Dyshidrotic eczema is a chronic skin condition characterized by burning, itching, and a blistering rash, predominantly affecting adults in their 20s to 40s, particularly on the palms and soles of the feet. The condition involves irritation of the skin's epidermis due to immune system inflammatory cells, with atopic dermatitis being another related term. The exact cause of dyshidrotic eczema remains unclear, and limited research exists regarding the immune response specific to this condition.