CTS is a leading Israeli pharmaceutical company operating since 1921 that develops, manufactures, and markets oral care products. As the local representative for Geistlich, an established Swiss dental company, CTS has vast knowledge of consumer behavior and oral health needs in local and international markets. CTS offers several lines of specialty toothpastes, including for orthodontic patients, pregnant women, and reducing dentin hypersensitivity. Their orthodontic toothpaste contains active ingredients like xylitol, vitamins, and zinc that help maintain oral hygiene and prevent issues like white spot lesions and ulcers during orthodontic treatment.

1. CTS
Your Partner
in Oral-Care

2. Who We Are?
• A leading Israeli pharmaceutical company operating
since 1921
• Develops, manufactures and market oral-care
products
• International experience - business associations
with some of the major world companies, amongst
them: Geistlich, UCB, Takeda, HRA Pharma and
others.

3. CTS
Your Partner in Oral Care
Why Us?
Experts in the dental field
as local representative for more
than 15 years of Geistlich (an
established Swiss company of 150
years).
Vast knowledge in consumer
behavior and needs
as a marketer and distributer of oral care
products in local & international markets

4. Why Us? Our Products
Our line of children’s toothpastes

5. Why Us? Our Products
Our line of specialty toothpastes

6. Our line of specialty toothpastes
Orthodontic Patients Pregnant women and after
Childbirth
Oral health and reduced
dentin hypersensitivity

7. A Specialized Toothpaste
for Orthodontic Patients

8. According to the Dental Health Component &
Dental Aesthetic Index, more than 80% of the
population need orthodontic treatment (1)
Adolescents aged 10-17 Adults

9. Fixed Appliances Used for Orthodonic Treatment
Cause Difficulty in Maintaining Oral Hygiene
Resulting in Several Common Problems:
White-spot lesions Ulcers, Gingivitis
and Halitosis
Accumulation of
oral biofilm
(bacterial plaque)
Demineralization
of tooth enamel

10. Specialized Active Ingredients
for Optimized Oral Hygiene During Orthodontic Treatment
Xylitol reduced the percentage of
children with new caries lesions
at 1 year compared with placebo
(5)
Mean ulcer index were
significantly lower with vitamin
E compared to control group
(7)
Mouth rinse containing zinc
has a significant antibacterial
and plaque control effect (8)
Palm vitamin E
Xylitol Zinc Chloride Vitamin E

11. Ortho-Dent Aid
Specialized Tooth Paste
Provides the necessary active ingredients to maintain oral hygiene and health
Xylitol
Vitamin
B5
Vitamin
E
Xylitol - a natural carbohydrate. Researches have shown that xylitol
reduces the acidity levels derived from a bacterium "mutants" in
saliva, thus contributing to the reduction of dental caries
Vitamin B5 – Water soluble vitamin that has an accelerating effect
on wound healing in damaged epithelium in oral mucosa
Vitamin E - a fat-soluble vitamin that prevents oxidation and
damage to cells by reaction with damaging free radicals. Many
studies indicate vitamin E has curative effect in treatment and
prevention of gingivitis
Zinc ( Zn+2) has an ability to limit bacterial growth and plaque
formation . Zinc that is retained in oral cavity 2-3 hours after tooth
brushing inhibits the production of volatile sulphur-containing
compounds (VSC) contributing to reduction in Halitosis
Zinc
Chloride

12. Ortho-Dent Aid
Specialized Tooth Paste
keeps mouth clean and healthy during orthodontic treatment
Protects the mouth, teeth, gums and oral mucus and inhibits the
formation of oral biofilm.
Prevents enamel demineralizing and dental caries.
Iinnovative texture That allows it to easily access spaces between
orthodontic braces.
Mild fruit mint flavor for maximum compliance

13. References
1. Cardoso, Chrystiane F., et al. "The dental aesthetic index and dental health component of the index of orthodontic
treatment need as tools in epidemiological studies." International journal of environmental research and public health 8.8
(2011): 3277-3286.
2. Lucchese, Alessandra, and Enrico Gherlone. "Prevalence of white-spot lesions before and during orthodontic treatment
with fixed appliances." The European Journal of Orthodontics 35.5 (2013): 664-668.
3. Zurfluh, M. A., H. J. van Waes, and A. Filippi. "The influence of fixed orthodontic appliances on halitosis." Schweizer
Monatsschrift fur Zahnmedizin= Revue mensuelle suisse d'odonto-stomatologie= Rivista mensile svizzera di odontologia e
stomatologia/SSO 123.12 (2012): 1064-1069.
4. Tanner, A. C. R., et al. "White-spot lesions and gingivitis microbiotas in orthodontic patients." Journal of dental
research (2012): 0022034512455031.
5. Zhan, L., et al. "Effects of xylitol wipes on cariogenic bacteria and caries in young children." Journal of dental research 91.7
suppl (2012): S85-S90.
6. Nyøygard L, Nyquist Borgeraas I, Herlofson BB. Hand-out from the presentation: Oral mucosal effects of toothpastes
containing papain and vitamin B5 at 5th Biennial Congress European Association of Oral Medicine, Gøteborg, Sweden, 24th-
26th August 2000
7. Jaarin, Kamsiah, et al. "Comparative effect of palm vitamin E and ranitidine on the healing of ethanol-induced gastric lesions
in rats." International journal of experimental pathology 80.5 (1999): 259.
8. Gu, Haijing, et al. "Effect of ZnCl 2 on plaque growth and biofilm vitality."Archives of oral biology 57.4 (2012): 369-375..
9. Embery G, Rølla G. Clinical and biological aspects of dentifrices, Oxford University Press, Oxford, 1992.
10. Giertsen E, Scheie AA, Rølla G. Plaque inhibitition by a combination of zinc citrate and sodium lauryl sulphate. Caries Res
1989;23:278-283
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14. Specialized Toothpaste
for Pregnant women and after Childbirth

15. Periodontal disease & Pregnancy (1,2)
Periodontal disease is one of the most common
chronic disorders of infectious origin known in
humans, with a reported prevalence varying
between 10 and 60% in adults, depending on
diagnostic criteria
Hormonal changes during pregnancy
mainly increased Estrogen and
progesterone levels exaggerated
inflammatory response of gingiva

16. Periodontal Disease is Associated with Adverse
Pregnancy Outcomes (1)
preterm
birth
low birth
weight
shortened gestational age
& miscarriage

17. oral prophylaxis and periodontal treatment can
lead to a 57% reduction in preterm low birth
weight and a 50% reduction in preterm births(1)

18. Parabens
free
Saccharin
free
SLS free
vitamin E
TCP
Vitamin E: Vitamin E is an anti-oxidant. Recent studies have indicated that
vitamin E may have therapeutic effects in treating and preventing periodontal
pathology (3)
Tri-Calcium Phosphate (TCP): Since the structure of TCP is similar to
hydroxyapatite, once the functionalized calcium ions are released, they
readily interact with the tooth surface and subsurface and provides enhanced
re-mineralization and added protection against demineralization.
While other calcium phosphate additives may require an acidic pH, which
could limit the benefits to the tooth, functionalized TCP can offer optimal
benefits when delivered in a neutral pH environment.
Dent-Aid
specialized formulation for pregnant women

19. References
1. Xiong, X., et al. "Periodontal disease and adverse pregnancy outcomes: a systematic
review." BJOG: An International Journal of Obstetrics & Gynaecology 113.2 (2006): 135-143.
2. Bowsher, J. "Oral care during pregnancy." Professional care of mother and child 7.4 (1996):
101-102.
3. Bhuvaneswari, P. "Antioxidants in Oral Healthcare."
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20. Specialized toothpaste enriched with natural
Dead Sea Minerals
For oral health and reduced dentin
hypersensitivity

21. Dentin Hypersensitivity (DH)
• Painful clinical condition with an
incidence ranging from 4 to 57% (6)
• The prevalence of DH is between 60
and 98 percent in patients with
periodontitis (6)
• Higher incidence of DH is reported in
females than in males (6)
• Most affected patients are in the age
group of 20–50 years, with a peak
between 30 and 40 years of age (6)

22. Treatment (6)
Oral hygiene
Use of appropriate
toothbrush and correct
method of tooth
brushing
Use of Desensitizing
toothpastes

23. Minerals Contribute to Oral Hygiene and Reduced
Hypersensitivity
Desensitization
Anti-bacterial
Re-
mineralization
Potassium- reduced dentin hypersensitivity and improved overall
patient comfort (1,2)
Improve remineralization and increase fluoride uptake (4)
Sodium Bicarbonate– Increase pH of saliva thus prevent caries by
creating a hostile environment for the growth of aciduric bacteria
and by reducing enamel solubility and increase remineralization of
enamel (3)
Fluoride - effective in helping to protect the dental enamel from
demineralisation and enhance remineralisation (5)
Calcium - calcium salts or calcium containing materials added to oral
care products enhance the delivery and retention of fluoride into the oral
cavity and act as additional sources of calcium to promote enamel
remineralisation or reduce demineralisation processes (5)

24. Dent Aid Dead Sea
• Enriched with dead sea minerals
• Contains 10 active minerals that are known for their
therapeutic and health benefits.
• For reduced prevention of caries and accumulation
of tartar and dentin hypersensitivity
• Light pepermint and slightly salty taste.
For healthy teeth and gum and reduced dentin
hypersensitivity

25. References:
1. Barkvoll P, Fremtidens tannkrem, In: Hjørting.Hansen E (Ed). Odontologi 1994, Munksgaard, Copenhagen, 1994, pp.171-179.
2. Sowinski, J., et al. "Comparative investigations of the desensitising efficacy of a new dentifrice." Journal of Clinical Periodontology 28.11
(2001): 1032-1036.
3. Legier-Vargas K1, Mundorff-Shrestha SA, Featherstone JD, Gwinner LM Effects of sodium bicarbonate dentifrices on the levels of
cariogenic bacteria in human saliva. Caries Res. 1995;29(2):143-7.
4. Schemehorn BR1, Orban JC, Wood GD, Fischer GM, Winston AE. Remineralization by fluoride enhanced with calcium and
phosphate ingredients. J Clin Dent. 1999;10(1 Spec No):13-6.
5. Li, Xiaoke, et al. "The remineralisation of enamel: a review of the literature."Journal of dentistry 42 (2014): S12-S20.
6. Orchardson, Robin, and David G. Gillam. "Managing dentin hypersensitivity."The Journal of the American Dental Association 137.7
(2006): 990-998
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