This devotional discusses the opposition between natural desires and following God. It argues that true faith requires sacrificing one's independence and natural rights by crucifying selfish desires and submitting fully to God's will. Several passages note that moral excellence from a worldly view can actually oppose surrender to God, and that following Christ demands denying oneself and one's entire natural life through sacrifice. The cost of discipleship is giving up everything to follow Jesus' command to lose one's life. True spirituality comes only through consciously sacrificing one's natural instincts and independence.