This document summarizes a panel discussion on the impact of regulations on the over-the-counter (OTC) derivatives market. The panelists represented different parts of the OTC transaction value chain, from trade execution to reporting and clearing. Key points discussed included the uncertainty created by various US and European regulations; differences between the Dodd-Frank Act and European regulations; challenges around defining what can and cannot be cleared; and how regulations may change trade execution and post-trade processing. The panelists expected significant changes to systems, business models, and the relationship between buy-side and sell-side firms as a result of new OTC derivatives regulations.