The document is a scanned copy of a contract for the sale of a residential property located in California. The contract details the purchase price of $1,100,000, specifies a closing date of January 15, 2023, and lists standard contingencies for the buyer's inspection of the property and ability to obtain financing. The contract is signed by both the buyer and seller agreeing to the terms of the sale.
شرح عن طقس المصبتا (الصباعة) عند الصابئة المندائيين الترميذا علاء النشمي
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
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Mandaean holy book Ginza Rba - Mandaic
كتاب الصابئة المندائيون المقدس مصحف جنزا ربا المبارك - باللغة المندائية
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
www.MandaeanNetwork.com
Mandaic dictionary القاموس المندائي
تاليف الترميذا خلف عبد ربه ، خالد كامل عودة
تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
مكتبة كتب الصابئة المندائيين
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شرح عن طقس المصبتا (الصباعة) عند الصابئة المندائيين الترميذا علاء النشمي
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
Download from: www.MandaeanNetwork.com
Mandaean holy book Ginza Rba - Mandaic
كتاب الصابئة المندائيون المقدس مصحف جنزا ربا المبارك - باللغة المندائية
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
www.MandaeanNetwork.com
Mandaic dictionary القاموس المندائي
تاليف الترميذا خلف عبد ربه ، خالد كامل عودة
تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
مكتبة كتب الصابئة المندائيين
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Kerala Land Relinquishment Act - Panchayath has no power to include a revenue puramboke in their asset register without proper order by RDO- High court order 2020
الموجز في تاريخ الصابئة المندائيين - العرب البائدة تأليف عبد الفتاح الزهيري
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
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الدرفش (دربشا) راية الصابئة المندائيين ورمزهم الديني امين فعيل حطاب
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
Download from: www.MandaeanNetwork.com
قواعد اللغة المندائية تأليف أمين فعيل حطاب ، اللغة المندائية هي لغة الصابئة المندائيين
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
www.MandaeanNetwork.com
Design of Diesel Engine by Prof. Sagar DhotareSagar Dhotare
Design of Diesel Engine covers following component design:-
Design of Piston
Design of Cylinder and stud
Design of Cylinder head and wet Liner
Design of Piston Ring and Piston Pin
Design of Connecting Rod with I cross-section
Design Both eye, CAP and CAP bolts
سيدنا النبي إبراهيم الخليل عليه السلام ابو الانبياء تأليف عباس محمود العقاد
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
Download from: www.MandaeanNetwork.com
Kerala Land Relinquishment Act - Panchayath has no power to include a revenue puramboke in their asset register without proper order by RDO- High court order 2020
الموجز في تاريخ الصابئة المندائيين - العرب البائدة تأليف عبد الفتاح الزهيري
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
Download from: www.MandaeanNetwork.com
الدرفش (دربشا) راية الصابئة المندائيين ورمزهم الديني امين فعيل حطاب
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
Download from: www.MandaeanNetwork.com
قواعد اللغة المندائية تأليف أمين فعيل حطاب ، اللغة المندائية هي لغة الصابئة المندائيين
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
www.MandaeanNetwork.com
Design of Diesel Engine by Prof. Sagar DhotareSagar Dhotare
Design of Diesel Engine covers following component design:-
Design of Piston
Design of Cylinder and stud
Design of Cylinder head and wet Liner
Design of Piston Ring and Piston Pin
Design of Connecting Rod with I cross-section
Design Both eye, CAP and CAP bolts
سيدنا النبي إبراهيم الخليل عليه السلام ابو الانبياء تأليف عباس محمود العقاد
تم تحميل هذا الكتاب من موقع مكتبة موسوعة العيون المعرفية
Download from: www.MandaeanNetwork.com
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
