Pathology of Ovary mainly neoplasms; germ cells and others

3. ovarian lesions
teratomas

4. Clinical Features

5. Germ cell tumor and their marker
substances
NEOPLASM AFP hCG
DYSGERMINOMA _ +/_
ENDODERMAL SINUS (Y S)TUMOR + _
IMMATURE TERATOMA _ _
MIXED GERM CELL TUMOR +/_ +/_
CHORIOCARCINOMA _ +
EMBRYONAL CARCINOMA + +

6. Teratoma

7. Mature (benign) Teratomas

8. terms..a/w..teratoma
• Dermoid cyst • Gliomatosis peritonei

10. Gross features

11. Microscopical features..all three germ

14. Malignant change in cystic teratoma

16. Immature (malignant) teratoma

17. Gross

19. Grading
• Norris grading system
• 1
• 2
• 3

20. Monodermal teratomas

21. Struma ovarii

23. • Micro:

24. Carcinoid tumors

25. Dysgerminoma

26. Dysgerminoma

27. Dysgerminoma a/w …

32. Endodermal sinus tumor

33. Endodermal sinus tumor

34. Endodermal sinus tumor

35. Endodermal sinus tumor….hyaline
globule

36. Embryonal carcinoma

37. • Median diameter
17cm
• External surface:
• smooth and
glistening
• Cut surface:
predominantly
solid and
variegated
Extensive areas of
necrosis and
hemorrhage

39. Polyembryoma

42. Choriocarcinoma

44. Histopathology

46. Metastases IHC