This document discusses fostering digital industrial innovation in Europe through cloud-based high-performance computing (HPC) simulation in advanced manufacturing. It highlights mega trends in computing power and challenges and opportunities for industries like automotive and aeronautics. Case studies are presented on using virtual prototyping and crash simulation through HPC cloud resources to enable concurrent engineering across global supply chains. The document concludes that simulation is a transformative technology that can boost industry competitiveness and attractiveness if supported through public-private partnerships and ecosystem development.