur - 33 Million doses from Sanofi at $7.60 /dose via InstitutoButantan for first responders and susceptible population PAHO to provide 10 Million doses later(??) Potential for at least 5-6 Million more doses if price is right! (Priority groups such as pregnant women, health workers involved in patient care, children from 6 months to 2 years, indigenous people and people with chronic pre-existing conditions (cardiac, pulmonary, renal, metabolic, etc.) Details of strategy will be announced early February). Private Market H1N1: 12-15 Million doses Seasonal:Public: 17 Million doses; Private: 3 Million doses AmbianceVentures USA

173. Birth rate: 16.56 births/1,000 population (2006 est.)

174. Death rate: 6.17 deaths/1,000 population (2006 est.) AmbianceVentures USA

175. Sales Force Structure: Our Operations in Brazil Field Force Distribution Field Force Medical Reps: 50 Sales Coordinators: 02 Sales National Manager: 01 Product Manager: 01 Total: 54 AmbianceVentures USA

176. Brazilian Vaccines Market Estimating a CARG 6.5%/Year: The Market in 2008  $ 330 million (US$ =2.00) AmbianceVentures USA

177. Latin America Business Development Model 1- Regional (multinational) Innovative Partnership [ Win-Win Project – WWP] 1- A new core product is located by one of the partners (PA, PB, PC. PD…) 2- The International Project Team is activated (country representatives) 3- Marketing, Sales and Regulatory evaluation is performed in each country by the team. 4- The Regional Dossier with Regulatory, MKT & Sales potential is provided to the Global Company 5- Contract is signed and the Registration and Pre-MKT activities are started PD PA PC PE PF PB PG PH PJ PI Argentina Mexico UM Br Chile Colombia Brazil Mexico Argentina Colombia Chile US$ 20.5 billion US$ 19.2 billion US$ 4.2 billion US$ 2.1 billion US$ 1.6 billion Our connections in Mercosur govts., and rest of Latin America (for swine flu & seasonal vaccines). AmbianceVentures USA

178. LATIN AMERICA Strong Market Leadership in Brazil, Argentina, Mexico (75% population of Latin America) Market Development: Stage 1: Brazil, Mexico, Argentina Stage 2: Colombia, Chile, Bolivia, Venezuela, Central America Stage 3: Other LatAm countries AmbianceVentures USA

180. Cardiovascular

181. Anaphylaxis and Emergency Care

182. Plasma-derived Therapeutics

183. AntiVenomsAmbianceVentures USA

185. Russia, Other CIS countries, Central Eastern Europe

186. Eurasia & PacRim

187. Middle East

188. AfricaAmbianceVentures USA

189. GLOBAL MARKETING, TRADE & BUSINESS STRATEGY We market in the following countries: North America: United States, Canada, Mexico European Union: United Kingdom, Germany, Italy, Russia, Bulgaria, Hungary, Portugal, Spain, Ireland Latin America / Central America: Argentina, Brazil, Chile, Bolivia, Peru, Panama, Caribbean Is., Guyana, Surinam, Colombia Asia, West Asia & Pacific: Afghanistan, Bangladesh, Bhutan, Cambodia, China, Indonesia, Iran, Iraq, Jordan, Middle East Nations, Malaysia, Philippines, Sri Lanka, Taiwan, Turkey, Vietnam Africa: Cameroons, Congo, Egypt, Ghana, Kenya, Libya, Mauritius, Morocco, Sudan, South Africa, Uganda, Zambia CIS Countries: Ukraine, Russia, Kazakhstan, Uzbekistan, Armenia, Tajikistan AmbianceVentures USA

190. Contact: Jay Nadkarni Ambiance Ventures, USA P.O. Box 622, Swiftwater, Pennsylvania 18370 (USA) Tel: 570/ 460-1804 Jay@AmbianceVentures.com; www.AmbianceVentures.com Contact: Valerian Lobo LOB International, India G-6 Khira Industrial Estates, B.M. Bhargava Rd. Santa Cruz (W), Mumbai 400 054 (INDIA) Tel: 9122- 2661-5006, 9122-2661-6008 Val@Lobin.com; www.lobin.com AmbianceVentures USA

191. THANK YOU Questions? Contact: JAY NADKARNI Cell: (570) 460-1804 Jay@AmbianceVentures.com AmbianceVentures USA