Faster, Better, Safer—Getting CML Treatment Right: How to Enhance Outcomes With Precision Medicine in the TKI Era
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Jorge E. Cortes, MD discusses leukemia in this CME activity titled Faster, Better, Safer—Getting CML Treatment Right: How to Enhance Outcomes With Precision Medicine in the TKI Era. For the full presentation, downloadable practice aids, transcript, complete CME information, and to apply for credit please visit us at http://bit.ly/2gXAedd. CME credit will be available until December 12, 2017.
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Chair and Presenter, Manish A. Shah, MD, FASCO, Ronan J. Kelly, MD, MBA, FASCO, and Prof. Dr. Markus Moehler, discuss gastric cancer in this CME/MOC/NCPD/AAPA activity titled “Catalysts for Change in Gastric & GEJ Cancer: Digesting New Evidence & Future Directions of Care With Innovative Immunotherapy & Targeted Platforms.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA information, and to apply for credit, please visit us at https://bit.ly/3VHpl55. CME/MOC/NCPD/AAPA credit will be available until July 2, 2025.Unlocking the Power of Modern Therapeutic Regimens for Prostate Cancer: Exper...
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Chair and Presenters, Karim Fizazi, MD, PhD, Pedro C. Barata, MD, MSc, FACP, Kim N. Chi, MD, FRCPC, and Alicia K. Morgans, MD, MPH, discuss prostate cancer in this CME/MOC/NCPD/AAPA/IPCE activity titled “Unlocking the Power of Modern Therapeutic Regimens for Prostate Cancer: Experts Put the Pressure on Key Evidence and Real-World Strategies to Optimize Patient Care.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/3VqHUKU. CME/MOC/NCPD/AAPA/IPCE credit will be available until July 1, 2025.Precision Tactics in HER2-Positive GI Malignancies: Capitalizing on HER2-Targ...
Precision Tactics in HER2-Positive GI Malignancies: Capitalizing on HER2-Targ...PVI, PeerView Institute for Medical Education
Chair and Presenters, Yelena Y. Janjigian*, MD, Shubham Pant, MD, and John Strickler, MD, discuss HER2+ GI malignancies in this CME/MOC/NCPD/AAPA/IPCE activity titled “Precision Tactics in HER2-Positive GI Malignancies: Capitalizing on HER2-Targeted Regimens to Improve Outcomes for Gastric/GEJ Cancers, CRC, and BTC.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/AAPA/IPCE information, and to apply for credit, please visit us at https://bit.ly/49K4Qcb. CME/MOC/NCPD/AAPA/IPCE credit will be available until June 30, 2025.Anticoagulation Therapy in NVAF: A Quality Improvement Initiative
Anticoagulation Therapy in NVAF: A Quality Improvement InitiativePVI, PeerView Institute for Medical Education
Chair Kun "Kevin" Xiang, MD, PhD, discusses atrial fibrillation in this CME/MOC/NCPD/CPE activity titled “Anticoagulation Therapy in NVAF: A Quality Improvement Initiative.” For the full presentation, downloadable Practice Aids, monograph, and complete CME/MOC/NCPD/CPE information, and to apply for credit, please visit us at https://bit.ly/2UoPplb. CME/MOC/NCPD/CPE credit will be available until June 12, 2025.Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communica...
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Milan J. Anadkat, MD, and Dale V. Reisner discuss generalized pustular psoriasis in this CME activity titled "Supporting Patient-Centered Care in Generalized Pustular Psoriasis: Communications Strategies to Improve Shared Decision-Making." For the full presentation, please visit us at www.peervoice.com/HUM870.Improving Outcomes for Pediatric Patients With Uncontrolled Moderate-to-Sever...
Improving Outcomes for Pediatric Patients With Uncontrolled Moderate-to-Sever...PVI, PeerView Institute for Medical Education
Chair, William Anderson, MD, discusses severe asthma in this CME/MOC/NCPD/CPE/AAPA activity titled “Improving Outcomes for Pediatric Patients With Uncontrolled Moderate-to-Severe Asthma Using a Collaborative Approach: Recognition, Referral, and Management in the Era of Targeted Treatment Options.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/3IJWFAR. CME/MOC/NCPD/CPE/AAPA credit will be available until June 13, 2025.Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Prac...
Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Prac...PVI, PeerView Institute for Medical Education
Chair and Presenters Professor Stephen Johnston, MA, PhD, Patrick Neven, MD, PhD, and Joyce O’Shaughnessy, MD, prepared useful Practice Aids pertaining to breast cancer for this CME/MOC/CPD/NCPD/CPE/AAPA activity titled “Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Practical Roadmap for CDK4/6 Inhibition in the Adjuvant Setting.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPD/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49HZ5fH. CME/MOC/CPD/NCPD/CPE/AAPA credit will be available until June 21, 2025.Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Prac...
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Chair and Presenters Professor Stephen Johnston, MA, PhD, Patrick Neven, MD, PhD, and Joyce O’Shaughnessy, MD, discuss breast cancer in this CME/MOC/CPD/NCPD/CPE/AAPA activity titled “Safeguarding Patients With HR+, HER2-, High-Risk, Early Breast Cancer: A Practical Roadmap for CDK4/6 Inhibition in the Adjuvant Setting.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CPD/NCPD/CPE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49HZ5fH. CME/MOC/CPD/NCPD/CPE/AAPA credit will be available until June 21, 2025.Cases in the Community: Optimizing Treatment and Considering Weight Managemen...
Cases in the Community: Optimizing Treatment and Considering Weight Managemen...PVI, PeerView Institute for Medical Education
Chair, Javier Morales, MD, FACP, FACE, discusses Type 2 diabetes in this CME/CE/AAPA activity titled “Cases in the Community: Optimizing Treatment and Considering Weight Management as a Primary Goal in People with T2DM.” For the full presentation, downloadable Practice Aids, and complete CME/CE/AAPA information, and to apply for credit, please visit us at . CME/CE/AAPA credit will be available until June 11, 2025.Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standard...
Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standard...PVI, PeerView Institute for Medical Education
Chair, Nicole Lamanna, MD, discusses chronic lymphocytic leukemia in this CME activity titled “Redefining Frontlines in CLL: Key Questions on the Role of CIT, BTKi Standards, and Innovative BTKi Combinations.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/49Mazi3. CME credit will be available until June 11, 2025.Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...PVI, PeerView Institute for Medical Education
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, discuss Alzheimer’s disease in this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...
Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neu...PVI, PeerView Institute for Medical Education
Co-Chairs, Val J. Lowe, MD, and Cyrus A. Raji, MD, PhD, prepared useful Practice Aids pertaining to Alzheimer’s disease for this CME/AAPA activity titled “Alzheimer’s Disease Case Conference: Gearing Up for the Expanding Role of Neuroradiology in Diagnosis and Treatment.” For the full presentation, downloadable Practice Aids, and complete CME/AAPA information, and to apply for credit, please visit us at https://bit.ly/3PvVY25. CME/AAPA credit will be available until June 28, 2025.Adapting HIV Treatment for People With Substance Use Disorder
Adapting HIV Treatment for People With Substance Use DisorderPVI, PeerView Institute for Medical Education
Chair, Monica Gandhi, MD, MPH, prepared useful Practice Aids pertaining to HIV for this CME/MOC/CE/AAPA activity titled “Adapting HIV Treatment for People With Substance Use Disorder.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49hgPxT. CME/MOC/CE/AAPA credit will be available until June 4, 2025.Adapting HIV Treatment for People With Substance Use Disorder
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Chair, Monica Gandhi, MD, MPH, discusses HIV in this CME/MOC/CE/AAPA activity titled “Adapting HIV Treatment for People With Substance Use Disorder.” For the full presentation, downloadable Practice Aids, and complete CME/MOC/CE/AAPA information, and to apply for credit, please visit us at https://bit.ly/49hgPxT. CME/MOC/CE/AAPA credit will be available until June 4, 2025.Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evo...
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Chair, Carla M. Nester, MD, MSA, FASN, discusses glomerular kidney disease in this CME activity titled “Aligning Clinical Practice With Emerging Evidence: Navigating the Rapidly Evolving Landscape of Glomerular Kidney Disease Management.” For the full presentation, downloadable Practice Aids, and complete CME information, and to apply for credit, please visit us at https://bit.ly/3wJPTs1. CME credit will be available until June 4, 2025.More from PVI, PeerView Institute for Medical Education (20)
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Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
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Pictorial and detailed description of patellar instability with sign and symptoms and how to diagnose , what investigations you should go with and how to approach with treatment options . I have presented this slide in my 2nd year junior residency in orthopedics at LLRM medical college Meerut and got good reviews for it
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Breast cancer: Post menopausal endocrine therapy
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
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Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
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Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
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Protection of transgene or genetic cargo from degradative action of systemic and endonucleases,
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