Drug informatics group assignment

1. Dep: C/Pharmacy
4th Year Degree Program
Group Assignment Of DI
Group II
CAMPUS

2. Name ID
1. Abdi Isak 0153
2. Ukash Mustefa 0110
3. Mohammed Jemal 0131

3. CLONIDINE
Overview
Clonidine category
Clonidine Mechanism of action
Clonidine Pharmacokinetics
Clonidine Medical use
Side effects
Drug drug interactions
Drug food interactions

4. CLONIDINE
Clonidine:Category alpha 2 adrenergic receptor
The treatment of hypertension
Brand name _Catapres

5. Alpha 2-RECEPTOR
The Apha2 Adrenergic Receptor is an inhibitory
G-protein coupled receptor that binds
norepinephrine and is present in both CNS and
sympathetic arm of the ANS.

6. Cont's
• with in sympathetic fibers ,alpha2 receptor are
uniquely found on the pre synaptic terminal of
postganglionic.

8. Mechanism Of Action
• Clonidine treats high blood pressure by
stimulating alpha2 receptor in the brain ,thus
inhibiting the release of norepinephrine ,and
then decreases peripheral vascular resistance,

9. Cont's
will become vasodilation and the pressure will
decrease.
It has specificity toward presynaptic alpha2
receptor in the vasomotor center in the
brainstem.

11. Pharmacokinetics
• Bioavailability:immediate release(75-85%)
• Protein bound:20-40%
• Duration:6-10hr
• Metabolism in liver
• Elimination half life:12-16hr
• Excretion in urine

12. Medical Uses
1. Hypertention
2. Severe dysmenorrhea
3. Vascular migraine headache
4. Treatment of alcohol withdrawal used in
conjunction with benzodiazepines
5. Attention-deficit hyperactivity disorder(ADHD)
6. Restless leg syndrome
7. Tourettes syndrome

13. Dosage Form
1.Oral Tablet
0.1mg
0.2mg
0.3mg
2 times a day(morning and bedtime) to
0.1mg

14. 2.Injectable solution

15. 3.Transdermal patch
0.1mg/day
0.2mg/day
0.3mg/day
Change every 7 days

16. Side effect
Very common side effects
• Dizziness
• Skin reactions(if given transdermally)
• Orthostatic
• Somnolence dose dependent

17. Cont's
Common side effects
• Constipation
• Vomiting
• Rash
• Weight gain/loss

18. Cont's
Rare side effects
• Hallucination
• Pruritus
• Nasal dryness
• alopecia

19. Clonidine and Pregnancy
Pregnancy category C
Clonidine may be pass through the barrier of
placenta then enter blood circulation of fetus and
cause decrease blood pressure of the fetus with
decrease heart rate.Clonidine can pass into
breast milk and may harm the baby;
contraindicated in pregnant women

20. Drug-drug Interaction
Asprin
Using asprin

21. Drug-Food Interactions
Ginseng:may affect the action of the clonidine
and can increase the boold pressure.

22. THE END