SAC 25 Final National, Regional & Local Angel Group Investing Insights 2024 0...
FLOW CHEM.pptx
1. Synthesis of API / intermediates using Flow
chemistry in a safe & efficient way
Angew. Chem. Int. Ed. 2015, 54, 6688 – 6728
2. Synthesis of API / intermediates using Flow
chemistry in a safe & efficient way
*PIVOTAL : IMP or CRITICAL PARAMETER
3. Synthesis of API intermediates using Flow chemistry in a safe & efficient way
4. Synthesis of API intermediates using Flow chemistry in a safe & efficient way
5. Synthesis of API intermediates using Flow chemistry in a safe & efficient way
6. Synthesis of API intermediates using Flow chemistry in a safe & efficient way
residence time = reactor volume / flow rate
7. Development of In-line Flash Chromatography Purification
J. Org. Chem. 2021, 86, 20, 14079–14094
8. Org. Process Res. Dev. 2013, 17, 9, 1192–1208
A new enabling technology for the pumping of organometallic reagents
9. Malaria is a serious global health issue. Artemisinin
combination treatments are the first-line drugs, but supplies are
limited because artemisinin is obtained solely by extraction
from Artemisia annua
Angewandte Chemie Vol5 1, Issue 7 p. 1706-1709
10. References
1) Microreactors in Organic Synthesis and Catalysis, 2nd ed.; Wiley-VCH: Weinheim, 2013.
2) Hartman, R. L.; McMullen, J. P.; Jensen, K. F. Angew. Chem., Int. Ed. 2011, 50, 7502
3) Wiles, C.; Watts, P. Chem. Commun. 2011, 47, 6512
4) Malet-Sanz, L.; Susanne, F. J. Med. Chem. 2012, 55, 4062
5) Rodrigues, T.; Schneider, P.; Schneider, G. Angew. Chem., Int. Ed. 2014, 53, 5750
6) Elvira, K. S.; Solvas, X. C.; Wootton, R. C. R.; deMello, A. J. Nat. Chem. 2013, 5, 905
7) Wu, H.; Khan, M. A.; Hussain, A. S. Chem. Eng. Commun. 2007, 194, 760
8) Anderson, N. G. Org. Process Res. Dev. 2012, 16, 852
9) Gutmann, B.; Cantillo, D.; Kappe, C. O. Angew. Chem., Int. Ed. 2015, 54, 6688
10) Pinho, V. D.; Gutmann, B.; Kappe, C. O. RSC Adv. 2014, 4, 37419
11) Sterk, D.; Jukic, M.; Casar, Z. Org. Process Res. Dev. 2013, 17, 145
12) Snead, D. R.; Jamison, T. F. Chem. Sci. 2013, 4, 2822
13) Hartwig, J.; Ceylan, S.; Kupracz, L.; Coutable, L.; Kirschning, A. Angew. Chem., Int.
Ed. 2013, 52, 9813
14) Zhang, P.; Russell, M. G.; Jamison, T. F. Org. Process Res. Dev. 2014, 18, 1567
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Synthesis of API intermediates using Flow chemistry in a safe & efficient way
