Fox Trial Finder was created by the Michael J. Fox Foundation to help increase the flow of willing participants — both people with Parkinson’s and control participants who do not have Parkinson’s — into the clinical trials that need them, accelerating the Parkinson’s drug development process. Clinical trials are a final and crucial step on the path to developing better treatments for Parkinson’s patients today. Around the world, between 40% and 70% of trials face delays because of a lack of volunteers. Fox Trial Finder will not only list ongoing PD clinical trials and research studies, but will match registrants to the trials that need them and are best-suited to their specific traits. Fox Trial Finder also has a secure and anonymous messaging system , making it much easier to find and act on suitable opportunities to get involved.

1. Fox Trial
Finder
TWO Year
Performance
Report
(U.S. DATA)
July 2011 – July 2013

2. Fox Trial Finder
Registered Volunteers
20,598 10,096
total
registered
volunteers
23% 77%
are
control
volunteers
29%
71%
are male
are female
median age
48
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
61%
39%
are in the
United States
have PD
are male
are female
median age
64
2

3. Fox Trial Finder
Registered Volunteers
Volunteers who have pd
Diagnosis
59 3.6
median
age of
diagnosis
median
years since
diagnosis
PD PROGRESSION
PD Symptoms
55% of PD Volunteers report experiencing
symptoms on one side of the body; 32%
on both sides.
Slowness, resting tremor, and sleep
disturbances are the most commonly
reported symptoms.
70%
57%
56%
48%
50%
symptoms on
both sides
n=6,413
55%
disabled but able
to walk unassisted
wheelchair/
bedridden
48%
44%
40%
30%
20%
10%
0%
Resting Tremor
symptoms on
one side
slowness
7%
32%
60%
Shuffled Gait
no
symptoms
small Handwriting
3%
Sleep disturbances
3%
n=12,729
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
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4. Fox Trial Finder
Registered Volunteers
Volunteers who have pd
Medication
29% 4.95
5% 1%
are not
medicated
mean
years on
medication
have had
Deep Brain
Stimulation
have had
another
neurosurgery
Medication use by type
45% of PD Volunteers currently taking medication take Sinemet.
45%
sinemet
20%
azilect
15%
pramipexole
14%
ropinirole
10%
0%
10%
symmetrel
20%
30%
40%
50%
n=8,401
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
4

5. Fox Trial Finder
Registered Volunteers
family history of pd
482/482
355/182
679/925
16/26
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
mother
PD Patients
Controls
sibling
father
child
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6. Clinical trials on
fox trial finder
200
548
trials
recruiting in
the US across...
...trial teams
in the US
44.0%
54.0%
24.7%
of trials are
connected to
a trial team
of trials are
interventional
of trials
are recruiting
controls
interventional/
observational
% of trials by
study focus
54% of trials are interventional,
46% are observational
60%
51%
Depression/
Anxiety
5%
Cognitive
Deficits
12%
50%
12.5%
Postural
Instability
(11%)
40%
observational
18%
Motor Symptoms
(not mutually exclusive)
Tremors
(12%)
phase 1
30%
n=200
15%
46%
phase 2
Gait
(13%)
20%
phase 3
17%
phase 4
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
10%
0%
BRADYKINESIA
(14%)
6

7. Clinical Trials on
Fox Trial Finder
30 Top Recruitment
Areas and Corresponding
Volunteer Footprint
No. of
volunteers
with PD
No. of trials
recruiting
New York - Northern New Jersey, NY/NJ
Chicago Norther Suburbs, IL/WI
Los Angeles - Western Suburbs, CA
Boston Suburbs, MA
Washington, NE Suburbs, DC/MD
Portland - Vancouver - Hillsboro, OR/WA
Philadelphia Western Suburbs, PA
Denver - Aurora - Broomfield, CO
Birmingham - Hoover, AL
Tampa - St.Petersburg - Clearwater, FL
New York - Long Island, NY
Seattle Southern Suburbs, WA
Houston - Sugar Land - Baytown, TX
San Jose - Sunnyvale - Santa Clara, CA
Baltimore - Towson, MD
Cleveland - Elyria - Mentor, OH
Atlanta - Sandy Springs - Marietta, GA
Palm Beach, FL
St. Louis, MO/IL
Phoenix - Mesa - Glendale, AZ
Richmond, VA
Minneapolis - St. Paul - Bloomington, MN/WI
639/20
393/20
227/20
315/19
100/18
137/17
306/15
231/12
102/12
325/11
95/11
241/10
190/10
166/10
113/10
198/9
182/9
174/9
128/9
251/8
236/8
201/8
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
Nashville - Davidson - Murfreesboro - Franklin, TN
Cincinnati - Middletown, OH/KY/IN
San Diego - Carlsbad - San Marcos, CA
Ann Arbor, MI
Oxnard - Thousand Oaks - Ventura, CA
New Haven - Milford, CT
Gainesville, FL
Detroit NE Suburbs, MI
San Francisco Peninsula Suburbs, CA
Los Angeles SE Suburbs, CA
Augusta - Richmond County, GA/SC
Bradenton, FL
Fairfax County, VA
Dallas North Suburbs, TX
San Francisco Eastern Suburbs, CA
Northern Jersey Suburbs, NJ
Riverside - San Bernardino - Ontario, CA
Austin-Round Rock - San Marcos, TX
Sacramento - Arden - Arcade-Roseville, CA
Hartford - West Hartford - East Hartford, CT
Orlando - Kissimmee - Sanford, FL
New York North Eastern Suburbs, NJ
74/8
8
160/7
148/7
7
206/6
28/6
6
265/5
219/5
5
5
176
150
140
122
114
110
108
85
85
84
7

8. web traffic and referrals
to fox trial finder
How do registrants learn
about fox trial finder?
55% 16%
11% 7%
MJFF event,
e-comm.
website, or
newsletter
from a friend,
family member or
support group
from TV or
print media
from a
healthcare
provider
2%
from another
PD organization
once online, how do people get to FTF?
How are web visitors finding us?
39.09%
search
common search terms
fox trial finder (1086), parkinson’s disease (456),
parkinson’s research (44), therapy for parkinson’s (44),
parkinson’s clinical trial (41), parkinson’s trials (35)
31.36%
25.74%
3.81%
The Michael J. Fox Foundation | Fox Trial Finder Performance Report
referrals
direct
top referral sites
1. pdtrials.org
2. facebook.com
3. michaeljfox.org
ad campaigns
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